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Wednesday 09, Nov 2016

  George Sullivan Accepts Suspension Of One Year

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UFC fighter George Sullivan has accepted a sanction of one year after he was found violating anti-doping policy of the United States Anti-Doping Agency.

The UFC fighter never actually failed a drug test but admitted to using a substance or product with a banned item in it.

In a statement, USADA said that George Sullivan has accepted a one-year sanction for an anti-doping policy violation after declaring the use of a prohibited substance contained in a product that was inaccurately labeled. The statement further reads that Sullivan did not test positive for any prohibited substances but the admission of use of a prohibited substance or product containing a prohibited substance is regarded as an anti-doping policy violation under the UFC Anti-Doping Policy.

The 35-year-old declared the use of Insulin-like Growth Factor-1 (IGF-1) on his sample collection paperwork when he described his use of a deer antler velvet product during an out-of-competition test conducted on July 13, 2016.

Insulin-like Growth Factor-1 is a prohibited substance in the class of Peptide Hormones, Growth Factors, Related Substances, and Mimetics, and prohibited at all times under the UFC Anti-Doping Policy that has adopted the World Anti-Doping Agency (WADA) Prohibited List. USADA initiated an investigation following the declaration of Sullivan regarding the product declared by him on his sample collection paperwork. Sullivan provided the United States Anti-Doping Agency with information about the supplement product he was referring to when he declared IGF-1.

It was found by USADA that the manufacturer claimed on the product website that each bottle of the product contains an extremely high concentration of IGF-1 although no prohibited substances were specifically listed on the Supplement Facts label. The presence of IGF-1 in the product was confirmed by detailed analysis by the WADA-accredited laboratory in Salt Lake City, Utah. This product has since been added to the list of high risk supplements maintained on USADA’s online dietary supplement safety education and awareness resource – Supplement 411 (www.supplement411.org).

An athlete’s period of ineligibility for using a prohibited substance may be decreased under the UFC Anti-Doping Policy, as well as the World Anti-Doping Code if the athlete lacks significant fault for the anti-doping policy violation. USADA determined in the case of Sullivan that the UFC fighter’s degree of fault and his forthright declaration of the product at issue justified a reduction to one year from the maximum two-year period of ineligibility.

The one-year period of ineligibility of George Sullivan began on January 31, 2016, the day after his most recent UFC bout. USADA said the first time Sullivan disclosed that he was using the product was back in January, which is why his suspension is retroactive to that date.

The American mixed martial artist competing in the Welterweight division of the Ultimate Fighting Championship signed with the UFC in the winter of 2013 after winning the Cage Fury Fighting Championships Welterweight Championship. In his promotional UFC debut, Sullivan fought against fellow newcomer Mike Rhodes on January 25, 2014 at UFC on Fox 10 and won the fight via unanimous decision. Sullivan faced Igor Araújo in his next fight and won the bout via knockout in the second round.

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Sunday 19, Jan 2014

  Rodriguez Meticulous With Doping, Says Bosch

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Rodriguez Meticulous With Doping, Says Bosch

Anthony Bosch, the founder and former proprietor of the infamous anti-aging clinic Biogenesis, has remarked Alex Rodriguez was meticulous in his quest to exploit the advantages of performance enhancing drugs to gain a distinctive edge. Bosch said Rodriguez, the American baseball third baseman for the New York Yankees of Major League Baseball, wanted to become the sole member of the 800 home run club.

Speaking in an interview with the CBS News program 60 Minutes, Bosch said he personally injected the New York Yankees third baseman with performance enhancing drugs as A-Rod was “scared of needles.” According to a publicity release, Bosch said in the interview that Alex would ask him to inject at times. The 60 Minutes segment also disclosed that the baseball star spent $12,000 a month in doing business with Bosch, who claimed the most important objective of A-Rod was the 800 home run club. Bosch featured alongside Major League Baseball’s Rob Manfred in the CBS News program 60 Minutes.

