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Thursday 06, May 2010

  Pulsed steroids not effective for treating Kawasaki disease

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Pulsed steroids not effective for treating Kawasaki diseaseDuring a multicenter US trial representing the first randomized & placebo-controlled evaluation of the addition of pulsed steroids to the standard regimen to treat Kawasaki disease (KD), it was found by the authors that there is no benefit in terms of improvements of coronary artery results by going for primary therapy with a pulse of methylprednisolone among children with Kawasaki’s disease.

It was, however, noted during the study that subjects in the group of steroids experienced reduced sedimentation rates and were discharged early from hospitals besides having lower C-reactive protein levels when compared to usual care subjects.

The primary interest outcome was the z score of coronary artery diameter at five weeks post-treatment after use of larger of the values for the left anterior descending or the right coronary artery.

Monday 05, Apr 2010

  Steroid use for dizziness under the scanner

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Steroid use for dizziness under the scannerA new study has suggested that steroids could prove to be an effective option for treating vestibular neuritis that leads to dizziness due to a viral infection of the vestibular nerve.

The study was aimed to examine if a steroid drug, antiviral agent, or a combination of the two can improve the outcome of patients with vestibular neuritis.

The researchers said that methylprednisolone alone considerably improve recovery of patients with vestibular neuritis.

Monday 22, Feb 2010

  MS drug and steroids can redefine treatment by reducing disease activity

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MS drug and steroids can redefine treatment by reducing disease activityDisease activity related with multiple sclerosis (MS) is reduced to a considerable extent when a combination of steroid drugs and MS drug is administered to patients, as per a study presented as a part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting in Seattle.

Study author Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark, said that the study noted that both the drugs seem to have a synergy when taken together for providing improved beneficial effect on the disease activity as against use of the MS drug in isolation.

Friday 29, Jan 2010

  Steroid drug addition to MS treatment effective for reducing disease activity

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Steroid drug addition to MS treatment effective for reducing disease activityThe use of a steroid drug, methylprednisolone, in addition to a multiple sclerosis (MS) drug can prove to be a more effective combination for reducing the volume of disease activity than the use of MS drug alone.

This finding was presented as part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting in Seattle, April 25 – May 2, 2009.

Study author Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark, remarked that the results suggest that both drugs seem to have a synergy when taken as a combination and offer a more beneficial effect on the disease activity.

Monday 14, Dec 2009

  Steroid drugs added to MS treatment can reduce disease activity

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Steroid drugs added to MS treatment can reduce disease activityThe addition of a steroid drug, methylprednisolone, to the multiple sclerosis (MS) drug can significantly reduce the amount of disease activity more than what could have been experienced with the use of MS drug in isolation, as per a presented study as part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting in Seattle.

The study results clearly suggest that the two drugs, steroid and MS, can bring synergy when taken as a combination and provide a greater beneficial effect on the disease activity than MS drug alone, according to study author Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark.

 

 

 



Monday 30, Nov 2009

  Addition of steroids drugs to MS treatment can reduce disease activity

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Addition of steroids drugs to MS treatment can reduce disease activity  When steroid drugs are added to multiple sclerosis (MS) treatment, the risk of disease activity gets reduced to a considerable extent as per a study presented as a part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting in Seattle.

It was remarked by study author Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark, that results of this study highlight the fact that the two drugs tend to bring synergy in a combination and provide an improved beneficial effect on the disease activity as against use of the MS drug in isolation.

 


Thursday 30, Jul 2009

  Reduce MS activity found during steroid administration

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Reduce MS activity found during steroid administrationThe Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark conducted a study of adding methylprednisolone in the treatment of multiple sclerosis (MS) patients.

The study involved patients with relapsing-remitting MS and who had the disease for an average of three years. The treatment group received both interferon and methylprednisolone, while the control group received the interferon drug and a placebo. The study lasted for three years and the participants were only seen every three months.

The researchers measured the size of the brain lesions at the initial phase and again after a period of three years. They found that those in the treatment group, their lesions either stayed the same size or it shrunk while the lesions grew in size for those in the control group. The sign of disease activity is measured primarily by the size of the lesion in the brain.

