The prescription, distribution and sale of human growth hormone for alleged anti-aging aesthetic and athletic enhancement have been on a rampant rise. This is despite of the fact that potential risks far outweigh insignificant benefit in normally aging individuals as per Dr. Thomas Perls, Director of the New England Centenarian Study and an associate professor of Medicine at Boston University School of Medicine.

It is worth noting here that the FDA issued an alert in January 2007 against illegal prescribing and distributing hGH for anti-aging and body building.

From Sciencedaily.com:

As stated on the Albany County District Attorney’s website, in the case of Operation Which Doctor, numerous governmental agencies are “working together to take down a nationwide distribution ring of anabolic steroids, Human Growth Hormones and other controlled substances, by targeting the ring’s dirty doctors, its distributors that pose as clinics, and ultimately the ring’s supplier Signature Pharmacy.”

Contrary to published claims, neither long-term safety nor health benefits have been demonstrated in normally aging individuals taking hGH. A review of clinical studies among healthy, normally aging individuals found that hGH supplementation does not significantly increase muscle strength or aerobic exercise capacity. However, documented adverse effects include soft tissue edema, arthralgias (joint pains), carpal tunnel-like syndrome, gynecomastia (enlarged breasts) and insulin resistance with an elevated risk of developing diabetes. Increasingly more and more animal and laboratory studies suggest an increased cancer risk.

It was suggested by the authors that several measures need to be implemented for addressing the inappropriate distribution and use of human growth hormone.

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The abuse of human growth hormone can lead to serious health complications, a fact that was highlighted by Dr. Alan Rogol, testifying before the U.S. House of Representatives Government Reform Committee on behalf of The Endocrine Society while outlining the legal medical use of human growth hormone (HGH) and possible complications regarding its abuse.

It is worthwhile to note that the off-label usage of human growth hormone (HGH) has been linked with severe health complications in the recent past. The same was affirmed by Dr. Alan Rogol who highlighted that abuse of HGH can lead to consequences such as muscle weakness and heart disease.

From News-Medical.Net:

“Magazines and the internet are replete with advertisements for substances marketed as ‘growth hormone’,” said Dr. Rogol. “Growth hormone, however, can only work if injected, and many of these preparations are taken orally, so they cannot possibly be HGH.”

These compounds falsely sold as HGH may contain other unlisted ingredients, including anabolic steroid hormones or steroid precursors, which have been found to promote the growth of tumors. These unlisted ingredients can also appear in unknown quantities, while the entire preparation is of unknown purity.

In addition, the vast majority of clinically administered growth hormone is made by recombinant DNA techniques and not from human tissue. “Growth hormone made from human tissue has largely been removed from the market because of the rare but fatal Creutzfeldt-Jakob disease,” said Dr. Rogol. “Some of the HGH now available clandestinely is of human origin and may carry this deadly biological agent.”

It was further remarked by Dr. Rogol that HGH use has to made only in strict accordance with qualified medical advice and not otherwise.

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Dr. Alan Rogol, while testifying before the U.S. House of Representatives Government Reform Committee on behalf of The Endocrine Society, outlined the legitimate medical use of human growth hormone.

It was remarked that severe health complications may happen when HGH is abused by any one and individuals including sportsmen and celebrities run a high risk of HGH abuse and health risks while attempting to stay young with growth hormone.

From News-Medical.Net:

“There are a number of safe and legitimate FDA-approved uses of growth hormone in adults and children,” said Dr. Rogol. “The off-label use of growth hormone, which primarily is in the anti-aging and body image or athletic market, comes with increased risks.”

One risk factor is that most off-label users are usually unaware of the correct doses. “One can assume that the dose administered would be much greater than that given for legitimate purposes,” said Dr. Rogol.

At higher HGH dosages, it is possible to achieve levels similar to those found in the endocrine disease acromegaly, which is caused by too much growth hormone in the body. This condition can lead to severe muscle weakness and even heart disease.

According to Dr. Rogol, perhaps the most insidious off-label use is by athletes and others who believe they are using actual growth hormone, when in fact they may be receiving an entirely different substance.

“Magazines and the internet are replete with advertisements for substances marketed as ‘growth hormone‘,” said Dr. Rogol. “Growth hormone, however, can only work if injected, and many of these preparations are taken orally, so they cannot possibly be HGH.”

It was further remarked by Dr. Rogol that human growth hormone, which is made from human tissue, has already been removed from the legal drug market due to probability of the rare yet fatal Creutzfeldt-Jakob disease.

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According to Roger Clemens’ lawyers, the player and his camp were not at all serious when they questioned McNamee’s mental state. That is why Clemens’ camp filed a motion in Brooklyn federal court to dismiss a defamation lawsuit by Brian McNamee.

According to a report last November 12, in the New York Daily News, Roger Clemens, his lawyer Rusty Hardin and others were not serious about their accusations against Brian McNamee. This is according to the motion written by Joe Roden filed in Brooklyn. Roden was lawyer and a member of Hardin’s firm.

