Cancer drug Treanda, in combination with steroids like prednisone or dexamethasone, could be effective in elapsed and refractory multiple myeloma patients.

The finding was revealed by a recent French analysis and the researchers recommended that Treanda (bendamustine) be considered as a treatment option for patients with advanced multiple myeloma.

From Myelomabeacon.com:

Treanda is an alkylating agent, which causes cancer cell death by damaging the cancer cells’ DNA.  The drug, which was originally developed in East Germany in the 1960s, is currently approved by the FDA to treat certain types of leukemia and lymphoma.

Treanda also is approved in a number of European countries to treat multiple myeloma in patients older than 65 years who are not eligible for stem-cell transplantation and cannot be treated with thalidomide (Thalomid) or Velcade (bortezomib).

Cephalon Inc., the company that markets Treanda in the United States, is currently sponsoring several Phase 1 and Phase 2 clinical trials that are investigating Treanda as a multiple myeloma treatment. In a recent Phase 1 trial, Treanda showed promising activity in combination with Revlimid (lenalidomide) and dexamethasone (Decadron).

Data on side effects was not collected or reported as safety was not part of the analysis.

Tags: dexamethasone, multiple myeloma, steroids

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According to results of Eastern Cooperative Oncology Group Phase III clinical trial E4A03 for multiple myeloma, patients with multiple myeloma can experience dramatically improved results when they are administered with a combination of lenalidomide and low-dose dexamethasone therapy when compared to a combination of lenalidomide plus high-dose dexamethasone.

This finding was reported by S. Vincent Rajkumar, M.D. at the American Society of Hematology‘s annual meeting.

From News-Medical.Net:

The study compared combination treatment of oral medications lenalidomide (a novel chemotherapeutic agent) and either high- or low-dose dexamethasone (a potent steroid effective against myeloma) in 445 patients with newly diagnosed myeloma. Lenalidomide plus high-dose dexamethasone had an 18-month survival rate of 80 percent. The comparative therapy using low-dose dexamethasone showed a significantly higher 91 percent overall survival rate at 18 months, with much less toxicity.

“The lower survival rates with the high-dose dexamethasone can be attributed to disease progression as well as treatment-related toxicities,” says Dr. Rajkumar. “This is a major advance in the treatment of this cancer, and also gives researchers a new direction to explore — that more is not necessarily better.”

Dr. Rajkumar, Mayo Clinic Cancer Center hematologist and lead investigator of the study, noted that it is surprising to know that side effects are increased and survival rate is reduced when high doses of steroids are administered.

Tags: dexamethasone, lenalidomide, multiple myeloma, steroid, steroids

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Lenalidomide and Dexamethasone, two drugs when taken in a combination, can prove useful for providing significant relief to patients afflicted with multiple myeloma. This finding was disclosed by a study that was conducted at 44 centers in the United States and Canada and involved 353 patients with myeloma.

Progression of myeloma can be slowed down with the pairing of a new derivative of thalidomide with a steroid and this combination could prolong lives of patients who have relapsed from treatments in the past.

From News-Medical.Net:

“These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease,” Weber says. “We also owe a debt to the willing patients who participated in this study.”

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marrow may cause pain, and weaken bones predisposing them to fracture. In the United States about 20,000 people are diagnosed with multiple myeloma annually, and about 11,000 succumb to the disease each year.

Thalidomide, a breakthrough drug for multiple myeloma, is produced and marketed by Celgene Corporation as Thalomid(r). The company chemically altered thalidomide to make lenalidomide, known commercially as Revlimid(r), in hopes of reducing side effects and improving efficacy against the disease. The drugs attack both the malignant cells and the cellular environment that nurtures them.

Lead author Donna Weber, M.D., associate professor in the Department of Lymphoma and Myeloma at the University of Texas M. D. Anderson Cancer Center, remarked that this combination can do the trick particularly when the disease becomes immune to one therapy.

Tags: dexamethasone, lenalidomide, multiple myeloma, steroid

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Patients with multiple myeloma, a cancer of the plasma cells in the bone marrow, can experience significant relief and improved survival rate with steroid pills, as per researchers at the Cedars-Sinai Medical Center.

Multiple myeloma is a severe health complication that takes lives of nearly 14,000 people on a yearly basis in the United States alone.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

The use of prednisone in response to an upfront chemotherapy can be easily classified as a safe and effective treatment option for prolonging the lives of patients, according to James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center.

Tags: chemotherapy, multiple myeloma, Prednisone, steroid pills

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A combination of steroids, lenalidomide and dexamethasone, is effective against multiple myeloma that is considered to be one of the most dreaded forms of cancer. This finding was disclosed by a study involving 353 patients with myeloma that was conducted at 44 centers in the United States and Canada.

The study highlighted that pairing a new thalidomide derivative with a steroid could be more than useful for slowing down future progression of multiple myeloma.

From News-Medical.Net:

“These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease,” Weber says. “We also owe a debt to the willing patients who participated in this study.”

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marrow may cause pain, and weaken bones predisposing them to fracture. In the United States about 20,000 people are diagnosed with multiple myeloma annually, and about 11,000 succumb to the disease each year.

