The overall survival rate of patients suffering from a cancer of the plasma cells in the bone marrow, multiple myeloma, could be improved considerably with steroid pill treatment.

The use of Prednisone in response to an upfront chemotherapy can be easily described as a safe option to prolong lives of multiple myeloma patients, according to James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

Remission can be better controlled and prolonging lives become easy tasks when oral prednisone is administered in the long-term after chemotherapy treatment, as per the researchers.

Tags: chemotherapy, multiple myeloma, oral prednisone, Prednisone, steroid, steroid pill treatment, steroid pills

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Multiple myeloma can be effectively treated by using a combination of lenalidomide and dexamethasone, according to a study that involved 353 patients with myeloma and conducted at 44 centers in the United States and Canada.

It was revealed during the study that pairing a new thalidomide derivative with a steroid can slow down the progression of multiple myeloma besides prolonging the lives of patients who have relapsed from earlier treatments.

From News-Medical.Net:

“These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease,” Weber says. “We also owe a debt to the willing patients who participated in this study.”

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marrow may cause pain, and weaken bones predisposing them to fracture. In the United States about 20,000 people are diagnosed with multiple myeloma annually, and about 11,000 succumb to the disease each year.

Thalidomide, a breakthrough drug for multiple myeloma, is produced and marketed by Celgene Corporation as Thalomid(r). The company chemically altered thalidomide to make lenalidomide, known commercially as Revlimid(r), in hopes of reducing side effects and improving efficacy against the disease. The drugs attack both the malignant cells and the cellular environment that nurtures them.

Lead author Donna Weber, M.D., associate professor in the Department of Lymphoma and Myeloma at The University of Texas M. D. Anderson Cancer Center, said that the combination seems to be effective as the disease may become immune to one therapy.

Tags: dexamethasone, lenalidomide, multiple myeloma, myeloma, steroid, thalidomide

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Treatment methodology related with steroid pills can prove to be an effective option for improving survival rate of patients with multiple myeloma, a cancer of the plasma cells in the bone marrow. This finding was revealed by researchers at the Cedars-Sinai Medical Center.

James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center, said that using prednisone in response to an upfront chemotherapy may be considered as a safe option for prolonging life of patients of multiple myeloma, a cancer of the plasma cells in the bone marrow.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

The involved researchers remarked that maintenance of remission and prolonging of life years are facilitated when patients are administered with oral prednisone in the long-term after chemotherapy treatment.

Tags: chemotherapy, multiple myeloma, oral prednisone, Prednisone, steroid, steroid pill treatment, steroid pills

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Lisa Ray, an Indian-origin actress who had worked in many successful Bollywood and Hollywood movies, has recently been diagnosed with cancer. It was recently revealed by her in the blog (lisaraniray.wordpress.com) that she is suffering from multiple myeloma but expect to beat the ailment.

She said, “I was diagnosed with Multiple Myeloma on June 23rd. Started my first cycle of treatment July 2nd. Not long ago.”

Lisa also said that her skin is getting stretched when asked about steroids and life in the wetsuit.

From Lisaraniray.wordpress.com:

In the industry I’m in, you could say, its motive alone that gives character to your acting.

So today with Velcade and, Revlimid and other promising new treatments in the pipeline our survival rates are improving. But only with an ever expanding toolbox of treatments and awareness can this Cancer be beat. So I’m going to do everything I can to wrench the spotlight onto Myeloma and Cancer Awareness.

I believe it can be cured.

That’s the Dirty Realist in me.

So back to the ‘Yellow’ Diaries. And more on ‘Yellow’ and charging your yellow later…

On Steroids: you are HUNGRY ALL THE TIME.

When Dr. Ahmed Galal, my Warrior-Hematologist at Princess Margaret Hospital gave me my first cycle of meds, he capped his recommendation off with a charming gesture that meant: Beware of sweets.

Well. Sweet things aren’t the only temptation.

Every cycle of treatment, I’m on Dexamethasone for four days on, then four days off.

Ever since this news broke down, her fans have been praying for an early recovery so that they can see the most of this actress.

Tags: cancer, dexamethasone, multiple myeloma, steroids

Posted in buy steroids, Celebrities and Steroids, Steroid Cycles, Steroids and Anabolic Steroids

According to researchers at the Cedars-Sinai Medical Center, steroid pill treatment can be highly effective when it comes to improving the overall survival rate of patients with multiple myeloma, a cancer of the plasma cells in the bone marrow.

Multiple myeloma, which is considered to be a dreadful type of cancer, takes approximately 14,000 lives in the United States alone, each year.