Roden said it was just part of the public battle of words. They do not intend to suggest to readers that McNamee is actually mentally unfit.

He also added that they were just trying to refute false evidence. Their action could not be considered as defamation. Clemens’ camp was recalled to have denied that Clemens used steroids or HGH. According to them, Clemens’ former trainer was just manufacturing evidence.

McNamee said the seven-time Cy Young Award winner received steroid and HGH injections while he was still with the Blue Jays and the Yankees from 1998 to 2001.

He even showed evidence in court by providing bloody gauze pads and used syringes, which he turned over after a congressional hearing last year.

From The Associated Press:

NEW YORK — Lawyers for Roger Clemens filed a motion in Brooklyn federal court to dismiss a defamation lawsuit by the pitcher’s former trainer, claiming statements that accused Brian McNamee of trying to shake down Clemens were not serious.

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Former congressional representative Tom Davis says Roger Clemens was in denial during the steroids probe. Davis once headed the House committee that investigated on Mark McGwire and Roger Clemens that eventually led to the downfall of their careers.

Davis opines that if only Clemens had just admitted the accusations thrown to him, nobody would have a problem. It was difficult for Clemens to deny anything since Andy Petitte was there to contradict him.

Clemens was noted as vehemently denying any use of steroids or HGH despite his former trainer, Brian McNamee’s accusations.

During the notorious 2005 hearing, Davis was the chairperson of the House Government Reform Committee. Davis remembers McGwire’s implementation of his Fifth Amendment right against self-incrimination. He refused to answer questions about steroids, rather saying that he was there not talk about the past.

Davis welcomed the news that McGwire is back in baseball, this time as a hitting coach for the Cradinals. He thinks McGwire deserves another chance. It is about time that he comes back in the league after four years of self-imposed exile from the sport.

Davis left congress in 2008 and now works as a consultant for Deloitte.

From New York Daily News:

Former congressman Tom Davis, who once led the House committee that helped destroy the baseball legacies of Mark McGwire and Roger Clemens, says he applauds McGwire’s return but thinks Clemens was in denial when he testified before Congress.

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Since the late 1980s, many athletes have been linked to steroids and PEDs use. Perhaps, baseball is the sport with the greatest steroid controversies. Some of the biggest and greatest names in baseball have been linked to steroids use, especially in the BALCO scandal.

The most famous being Barry Bonds, who is well known for breaking Hank Aaron’s home run record. These days, he is also known for another thing, his association with steroids. Bonds, no matter how great his records are in baseball, could never get a contract with any MLB teams and spent all his 2008 with no activity.

In 2003, Bay Area Laboratory Cooperative was accused of supplying anabolic steroids, HGH and other performance-enhancing drugs to professional players in the MLB and in US Track and Field. Some of those athletes include Jason Giambi, Bill Romanowski and Marion Jones.

Added to the BALCO scandal was the list of 104 players who failed the drug test in 2003. The list was supposed to be kept confidential until federal authorities illegally seized the list during a BALCO related search.

Regardless of the advantages it could bring to an athlete’s professional career, the side effects could not be ignored. Its life-long effect in the reputation of professional sports can also be detrimental.

From Bleacher Report:

A new era of baseball is in progress. Pitchers with 210 strikeouts a season, hitters getting over 500 home runs a year with 40 stolen bases. All regular statistics nowadays, but are they legit?

Ever since the late 1980s many sports figures (mostly baseball) have been linked to PED’s (Performance Enhancing Drugs). Some of these athletes include the biggest names in baseball. Even though the testing and tolerance level has grown stricter and stricter over the years drug use has continued to increase

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Former Miss South Dakota 2008 Alexandra Hoffman says performance-enhancing drugs are harmful and at the same time illegal.

Being an athlete herself, she thinks that taking performance-enhancing substances is a form of cheating.

What is more concerning about steroids use is that it is not just related to athletics but ordinary young people also take it to lose weight, relax, build muscles or just enhance their overall body image.

Anabolic steroids and HGH are just two of the common performance-enhancing substances. However, other substances such as caffeine, diuretics and alcohol are being taken excessively by athletes.

Sometimes, athletes try to mask their steroids use during mandatory drug testing by taking another drug such as diuretics.

In the case of  HGH, it is quite hard to detect it since the body produces it naturally. The varying amounts of natural HGH on each individual makes it more difficult to detect.

Hoffman emphasizes that using these performance-enhancing substances brings unpleasant side effects such as mood swings, jaundice, hepatitis, depression and even tumors.

She cited Lyle Alzado, a graduate and an ex- football player of Yankton College, who attributed his brain lymphoma to long-time steroids use.

Think about not only the short-term effects of steroids use but also the long-term effect it could have to your body, Hoffman added.