Thalidomide, a breakthrough drug for multiple myeloma, is produced and marketed by Celgene Corporation as Thalomid(r). The company chemically altered thalidomide to make lenalidomide, known commercially as Revlimid(r), in hopes of reducing side effects and improving efficacy against the disease. The drugs attack both the malignant cells and the cellular environment that nurtures them.

Lead author Donna Weber, M.D., Associate Professor in the Department of Lymphoma and Myeloma at the University of Texas M. D. Anderson Cancer Center, said that a combination of steroids can be useful for treating the disease, especially when the disease becomes resistant to one drug.

Tags: dexamethasone, multiple myeloma, steroid, steroids

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Treatment involving steroid pills could be an effective option to enhance survival rate of patients afflicted with multiple myeloma, which is a cancer of the plasma cells in the region of bone marrow.

James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center, remarked that use of Prednisone in response to an upfront chemotherapy could be believed as a safe option of treatment in order to prolong lives.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

This finding was disclosed by researchers at the Cedars-Sinai Medical Center.

Tags: chemotherapy, multiple myeloma, Prednisone, steroid, steroid pills

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During a study conducted at 44 centers in the United States and Canada and involving 353 patients with myeloma, it was found that a combination of drugs lenalidomide and dexamethasone could be useful for treating patients.

It was found during the study that pairing a new derivative of thalidomide with a steroid could slow down the progress of multiple myeloma along with prolonging lives of patients who have earlier relapsed from past treatments.

From News-Medical.Net:

“These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease,” Weber says. “We also owe a debt to the willing patients who participated in this study.”

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marrow may cause pain, and weaken bones predisposing them to fracture. In the United States about 20,000 people are diagnosed with multiple myeloma annually, and about 11,000 succumb to the disease each year.

Thalidomide, a breakthrough drug for multiple myeloma, is produced and marketed by Celgene Corporation as Thalomid(r). The company chemically altered thalidomide to make lenalidomide, known commercially as Revlimid(r), in hopes of reducing side effects and improving efficacy against the disease. The drugs attack both the malignant cells and the cellular environment that nurtures them.

It was remarked by lead author Donna Weber, M.D., associate professor in the Department of Lymphoma and Myeloma at the University of Texas M. D. Anderson Cancer Center that these combinational drugs are effective as the disease may become immune to one therapy.

Tags: dexamethasone, lenalidomide, multiple myeloma, myeloma, steroid, thalidomide

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Results of Eastern Cooperative Oncology Group Phase III clinical trial E4A03 for multiple myeloma show significantly improved overall survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone. This finding was reported by S. Vincent Rajkumar, M.D. at the American Society of Hematology’s annual meeting.

Presently, lenalidomide and high-dose dexamethasone, referred to as Rev/Dex, is prescribed as a second-line myeloma treatment.

From Sciencedaily.com:

“The standard treatment for myeloma usually includes high doses of steroids such as dexamethasone. In this study we were hoping to find that a lower dose of steroids would be just as effective,” says Dr. Rajkumar, Mayo Clinic Cancer Center hematologist and lead investigator of the study. “We were surprised to find that the regimen with high-dose steroids actually was decreasing survival, besides contributing to increased side effects.”

The study compared combination treatment of oral medications lenalidomide (a novel chemotherapeutic agent) and either high- or low-dose dexamethasone (a potent steroid effective against myeloma) in 445 patients with newly diagnosed myeloma. Lenalidomide plus high-dose dexamethasone had an 18-month survival rate of 80 percent. The comparative therapy using low-dose dexamethasone showed a significantly higher 91 percent overall survival rate at 18 months, with much less toxicity.

Dr. Rajkumar said that the finding is a major advance for treating cancer besides offering a new direction to the researchers to explore that more is not necessarily better.

Tags: dexamethasone, lenalidomide, multiple myeloma, steroids

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Treatment of multiple myeloma, a dreadful type of cancer, with steroid pills is an effective form of treatment for improving the overall survival rate of patients, as per researchers at the Cedars-Sinai Medical Center.

Multiple myeloma is a cancer of the plasma cells in the bone marrow that is believed to claim approximately 14,000 lives annually in the United States alone.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center, remarked that use of prednisone in response to an upfront chemotherapy can be classified as safe and effective for treating patients suffering from multiple myeloma.

Tags: cancer, chemotherapy, multiple myeloma, Prednisone, steroid, steroid pills

Posted in buy steroids, Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

Treatment based on steroid pills may prove to be an effective option for improving the overall survival rate of patients with multiple myeloma, a cancer of the plasma cells in the bone marrow.

This finding was disclosed by researchers at the Cedars-Sinai Medical Center.

The use of prednisone in response to an upfront chemotherapy can be considered as a safe treatment option to prolong the lives of multiple myeloma affected patients, as per James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

The involved researchers said that remissions can be better maintained and patients can live for long when oral prednisone is administered in long-term after chemotherapy treatment.

Tags: chemotherapy, multiple myeloma, oral prednisone, Prednisone, steroid, steroid pill treatment, steroid pills

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