The three-time American League MVP was the biggest name along with one-time MVP Ryan Braun of the Milwaukee Brewers. Recently, the 211-game suspension of Rodriguez from Major League Baseball was lowered by an arbitrator to 162 games, plus any 2014 playoff games. Arbitrator Fredric Horowitz reduced the suspension imposed on Rodriguez’, originally levied by Major League Baseball in August 2013, from 211 to 162 games and ordered that the New York Yankees third baseman be banned from any 2014 postseason games as well. In a lawsuit, MLB had claimed that Biogenesis and Bosch, along with others, created a violation of the players’ contracts by supplying them with banned performance enhancing substances. Rodriguez has never tested positive for a banned substance since he joined the New York team.

Bosch told CBS anchor Scott Pelley that he personally delivered banned substances including testosterone, insulin-like growth factor 1, and human growth hormone to Alex Rodriguez at least a dozen times and the baseball star paid him $12,000 a month in cash. Bosch added that A-Rod asked him for what he gave MLB superstar Manny Ramirez, a former Bosch client. Bosch also claimed that the associates of Alex Rodriguez tried to intimidate him for preventing him from helping with the MLB investigation into the player. Manfred told Pelley during the interview that he believes the threats Bosch said he received could be legitimate. He added the concerns seemed credible, particularly given that he identified individuals that we had our own concerns about, said Manfred.  Bosch also showed text messages between A-Rod and himself that demonstrated that the two at times were in contact daily.

MLB’s COO Rob Manfred and MLB dropped a lawsuit against Bosch and they are now paying for security guards for Bosch. They have agreed to cover his legal fees in return for his cooperation.

The 38-year-old Rodriguez issued a statement that said he had been clear that he did not use performance enhancing substances as alleged in the notice of discipline, or violate the Basic Agreement or the Joint Drug Agreement in any manner, and in order to prove it he will take this fight to federal court.

pdf_iconDownload in PDF: Rodriguez Meticulous With Doping, Says Bosch

Monday 13, Feb 2012

  IGF-1

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If you are looking for a highly potent performance enhancing drug, IGF-1 or Insulin-like Growth Factor 1 is the best drug for you. This is not just because IGF-1 is extremely useful to promote balanced growth and development of muscle, liver, kidney, skin tissue, lungs, cartilage, bone, and nerves but also because it is second to none to improve healing, muscularity, and recovery time associated with intense workouts.

One of the biggest advantages associated with IGF-1 is that it prevents insulin from transporting glucose across the cell membranes. Sportsmen admire Insulin-like Growth Factor 1 because it helps them bridge between steroid cycles and is undetectable by both blood and urine tests as injectable IGF-1 never enters the bloodstream. In addition to these benefits, it is extremely beneficial for preventing signs of aging such as wrinkles and promoting new tissue growth and improving the level of sexual performance. IGF-1 is also useful in reducing body fat and promoting lean muscle mass and is medically prescribed to individuals suffering from stunted growth and deficiency of growth hormone.

In the world of professional sports, IGF-1 is also admired for its unique ability to promote the sense of well being, reducing breakdown of proteins, and improving transportation of protein into cells. The performance enhancing drug is also associated with dramatic improvements in the context of white blood cell production and reducing the level of LDL (bad) cholesterol besides facilitating dramatic enhancements in terms of muscle fibers, hyperplasia, nerve tissue repair, and providing significant relief to burn victims and individuals afflicted with AIDS wasting.

The recommended dose of IGF-1 is 20-120 mcg per day, with or without meals. It should be used for a period of fifty days and its use can be reinitiated after a gap of twenty to forty days. IGF-1 is not recommended for lactating and pregnant women and its abuse can lead to side effects such as oily skin and fatigue. IGF-1 must be stored at a controlled room temperature of 20° to 25°C (68° to 77°F) with excursions permitted to 15° to 30°C (59° to 86°F) for protecting its shelf life.