James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple Myeloma and Bone Metastasis Program at Cedars-Sinai Medical Center, remarked that the use of prednisone in response to an upfront chemotherapy is a safe option for prolonging the lives of patients suffering from Multiple Myeloma.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

It was concluded by the involved researchers that patients administered with oral prednisone in the long-term after chemotherapy treatment were able to maintain their remission and lived longer.

Tags: chemotherapy, multiple myeloma, oral prednisone, Prednisone, steroid, steroid pill treatment, steroid pills

Posted in buy steroids, Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

Actress Lisa Ray, who has worked in many Indian and Hollywood movies, has been diagnosed with cancer. She recently revealed in her blog (lisaraniray.wordpress.com) that she is learning to face this disturbing fact and is quite hopeful of beating the ailment.

She says, “I was diagnosed with Multiple Myeloma on June 23rd. Started my first cycle of treatment July 2nd. Not long ago.”

When asked about her steroids and life in the wetsuit, Lisa remarked that she feels her skin getting stretched and move in ways that she has not felt before.

From Lisaraniray.wordpress.com:

In the industry I’m in, you could say, its motive alone that gives character to your acting.

So today with Velcade, Revlimid and other promising new treatments in the pipeline our survival rates are improving. But only with an ever expanding toolbox of treatments and awareness can this Cancer be beat. So I’m going to do everything I can to wrench the spotlight onto Myeloma and Cancer Awareness.

I believe it can be cured.

That’s the Dirty Realist in me.

So back to the ‘Yellow’ Diaries. And more on ‘Yellow’ and charging your yellow later…

On Steroids: you are HUNGRY ALL THE TIME.

When Dr. Ahmed Galal, my Warrior-Hematologist at Princess Margaret Hospital gave me my first cycle of meds, he capped his recommendation off with a charming gesture that meant: Beware of sweets.

Well. Sweet things aren’t the only temptation.

Every cycle of treatment, I’m on Dexamethasone for four days on, then four days off.

All her fans have been seen praying to the almighty for an early recovery for this actress of substance.

Tags: cancer, dexamethasone, multiple myeloma, steroids

Posted in buy steroids, Celebrities and Steroids, Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

The combination of lenalidomide and dexamethasone is effectual against multiple myeloma: this was a fact that was revealed after a study involving 353 patients with myeloma was conducted at 44 centers in the United States and Canada.

The study also found out that pairing a new thalidomide derivative with a steroid can considerably slowdown any further progression of multiple myeloma, which is an incurable bone marrow cancer. It was also revealed that this combination may also prove its worth to prolong lives of patients who have relapsed from previous treatments.

From News-Medical.Net:

“These trials highlight how large-scale cooperation in a team effort by myeloma investigators can quickly confirm benefits and introduce new active agents for patients with this disease,” Weber says. “We also owe a debt to the willing patients who participated in this study.”

Multiple myeloma is caused by formation of abnormal plasma cells, a type of white blood cell, in the bone marrow. These cells multiply rapidly, crowding out normal red and white blood cells and platelets. Tumors starting in the bone marrow may cause pain, and weaken bones predisposing them to fracture. In the United States about 20,000 people are diagnosed with multiple myeloma annually, and about 11,000 succumb to the disease each year.

Thalidomide, a breakthrough drug for multiple myeloma, is produced and marketed by Celgene Corporation as Thalomid(r). The company chemically altered thalidomide to make lenalidomide, known commercially as Revlimid(r), in hopes of reducing side effects and improving efficacy against the disease. The drugs attack both the malignant cells and the cellular environment that nurtures them.

It was remarked by lead author Donna Weber, M.D., Associate Professor in the Department of Lymphoma and Myeloma at The University of Texas M. D. Anderson Cancer Center that a combination of medical drugs may prove to be beneficial in ongoing treatment as a disease may become resistant to one drug.

Tags: bone marrow cancer, dexamethasone, lenalidomide, multiple myeloma, myeloma, steroid, thalidomide

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According to a team headed by Dana-Farber Cancer Institute investigators reported at the annual meeting of the American Society of Hematology, a new combo of Velcade with dexamethasone and lenalidomide can prove to be effective for patients who have been recently diagnosed with multiple myeloma.

The combination of these three drugs is effective for treating multiple myeloma patients who have relapsed after failing to respond to standard treatment therapies or after successful treatment.