Furthermore, those who received both drugs have fewer incidences of relapses while those receiving interferon only have a 38% higher rate of relapse. In terms of MS disability tests, the treatment group improved slightly higher than the control or placebo group.

These results might be an indication that there is a synergy between the two drugs which can provide more benefits than interferon alone.

According to Science Daily:

“These results indicate that these two drugs may have a synergy when taken together and provide a more beneficial effect on the disease activity,” said study author Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark. “This is a promising finding, as the benefit from interferon is only moderate and not everyone responds fully to the treatment, so anything we can do to boost those results is positive.”

Friday 05, Jun 2009

  Intravenous Steroid Injection for Treating Ear Disorder

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Intravenous Steroid Injection for Treating Ear DisorderAs per a recent study, steroid treatment is an effective form of treatment for patients suffering from sudden sensorineural hearing loss (SSNHL). It initially occurs in one ear and generally causes a 30+ decibel (dB) hearing loss at three consecutive frequencies within a time period of three days.

Scientists from Spain presented a new study which evaluated the effect of intratympanic steroid injections in patients with SSNHL. Studies was conducted on 50 patients diagnosed with unilateral (affecting one ear) SSNHL due to unidentified reasons. Hearing improvement of 15 dB or more in PTA was noted in 32 cases (64 percent) by the intravenous treatment.

There were no statistical differences in age, sex ratio, time of onset to therapy, presence of vertigo and tinnitus, initial hearing level, and final hearing level after intravenous treatment between the two groups.

The intratympanic methylprednisolone significantly improved the outcome of SSNHL by non-randomized clinical trial showed after intravenous steroid treatment. The therapy including intratympanic steroids was termed as a useful and safe therapy for SSNHL cases that are refractory to standard treatments.

Randomized prospective clinical trials were defined as the researchers suggested that the number of injections, the types of steroids, and the most adequate doses must be definite in their nature. Evidence-based treatment for idiopathic SSNHL was also established by this study. Evaluated results compared initial therapy for SSNHL and steroids that were administrated systemically or by intratympanic injections were mush effective.

Saturday 30, May 2009

  Methylprednisolone Improves Recovery Of Vestibular Neuritis Patients

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Methylprednisolone Improves Recovery Of Vestibular Neuritis PatientsA steroid medication called methylprednisolone helps the recovery of vestibular neuritis patients. This was the finding in a study that included 141 patients who have vestibular neuritis. The patients were divided into several groups. One group was given methylprednisolone, another group was administered with antiviral agent, and the other group was given placebo.

Three days after the treatment, the researchers made a follow up with the patients, and another follow-up 12 months after the treatment.

Researchers found out that 62% of the patients on the steroid improved compared to 39% in the placebo group, 36% in the antiviral group and 59 percent in the combination group. This shows that corticosteroids particularly methylprednisolone, significantly improved the recovery of vestibular neuritis patients.

Thursday 21, May 2009

  Steroids and MS Drugs to treat Multiple Sclerosis

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Steroids and MS Drugs to treat Multiple SclerosisAs per a recently concluded study, a combination of steroids and multiple sclerosis (MS) drugs to treat MS can minimize the amount of disease activity more than a MS drug alone. This study was a part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting that was conducted in Seattle, Washington from April 25 – May 2, 2009.

Multiple Sclerosis, also known as encephalomyelitis disseminata, is an autoimmune condition in which the human body’s immune system poses an attack to the central nervous system. Such an attack leads to demyelination (damage of myelin sheath of neurons). Impairments of movement, cognition, and sensation are some of the possible ailments after a demyelinating disease.

This means that the steroid drug methylprednisolone can now be used as an ongoing treatment along with being used to treat acute MS attacks. The above statements also suggest that a combination of steroids and multiple sclerosis (MS) drugs to treat MS offers a more beneficial effect on the disease activity than what can be offered by a MS drug alone.

These findings are expected to offer a sigh of relief to all those patients who were fighting a lone battle against Multiple Sclerosis.

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