Tuesday 24, Jan 2012

  IGF-1

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Somatomedin C is a protein found in humans and is commonly termed as Insulin-like growth factor 1 (IGF-1).  It is one of the most important hormones responsible for growth in children and has a molecular structure and size similar to that of Insulin.  It has a molecular weight of 7649 daltons and consists of a peptide chain with 70 amino acids in a single chain having three intramolecular disulphide bridges.

It is associated with the peptide family, commonly identified as the growth factors. Known to be a highly anabolic hormone, it is produced in liver and the peripheral tissues particularly in the cells of skeletal muscles. The presence of the Human Growth Hormone (HGH) in the body is considered to trigger the release of IGF-1 as its response. It is one of the most sought after substances by bodybuilders for the reason that it initiates the development of muscles in a very short period. As a result of rigorous training, the body experiences an increase in the Growth Hormone (GH) as well as the IGF-1 which causes the muscle cells to grow. Where GH is considered to have very strong anabolic properties, it is IGF which is believed to be responsible for its primary anabolic nature.

Growth hormone is mainly produced in the anterior pituitary gland which then flows into the blood stream stimulating the liver to produce IGF-1.  As a result, IGF-1  then  leads to the systemic body growth  of all the cells in the body mainly those of the  skeletal muscles, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell and the lungs. Apart from IFG’s insulin-like effects, IGF-1 also initiates regulated cell growth and development in the nerve cells and cellular DNA synthesis.

Deficiency of any of these two substances causes stunted growth in children who are then given recombinant GH to restore their condition.  People suffering from IGF-1 often suffer from Laron syndrome (Laron’s dwarfism) and are treated with recombinant IGF-1.

Normally 98% of IGF-1 is always seen to be bound to one of 6 binding proteins (IGF-BP).  The protein responsible for 80% binding of IGF is IGFBP-3and is bound to it in 1:1 molar ratio.

When administered, IGF-1 leads to the building of new muscle tissue by initiating the synthesis of protein along with the retention of nitrogen in the body. The prime functions associated with this are hyperplasia, which causes an increase in the muscle tissue and mitogenesis or the growth of new muscle fibers. This makes IGF -1 a highly favoured option for bodybuilders and power lifters seeking not only their muscle development but growth of muscle fibers as well.

Another benefit of employing IGF-1 is that it has a strong effect on the lipid metabolism of the body. In other words, it also plays a significant role in burning the body fat at a relatively fast rate. IFG-1 is also known to be a neuroprotector as well as a neuropromotor and finds its use in the improvement of functions related to the mind like reflexes, memory and ability to learn.

IGF-1 is employed as one of the most important substances required for the production of connective tissue in the joints, thereby ensuring appropriate bone density.

Being a highly potent drug for the development of muscle mass and fat-cutting, IGF’s Lr3 IGF-1 version is also considered to be equally powerful. Here Lr3IGF-1 stands for Long R3 Insulin-like Growth Factor-I or Long R3IGF-I.  It is a peptide of 83 amino acid analog of human IGF-I consisting of an entire human IGF-1 sequence. However, the only difference is that there is a substitution of an Arg for the Glu at position 3 and 13 amino acid extension at the N-terminus of the peptide.  It is for this reason that Long R3IGF-I is comparatively considered to be a more potent drug.

Some factors believed to cause changes in the levels of growth hormone (GH) and IGF-1 are the user genetic make-up, time of the day it is taken, age, sex, exercise status, stress level, nutrition level and body mass index (BMI). Reduction in IGF-1 signaling is also associated with the contribution of ‘anti-aging’ effects during calorie restriction phase.

A word of caution here is that increased use of IGF is often associated with enhanced risk of cancer.

Saturday 17, Jul 2010

  Potential form of treatment found effective for muscle atrophy

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Potential form of treatment found effective for muscle atrophyA potential, new form of treatment has been identified to treat individuals afflicted with muscle atrophy. This finding was disclosed by an animal study that was presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C.

According to study co-author Andrea Graziani, PhD and molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy, some of the presently prescribed treatment options for the complication include anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1) that may not be all that safe.

