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Thursday 20, May 2010

  New treatment insights for patients with Severe Alcoholic Hepatitis

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New treatment insights for patients with Severe Alcoholic HepatitisPatients with severe or acute alcoholic hepatitis can expect significant relief after results from two French studies were presented at the International Liver Congress TM 2010 press conference.

Professor Philippe Mathurin from the Hôpital Huriez, CHRU Lille, France who presented the results, said that as researchers and clinicians, we have a responsibility to treat patients in the best possible way and highlight new treatment options.

It was disclosed that deaths for C+NAC group were significantly lower at month 1 and the survival rate was increased to some extent at month 2 and 6 for that patient group.

Sunday 28, Mar 2010

  Liver transplant survival adversely affected by alcohol relapse

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Liver transplant survival adversely affected by alcohol relapseA study has found that alcohol relapse adversely affects survival rates after liver transplantation, only after 10 years.

The study results appeared in Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). This journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

The study authors said that risk-reducing measures like quitting smoking and abstaining from alcohol must be encouraged in the affected patients.

Wednesday 10, Feb 2010

  BMI alarming cause in liver transplantation incidents

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bmi-alarming-cause-in-liver-transplantation-incidentsAccording to a study by doctors at the University of Washington, patients who are significantly obese or underweight before transplantation of the liver face an increased of death.

The study findings were presented in an issue of Liver Transplantation, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.

It was suggested by the researchers that there is a need for more aggressive immunosuppressive regimen with higher doses of mycophenolate mofetil and tacrolimus for providing relief to the patients.

Wednesday 23, Sep 2009

  BMI extremes a concerning cause in liver transplantation

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BMI extremes a concerning cause in liver transplantationAccording to a recent study by doctors at the University of Washington, patients who are considerably underweight or very severely obese before liver transplantation are at an increased risk of death following the transplantation surgery.

These findings have been published in the August issue of Liver Transplantation, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.

The doctors suggested a more aggressive immunosuppressive regimen with higher doses of mycophenolate mofetil and tacrolimus.

Wednesday 02, Sep 2009

  Higher rejection incidence keenly associated with early steroid withdrawal

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Higher rejection incidence keenly associated with early steroid withdrawalAccording to a new study, there is a high incidence of rejection and low incidence of intolerance necessitating treatment for diabetes in human beings when it comes to early steroid withdrawal following liver transplantation.

The results of this first double-blind placebo-controlled study were published in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS) and were focused on examining the effects of early steroid elimination.

It was concluded by the involved authors that early steroid withdrawal at day 14 cannot be termed as a safe practice though this practice is efficient in terms of tolerability to glucose.

Wednesday 26, Aug 2009

  Higher rejection incidence following early steroid withdrawal

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Higher rejection incidence following early steroid withdrawal  According to a new study on early steroid withdrawal following liver transplantation, it has been revealed that there is a high incidence of rejection and a low incidence of intolerance that necessitates treatment for diabetes. This first double-blind placebo-controlled study was conducted to examine the effects of early steroid elimination.

The results of this study were published in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

From Eurekalert.org:

The normal course of treatment after liver transplantation includes calcineurin inhibitors (a class of immunosuppressants) and steroids to minimize rejection and improve survival rates, but the long-term complications of these drugs can be fatal. Steroid use in particular can lead to diabetes, high cholesterol and hypertension, which increase the risk of heart disease, and can lead to death. Several previous studies have reported that early withdrawal from steroids reduced the incidence of these side effects, but that rejection increased, although it could be controlled with steroid pulse therapy (in which high doses of steroids are administered intravenously for a short period of time). The current multicenter study was the first prospective double-blind, placebo-controlled trial to compare early steroid withdrawal with continued use.

Led by Georges-Philippe Pageaux, of the Centre Hospitalier University St.-Eloi in Montpellier, France, the study examined 174 patients in 15 French liver transplantation centers over a 14-month period from December 1999 to August 2001. The patients were randomly divided into two groups seven days following transplant: 90 of them continued to receive steroids for six months, while 84 received a placebo starting at day 14 (following 7 days of tapering from steroids). At the end of six months, 22 patients in the steroid group (24.4 percent) and 32 patients in the placebo group (38.1 percent) experienced acute rejection. Although there was no statistical difference in the two groups for high cholesterol and hypertension, 22.2 percent of patients in the steroid group developed diabetes compared with 14.3 percent of placebo patients. At the end of 12 months, the incidence of acute rejection was 25.6 percent in the steroid group versus 39.3 percent in the placebo group, but there no longer a difference in diabetes between the two groups.

The authors concluded that early steroid withdrawal at day 14 is not considered to be completely safe in terms of rejection but it was also found that it is efficient in terms of glucose tolerability.