New mechanism identified for setting apart males and females  A new mechanism has been identified by Walter Wahli and colleagues, at the University of Lausanne, Switzerland underlying the differential expression of proteins in male and female mice.

Expression of liver proteins controls a varying number of whole-body processes like energy generation, and lipid and steroid hormone production and turnover.

The research appeared in September 1, 2009 issue of the Journal of Clinical Investigation.

It was suggested by the authors that PPAR-alpha agonists might provide a new approach to prevent estrogen-induced intrahepatic cholestasis, the most common liver disease during pregnancy.