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Friday 23, Apr 2010

  Interference with vagal nerve activity prevents hypertension and diabetes in mice

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Interference with vagal nerve activity prevents hypertension and diabetes in mice  According to scientists at Washington University School of Medicine in St. Louis, diabetes and hypertension in mice can be prevented by interrupting nerve signals to the liver. The finding was reported in an issue of the journal Cell Metabolism.

Clay F. Semenkovich, M.D., professor of medicine and of cell biology and physiology, said that interrupting vagal nerve signaling can prevent the development of hypertension and diabetes at least in mice.

Semenkovich remarked that he is not sure as of now if this works for humans but expect that alteration of vagal nerve activity can offer a novel approach to treat the common metabolic disorders.

Tuesday 02, Jun 2009

  Glucocorticoids Trigger Diabetes And Hypertension

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Glucocorticoids Trigger Diabetes And HypertensionSteroids called glucocorticoids are critical for treating diseases such as asthma, arthritis and pain syndromes, but they also can trigger diabetes and hypertension. In order to show why these drug exhibit such adverse reactions, a team from the Washington University School of Medicine in St. Louis conducted a study.

In the study, the researchers found out that a protein called peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is activated by fatty acids and appears to be important in the development of these problems. This helps explain the high incidence of diabetes and hypertension in obese individuals who have more glucocorticoids than average weight individuals.

The researchers believed that hypertension and diabetes happen to overweight people who also produce significantly higher glucocorticoids. So, if the person has excess glucocorticoids or if he is using this medication, he has greater risk of developing hypertension and diabetes.