From Yankton Press & Dakotan:

The bottom line, she said, is that performance-enhancers are “not worth the risk. … The drugs are going to provide you with a short-term gain, but think about the long-term loss, what you’re doing to your body.”

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In order to prevent harm and protect the public health, US Food and Drug Commissioner Margaret Hamburg announced their plans for a stricter implementation of FDA policies and regulations.

Recent cases involving illegal importation and sales, drug diversion, misbranding of drug products and mislabeling of nutritional supplements have kept the agency busy.

FDA conducted criminal investigations related to the above cases in partnership with other government offices.

Last July 27, Christopher Chase of Massachusetts received a sentence of three years imprisonment with three years of supervised release due to illegal importation of anabolic steroids and other performance enhancing drugs.

The drugs were sourced from China and sold in the United States by Chase and his team as bodybuilding substances through websites. Substances such as anabolic steroids, HGH and IGF-1 were available online without a prescription. Clenbuterol, a known drug not approved by the FDA for human consumption, was also among those drugs sold by Chase’s team.

According to Hamburg, the agency must be vigilant, strategic, and quick and must be visible these days.

Among the FDA’s plan include setting post inspection deadlines, speeding the Warning Letter process, and working more closely with regulatory partners of the agency.

According to PharmTech Talk:

Last month, US Food and Drug Administration Commissioner Margaret Hamburg announced the agency’s six-point plan for tougher enforcement of its policies and regulations as means of protecting public health. The plan, which includes actions like setting postinspection deadlines, speeding the Warning Letter process, and working more closely with FDA’s regulatory partners, was designed to “to prevent harm to the American people,” as Hamburg said in an FDA release.

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Many people would refer to Human Growth Hormone (HGH) as steroids. Actually, it’s not. Human growth hormone is a synthetic hormone.

For years, HGH has been promoted to increase healing following an injury or trauma, enhance athletic performance and increase cardiac output. Some even take HGH, which is believed to have anti-aging properties.

Professor John T. Wendt, Associate Professor in the Ethics and Business Law Department of the University of St. Thomas, a specialist in Sports Law and Olympics policies and business, explained the real effects of HGH, its side effects, and its impact in sports.

The major effect of HGH in the body is to stimulate the production and secretion of insulin. As insulin levels increases production of cartilage cells is stimulated. This results in bone growth and in organ growth.

Among the side effects of HGH include diabetes, muscle, joint and bone pain, abnormality in organ growth, hypertension, cardiac deficiency, accelerated osteoarthritis and worsening of cardiovascular diseases.

HGH is never permitted in and out of the competition, based on the World Anti-doping Authority rules.

There are cases, however, that steroids or PEDs use is permitted. A medical condition such as asthma is allowed by WADA to be treated with steroids such as Symbicort.

From the Examiner:

Professor Wendt reiterates that using HGH is not permitted under the World Anti-Doping Authority’s list of Prohibited Substances and it is not possible for one to obtain a therapeutic use exemption (TUE) for the hormone. Professor Wendt wrote, “The important thing to remember is that hGH is prohibited in both in- and out-of-competition. WADA uses a blood test to test for hGH and has been in use since the 2004 Olympic Games in Athens.”

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Human Growth Hormone, which is popularly known as HGH, can result in serious repercussions when abused as per recent study findings. It is important to note here that HGH was considered to be a safe product till now and still continues to be used in clinical treatment forms under qualified medical guidance as only an abuse can bring side effects.

Dr. Alan Rogol, who testified before the U.S. House of Representatives Government Reform Committee on behalf of The Endocrine Society, outlined the medical use (legitimate) of the growth hormone and its severe health risks when abused by sportsmen, individuals, and celebrities who try to find effective ways to keep aging away.

From News-Medical.Net:

“There are a number of safe and legitimate FDA-approved uses of growth hormone in adults and children,” said Dr. Rogol. “The off-label use of growth hormone, which primarily is in the anti-aging and body image or athletic market, comes with increased risks.”

One risk factor is that most off-label users are usually unaware of the correct doses. “One can assume that the dose administered would be much greater than that given for legitimate purposes,” said Dr. Rogol.

At higher HGH dosages, it is possible to achieve levels similar to those found in the endocrine disease acromegaly, which is caused by too much growth hormone in the body. This condition can lead to severe muscle weakness and even heart disease.

According to Dr. Rogol, perhaps the most insidious off-label use is by athletes and others who believe they are using actual growth hormone, when in fact they may be receiving an entirely different substance.

“Magazines and the internet are replete with advertisements for substances marketed as ‘growth hormone‘,” said Dr. Rogol. “Growth hormone, however, can only work if injected, and many of these preparations are taken orally, so they cannot possibly be HGH.”

It was remarked by Dr. Rogol that GH that is made from human tissue has now been almost removed from the drug market because of the rare yet fatal Creutzfeldt-Jakob disease.

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