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Friday 02, Jul 2010

  Steroids not effective for treating traumatic brain injuries

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Steroids not effective for treating traumatic brain injuriesIndividuals suffering from traumatic brain injuries should not be administered with steroids with an aim to reduce the associated inflammation, according to a research.

It is estimated that approximately 1.4 million individuals in the United States alone suffer from Traumatic brain injuries every year causing 50,000 deaths.

This finding was disclosed by researchers after comparing mortality rates among patients who received steroids to those who received a placebo.

Monday 14, Jun 2010

  Islet transplantation failure can be avoided by AAT

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Islet transplantation failure can be avoided by AATAccording to researchers from Ben-Gurion University of the Negev (BGU) in Beer-Sheva, Israel, treating diabetic animals with alpha-1-antitrypsin (AAT) after an islet transplantation procedure can prove useful to eliminate reasons behind failure of islet transplants.

It was remarked by Dr. Eli Lewis, director of the Clinical Islet Laboratory at BGU that use of a safe, non-toxic and non-steroidal drug can be made to effectively block inflammation by targeting multiple inflammatory molecules.

Treatment of diabetes with transplanted human pancreatic islet cells can help in restoring normal glucose levels besides relieving patients from injections of insulin.

Friday 14, May 2010

  Cardiac conduction disease can be caused by genetic mutation

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Cardiac conduction disease can be caused by genetic mutationA first molecular insight into cardiac conduction disease that is a disorder slowing down rhythm of the heart to necessitate pacemaker implantation in millions worldwide was noticed during studies that started in an Amsterdam emergency room.

Report’s senior author, Dr. Jeffrey R. Balser, associate professor of Anesthesiology and Pharmacology and holder of the James Tayloe Gwathmey Physician-Scientist Chair at Vanderbilt University, said that there was little or no guidance on the molecular mechanisms that may potentially contribute to acquired conduction disease-the type that affects people as they grow older.

The studies were supported by the Interuniversity Cardiology Institute Netherlands, the Dutch Heart Foundation, and the National Institutes of Health and the list of collaborators on the Nature report included Vanderbilt scientists Hanno Tan and Prakash Viswanathan, and researchers in Amsterdam and Groningen, the Netherlands: Margreet Bink-Boelkens, Connie Bezzina, Gertie Beaufort-Krol, Peter van Tintelen, Maarten van den Berg, and Arthur Wilde.

Thursday 13, May 2010

  AAT can overcome obstacles to islet transplantation

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AAT can overcome obstacles to islet transplantationTreatment of diabetic animals with alpha-1-antitrypsin (AAT) following an islet transplantation procedure can eliminate the inflammation that causes islet transplants to fail, as per researchers from Ben-Gurion University of the Negev (BGU) in Beer-Sheva, Israel.

Dr. Eli Lewis, director of the Clinical Islet Laboratory at BGU, remarked that inflammation can be effectively blocked using a safe, non-toxic and non-steroidal drug by targeting multiple inflammatory molecules. This process can literally modify the immune response to facilitate transplant acceptance for successfully treating diabetics and those at risk.

It was concluded that treatment of diabetes with transplanted human pancreatic islet cells could restore the normal levels of glucose besides reliving the patients from insulin injections.

Thursday 29, Apr 2010

  Molecule causing destructive lung inflammation identified

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molecule-causing-destructive-lung-inflammation-identifiedA protein critical to the development of inflammation during lung infection in patients with cystic fibrosis (CF) has been identified by scientists at Children’s Hospital of Pittsburgh of UPMC.

The protein, interleukin-23 (IL-23), is an important finding offering a specific target to the researchers for developing new therapies.

This research by Dr. Kolls and Children’s pulmonologist Patricia Dubin, MD, highlights that IL-23 is an important mediator to an inflammatory response.

Saturday 17, Apr 2010

  New antibiotic identified to speed up asthma recovery

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New antibiotic identified to speed up asthma recoveryA relatively new type of antibiotic has been identified that can provide quick relief from an attack of asthma, as per a study. It was, however, noted that more research is required before this antibiotic can be prescribed.

Asthma is a chronic ailment that affects millions around the world and leads to airway inflammation and disruptions in breathing.

Antibiotics are usually not recommended for treating asthma but some physicians prescribe them to patients suffering from asthma and experiencing respiratory problems, which are possibly because of bacterial infections.

Monday 01, Jun 2009

  Giant Cell Arteritis Cured By Using Steroids

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Giant Cell Arteritis Cured By Using SteroidsStudies have come up with a convenient treatment for patients suffering from giant cell arteritis (GCA). Researchers from the Emory University and the Mayo Clinic have found that by treating newly diagnosed GCA patients and keeping them on high-dose intravenous steroid for three days, patients relapsed less and were able to taper off an oral steroid usage. The patients significantly showed progress with less pain and withdrew symptoms.

Giant cell arteritis (GCA) is found to effect Caucasian women over the age of 50 years, there is no known cause or cure for this ailment. It is characterized by inflammation of arteries, primarily in the head and may lead to swelling and headaches, or, as it progresses, it may lead to vision loss, strokes and even aortic aneurysms.

Though scientists have been improving on treatments and methods to completely cure GCA however steroid therapy still remains the most effective option before them. “Even the modern and effective immunosuppressants do not improve the situation with these patients,” says Dr. Weyand. He mentioned that if doses of steroids are increased to very high levels, inflammation can be eradicated.

A double-blind human study was also examined to verify whether a brief period of pulsing with high-dose intravenous steroids soon after diagnosis could reduce the long-term need for prednisone and improve patient recovery. This study revealed that patients who had been given the initial high dosage had fewer relapses of the disease (21, as compared to 37 relapses). Seventy-one percent of the patients were also able to reduce their daily dose of prednisone to 5 milligrams after a year of treatment (compared to only 15 percent in the control group), avoiding the need for long-term steroids.

Sunday 31, May 2009

  Plantar Fasciitis Now Treatable By Steroids

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Plantar Fasciitis Now Treatable By SteroidsPatients suffering from plantar fasciitis now have a choice to choose above surgery. The new method developed by an Italian Team of researchers used dry-needling to combine it with a steroid injection.

Dry needling is done to reduce inflammation by causing local bleeding in the area where a steroid can be injected to the perifascial soft tissue, which helps in healing the fascia.

Till date, no proper treatment was established for this disease though stretching in the morning, weight loss, and NSAIDS were few things that were advised to the concerned patients. But after a number of clinical trials, researchers have come out with a conclusion that steroids help in reducing pain to a considerable extent.

The efficiencies of dry needling and steroids were assessed by researchers as they conducted a study of 44 patients in the age group of 35-80 years (who were unresponsive to previous therapies). The entire procedures took about 15 minutes. Patients were given local anesthesia guided by dry needling that was then pulled back to the perifascial soft tissues and 1 mL of triamcinolone acetonide 40 mg/mL was injected to reduce inflammation, Luca M. Sconfienza, M.D., of the University of Genoa, said.

This study has been seen as a progressive therapy for reduction of pain and associated symptoms. It is also believed that this is a novel method of treatment to cure even tennis elbow.