It was suggested by the researchers that des-acyl ghrelin, the appetite-stimulating hormone found in the body, could be useful as it offers a direct anti-atrophic activity on the skeletal muscle of mice for the complication that is usually caused injury to the nerves or fasting.

Monday 15, Feb 2010

  Hormone stimulating appetite found useful for muscle atrophy

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Hormone stimulating appetite found useful for muscle atrophyA new treatment form has been identified to provide significant relief to people suffering from muscle atrophy, as per the results of an animal study that were presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C.

Study co-author Andrea Graziani, PhD, molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy, said that some of the presently prescribed options including anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1) cannot be termed as completely safe.

The researchers noted that the appetite-stimulating hormone, des-acyl ghrelin, poses a direct anti-atrophic activity on mice’s skeletal muscle caused by fasting or nerve injury.

Monday 11, Jan 2010

  Muscle atrophy can be effectively cured with appetite-stimulating hormone

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Muscle atrophy can be effectively cured with appetite-stimulating hormoneA new form of treatment with des-acyl ghrelin, an appetite-stimulating hormone, can prove to be effective when it comes to offering relief to patients suffering from muscle atrophy, as per results of an animal study that were presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C.

Muscular atrophy is a debilitating process that reduces quality of life besides resulting in extensive loss of muscle function and mass.

According to study co-author Andrea Graziani, PhD, molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy, some of the currently recommended treatment options including anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1) cannot be termed as safe.

It was remarked by the involved researchers that the appetite stimulating hormone can be effective in providing a direct anti-atrophic activity on mice’s skeletal muscle that is caused by nerve injury or fasting.

Friday 08, Jan 2010

  Hormone responsible for stimulating appetite can treat atrophy

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muscleAccording to the results of an animal study that were presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C., a new treatment option for providing relief to patients with muscle atrophy has been identified by the researchers.

Muscular atrophy can be classified as a debilitating process that results in an extensive loss of muscle function and mass causing in reduced quality of life. Some of the presently used treatment options include anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1), which does not appear to be safe, as per study co-author Andrea Graziani, PhD, molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy.

It was remarked by the involved researchers that des-acyl ghrelin, appetite-stimulating hormone, offers a direct anti-atrophic activity on the skeletal muscle of mice for the ailment that happens by fasting or nerve injury.

Thursday 03, Dec 2009

  Des-acyl ghrelin can treat muscle atrophy

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Des-acyl ghrelin can treat muscle atrophyAccording to results of an animal study presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C., Des-acyl ghrelin can treat muscle atrophy to a considerable extent. It is important to note here that Des-acyl ghrelin is an appetite-stimulating hormone.

Muscle atrophy is a debilitating process that results in extensive loss of muscle function and mass besides reducing the life quality of patients suffering from it.

Some of the presently used treatment options consist of anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1), which may not be completely safe according to study co-author Andrea Graziani, PhD, molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy.

 

 


Sunday 27, Sep 2009

  Appetite-stimulating hormone can prove effective for muscle atrophy

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Appetite-stimulating hormone can prove effective for muscle atrophyAccording to results of an animal study that were presented at the Endocrine Society’s 91st Annual Meeting in Washington, D.C., a new form of treatment has been discovered for providing relief to patients suffering from muscle atrophy.

Muscular atrophy is a debilitating process that causes an extensive loss of muscle function and mass and considerably reduces quality of life in patients.

It is noteworthy to note here that some of the present-day treatment methods include anabolic steroids (testosterone) and insulin-like growth factor 1 (IFG-1) that may not appear to be safe, according to study co-author Andrea Graziani, PhD, molecular biologist with the Department of Clinical and Experimental Medicine and the Biotechnology Center for Applied Medical Research, University of Piemonte Orientale, Novara, Italy.

The involved researchers said that des-acyl ghrelin provides a direct anti-atrophic activity on mice’s skeletal muscle that is caused by nerve injury or fasting.

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