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Wednesday 08, Sep 2010

  Biological rationale behind success of steroids to treat lupus explained

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Biological rationale behind success of steroids to treat lupus explainedThe biological rationale for why large doses of corticosteroids given repeatedly over several weeks may help individuals with lupus has been uncovered by researchers at UT Southwestern Medical Center.

Lupus is a chronic inflammatory disease that affects more than 1 million people in the United States. Unlike the anabolic steroids abused by athletes for bulking up muscles, corticosteroids are routinely used to treat inflammation in lupus patients.

Dr. Marilynn Punaro, professor of pediatrics at UT Southwestern and co-author of the study and director of the pediatric rheumatology division at UT Southwestern, said that steroids are probably always going to be a short-term fix because they work fast and powerfully.

Wednesday 21, Jul 2010

  B-cell depletion therapy effective for treating refractory patients

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B-cell depletion therapy effective for treating refractory patientsAccording to a study presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain, 36 percent of patients afflicted with refractory systemic lupus erythematosus (SLE or lupus) could notice improvements after undergoing B-cell depletion therapy (BCDT) and do not feel or need standard immunosuppressive agents in the future.

It is worth noting here that reducing the number of B-cells in the system by B-cell depletion therapy is considered as a potential therapy for SLE patients who are unresponsive to other forms of treatment.

It was revealed by co-author of the paper, Professor David Isenberg, from University College London in the United Kingdom that the study results are encouraging and demonstrate that BCDT could be rated as a promising therapeutic option for lupus patients and is effective to reduce the need for continuous immunosuppressive therapy.

Wednesday 30, Jun 2010

  Lupus patients to benefit from Rituximab

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Lupus patients to benefit from RituximabA drug presently used for treating cancer patients could be used to treat patients with lupus and suffering from complications of the central nervous system, as per rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria.

The drug, Rituximab, is effective to provide relief to patients afflicted with lupus and could be considered as a gentle form of treatment that can last up to a period of six months with little to no side effects, according to Clinical professor Michael Neuwelt, at the University of California San Francisco and Stanford University.

Lupus is a health complication characterized by reduced quality of life and symptoms such as pain, inflammation, and diffused damage to many body organs.

Tuesday 08, Jun 2010

  Mysterious disease behind self-attack by immune system

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Mysterious disease behind self-attack by immune systemA mysterious disease has been identified by physicians at the University of Florida. This disease leads to a self-imposed attack by the immune system on itself along with sending a warning signal to alert doctors at the onset of its worst symptoms.

Doctors are still unaware about an option for identifying which all of their patients have this unpredictable autoimmune disorder lupus with dangerous and life-threatening aspects, as per the Lupus Foundation of America.

Lupus, the disease, is a result of overactivity of immune system of the body and doctors generally prescribe immunosuppressant drugs for kidney disease treatment, including steroids, for treating this complication.

Saturday 08, May 2010

  Mysterious disease causes immune system to attack itself

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Mysterious disease causes immune system to attack itselfPhysicians at the University of Florida have found that a mysterious disease can cause immune system of the body to turn against itself besides sending a warning signal for alerting doctors at the onset of its worst symptoms.

According to the Lupus Foundation of America, doctors are still unaware about a method to identify which of their patients have the unpredictable autoimmune disorder lupus with dangerous and life-threatening aspects.

It is important to note here that since lupus is a result of overactivity of the body’s immune system, doctors prescribe immunosuppressant drugs for kidney disease treatment, including steroids.

Friday 30, Apr 2010

  B-cell depletion therapy can help refractory patients in remaining stable

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b-cell-depletion-therapy-can-help-refractory-patients-in-remaining-stableThirty six percent of patients suffering from refractory systemic lupus erythematosus (SLE or lupus) remain well after undergoing B-cell depletion therapy (BCDT) without feeling or requiring the need of further standard immunosuppressive agents. This finding was disclosed by a study presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

It is important to note here that minimizing the number of B-cells in the system by BCDT has been suggested as a potential therapy to SLE patients unresponsive to other treatments.

Co-author of the paper, Professor David Isenberg, from University College London in the United Kingdom, said that results are encouraging and suggest that B-cell depletion therapy is a promising therapeutic option for lupus patients besides reducing the need for continuous immunosuppressive therapy.

Wednesday 14, Apr 2010

  Patients suffering from lupus get relief with Rituximab

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Patients suffering from lupus get relief with RituximabRituximab, which is currently indicated to patients suffering from cancer, can also prove effective for providing relief to patients with lupus and suffering from complications of the central nervous system, as per rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria.

Lupus is an immune system disorder that characterizes an attack by the human body on itself leading to diffused damage to several body organs besides resulting in inflammation and pain.

Clinical professor Michael Neuwelt, at the University of California San Francisco and Stanford University, said that Rituximab proves effective and may be classified as a gentler treatment form, which can last up to six months with a low risk of any side effect.

Friday 19, Mar 2010

  Psoriasis treatment possible with lupus drug

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Psoriasis treatment possible with lupus drugScientists from the University of Michigan have reported that a compound called benzodiazepine-423 (Bz-423) suppresses growth of cells in a model of psoriasis.

This study available online in the Journal of Pharmacology and Experimental Therapeutics suggested that Bz-423, which is known to minimize harmful side effects of the autoimmune disease lupus, can also be effective in treating psoriasis.

This study was led by Gary Glick, who is the Werner E. Bachmann Collegiate Professor of Chemistry and a professor of biological chemistry in the U-M Medical School. Glick’s coauthors on the paper were James Varani, professor of pathology; Narasimharao Bhagavathula, a research investigator in the pathology department; Hilary Scherzer and Kevin Fay, research associates in pathology; Kent Johnson, professor of pathology; Sewon Kang, professor of dermatology; and Anthony Opipari, assistant professor of obstetrics and gynecology.

Friday 05, Feb 2010

  Rituximab highly effective for providing relief to lupus patients

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Rituximab highly effective for providing relief to lupus patientsA drug that is presently used for treating cancer may prove additional worth for treating lupus and complications of the central nervous system.

Rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria, discovered that Rituximab can be highly effective for treating patients with lupus.

Lupus is a disorder of the immune system in which the body attacks itself resulting in severe pain, diffused body organ damage, and inflammation besides reducing life quality of patients.

Clinical professor Michael Neuwelt, at the University of California San Francisco and Stanford University, said that Rituximab is an effective drug that may be recommended as a gentle option for treatment lasting up to six months and with reduced side effect risk.

Friday 18, Sep 2009

  Rituximab offers a new hope for lupus patients

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Rituximab offers a new hope for lupus patientsAccording to rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria, Rituximab that is presently used to treat cancer can also prove its worth when it comes to treating patients with lupus and suffering from complications of the central nervous system.

Lupus is a disorder of the immune system in which the human body attacks itself resulting in pain, inflammation, and diffuse damage to many body organs. Medical studies have proved that lupus can dramatically minimize the life quality of patients to add to the misery.

It was remarked by Professor Neuwelt that Rituximab appears to very efficacious and can be described as a gentler form of treatment capable of lasting up to 6 months with a low risk of any side effects.

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