From News-Medical.Net:

The three-pronged regimen of Velcade, lenalidomide (Revlimid) and dexamethasone – referred to as Rev/Vel/Dex – has achieved an overall response rate of 98 percent in 42 patients evaluated thus far in a Phase 1-2 trial, said Paul Richardson, MD, of Dana-Farber and the study’s principal investigator. He added that 52 percent of the patients had high quality responses (very good partial response or better), with 30 percent achieving complete response to date.

“These may be some of the best response rates we’ve seen to date with up-front therapies, and although these are preliminary results, they are extremely promising,” Richardson said. The patients were previously untreated when they received the Rev/Vel/Dex combination.

Velcade is a “smart” drug known as a proteasome inhibitor that blocks the myeloma cells’ waste disposal system, creating an accumulation of toxic compounds that poison the cell. Revlimid is a chemical relative of thalidomide that affects several pathways in cancer cells, including immune mechanisms and blood vessel growth to tumors. Dexamethasone is a steroid hormone that counters inflammation and is used to treat hematologic malignancies such as myeloma. Studies leading to the trial of the three drugs in combination were carried out at Dana-Farber.

The findings are expected to offer much-awaited relief to patients with multiple myeloma, who have been expecting an effective treatment methodology for the last many years.

Tags: dexamethasone, lenalidomide, multiple myeloma, myeloma, Revlimid, steroid, steroid hormone, Velcade

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Thalomid, which is also known as thalidomide, has been halted by drug company Celgene earlier than expected after the drug was shown to limit the progression of the blood cancer multiple myeloma.

It was revealed during the phase 3 trial of 270 patients that thalomid offers great benefits to patients who are suffering from blood cancer. These results prompted the decision that the trial patients not on this drug should also be given an opportunity to add thalomid to their treatment regimen.

From News-Medical.Net:

According to Celgene spokesman Brian Gill, Thalomid is currently the most widely prescribed drug for multiple myeloma.

It seems that while companies are not allowed to actively promote a drug for a condition for which it is not approved by regulators, doctors are allowed to prescribe it “off-label” for any disease.

Celgene is now chasing formal U.S. Food and Drug Administration approval for Thalomid to be used in multiple myeloma.

The FDA has however asked for updated safety information before allowing the drug to be marketed for treating newly diagnosed multiple myeloma.

Some of the side effects seen in the trial included insomnia, tremors and dizziness, and more than 10 percent of the Thalomid patients suffered deep vein thrombosis, compared with 1.7 percent of patients treated only with dexamethasone.

Pulmonary embolism occurred in 5.6 percent of Thalomid patients, compared with 1.7 percent of patients treated with dexamethasone alone.

Gill says the company is planning a wider commercial launch next year of both Thalomid and a successor drug, Revlimid, which was approved by the FDA in December for treating a group of blood disorders known as myelodysplastic syndromes.

Celgene has also recently sought approval from the FDA for Revlimid for the treatment of last-stage multiple myeloma.

Tags: blood cancer, dexamethasone, multiple myeloma, thalidomide, thalomid

Posted in Steroids and Anabolic Steroids

Researchers at Cedars-Sinai Medical Center report that treatment with a steroid pill improves the overall survival of patients with multiple myeloma, a cancer of the plasma cells in bone marrow. The study shows that patients who received oral prednisone over the long term following treatment with chemotherapy maintained their remission and survived longer.

From Bio-medicine:

In the study, the researchers compared patients with multiple myeloma receiving prednisone in pill-form following a response to treatment with one of two chemotherapy combinations: vincristine, doxorubicin and dexamethasone with prednisone or with or without quinine, which has been found to increase the effectiveness of chemotherapy. Treatment with either of the chemotherapy combinations was repeated every 21 days for at least six months or until patients achieved at least a 25 percent reduction in tumor size. After a 53-month follow-up period, the investigators found that there was no difference in either progression-free or overall survival between the patients receiving chemotherapy with or without quinine.

To determine whether prednisone alone was effective as maintenance therapy, patients who responded to treatment with up-front chemotherapy were randomly selected to receive either 10 (the amount that the body normally makes daily) or 50 mg of prednisone every other day until their disease progressed.

At the end of the study, the research team found that the long term use of prednisone delayed progression of the disease and kept patients alive longer. Furthermore, 50 mg of prednisone every other day was well tolerated, which means that patients remain active and have a much better quality of life for longer. However, further studies will be conducted to examine whether prednisone is effective to prolong remission for patients with other cancers such as leukemia or lymphoma. In addition, other drug combinations that include prednisone will be evaluated as maintenance therapy for patients with multiple myeloma.

Tags: multiple myeloma, Prednisone, steroid, steroid pills

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