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Tuesday 14, Sep 2010

  Overweight or obesity reduce response to steroids

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Overweight or obesity reduce response to steroidsBeing overweight or obese does not make asthma worse in patients with mild and moderate forms of the health complication, as per researchers from National Jewish Health. It was, however, noted by the researchers that it could minimize the response to medications.

Lead author E. Rand Sutherland, Associate Professor of Medicine at National Jewish Health said that the findings suggest that asthma improvement may not necessarily result from loss of weight.

Dr. Sutherland said the data suggest that obese and overweight people respond less well to asthma controller medications when compared to their leaner counterparts.

Tuesday 20, Apr 2010

  Liver protection from obesity-linked liver disease

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Liver protection from obesity-linked liver diseaseMore and more people are falling into the trap of obesity these days and the complication has slowly become a societal problem that needs to be solved. Liver disease, particularly non-alcoholic steatohepatitis or NASH, is just one of the many complications associated with obesity.

Since treatment options for NASH are limited, there is an unmet requirement for pharmacologic treatment of this liver disease.

The findings were published as part of a recent article in World Journal of Gastroenterology by Dr. Baski-Bey et al. to provide support in abolishing the occurrence of NASH in the population.

Monday 19, Apr 2010

  Recipients of kidney transplants can do away with steroids

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Recipients of kidney transplants can do away with steroidsKidney transplant recipients notice daily steroids becoming a big part of their anti-rejection medications. However, use of steroids in the long-term can have its side effects such as bone disease, slow growth rate, and obesity in pediatric patients as per a study.

Amer Rajab, M.D., Ph. D. and lead author of the study, remarked that the affected patients can do away with steroids and added that a significantly lower incidence of rejection can be achieved using steroid free maintenance.

These findings are expected to offer invaluable insights to medical practitioners and their patients all over the world in order to get benefited in the form of side-effect free recovery.

Wednesday 24, Mar 2010

  Novel findings on childhood obesity and early PCOS

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Novel findings on childhood obesity and early PCOSNovel findings on treatments for childhood obesity and early polycystic ovary syndrome (PCOS) in young girls were presented via five studies presented in press conference on kid’s health in New Orleans during ENDO 2004, the 86th Annual Meeting of The Endocrine Society.

The research also evaluated how much anabolic steroids and body-shaping drugs are used by the teenage community. It was revealed that non-athlete teens and boys are more likely to make use of anabolic steroids while high school girls use more of body-shaping and athletic-enhancing drugs (BSD).

Dr. Linn Goldberg and researchers at Oregon Health and Sciences University analyzed the results from 2,036 females, while in another study they looked at results from 4,100 students.

Friday 19, Mar 2010

  Obese people at higher risk of persistent or severe persistent asthma

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Obese people at higher risk of persistent or severe persistent asthmaObese people are at a higher risk of developing persistent or severe persistent asthma than their thinner counterparts, as per a study presented at the American Thoracic Society 2007 International Conference.

During a study involved 3,059 adults with asthma, it was noted that obese patients (BMI=30) were more likely to report having continuous symptoms, miss more days of work, make more ER visits, and make more use of inhaled steroids for asthma control.

Lead researcher Brian Taylor, M.D., of Emory Crawford Long Hospital in Atlanta, said that there has been little data on obesity and asthma severity in the past despite a number of studies on obesity and asthma prevalence.

Thursday 24, Dec 2009

  Adiponectin, the metabolic link between bone mineral density and obesity

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Adiponectin, the metabolic link between bone mineral density and obesityAdiponectin, a protein secreted from adipocytes, has been found to be the metabolic link that can explain, in part, about the positive relationship between obesity and both minimized susceptibility to fractures and bone mineral density, as per researchers at the University of Toronto, Faculty of Medicine, Toronto, Canada.

This study appeared in an issue of Experimental Biology and Medicine.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said that these intriguing results provide noteworthy insights into adiponectin secretion, from adipocytes, loss of bone mineral density, and resulting increased fractures.

Tuesday 15, Dec 2009

  Obesity can minimize response to medications

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Obesity can minimize response to medicationsAccording to a study by National Jewish Health researchers, being obese or overweight does not worsen asthma in patients with mild or moderate disease forms but it can minimize the response to medications.

Lead author E. Rand Sutherland, Associate Professor of Medicine at National Jewish Health, and lead author of the paper appearing in the June 2009 issue of the Journal of Allergy and Clinical Immunology, said that there is a possible link between asthma and obesity.

This study suggests that people with asthma must make efforts for ensuring that body weight stays normal as excess of body weight may mean a less responsive body to steroid medications.

Saturday 27, Jun 2009

  Alteration in Steroid Receptor Genes create Fat Burning Muscle

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Alteration in Steroid Receptor Genes create Fat Burning MuscleA single protein in a combination with a related protein can play a pivotal role in the complex journey of the body to obesity, as per Dr. Ronald M. Evans, a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory.

Evans further remarked that this study can provide the latest, specific approach to cure obesity related ailments such as atherosclerosis, hyperlipidemiama, and resistance to insulin.

Dr. Evans pointed out that PPARd (Peroxisome proliferator-activated receptor delta) which acts as a master regulator in controlling ability of the body cells to burn fat, can suppress artery’s inflammatory response with an aim to dramatically slowdown progression of the lesion. The study revealed that the PPARd drugs can prove to be effective in inhibiting atherosclerosis by limiting the level of inflammation besides enhancing physical performance.

Monday 01, Jun 2009

  Immunity Increased By Steroids

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Immunity Increased By SteroidsPamela Fraker, MSU Professor of Biochemistry and Molecular Biology and a lead scientist, said that the neuro-endocrine system plays a big role in the human immune system and body overweight.

A number of factors such as poor diet, certain steroids, chronic stress do affect the immune system of the body.

Researchers studied the relationship between metabolism, the immune system and the neuro-endocrine systems. The study showed that the leptin, which is the hormone secreted by fat cells, administered the effect of white blood cell production in the body, enhancing body’s immune function.

MSU scientists further demonstrated the effect of leptin on immune system by working on mice. This effect was genetically programmed to have non-functional leptin. One of the mice groups was genetically programmed under this study to have non-functional leptin receptors. It was seen that mice that were given leptin had witnessed double the number of B cells, a type of white blood cells produced in the bone marrow that fights infection by making antibodies.

Fraker and his team is further investigating on the fact that that the steroids may help even obese people to increase their immunity. The studies may be released soon and so do the effect of steroids on immune system.

Wednesday 27, May 2009

  Excess Steroids Can Cause Obesity

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Excess Steroids Can Cause ObesityMost people believe that gaining too much weight or becoming obese is just caused by excessive eating. But studies show that obesity can be a symptom of another disease. Gaining too much weight can also be acquired from medical conditions such as Hypothyroidism, Cushing’s syndrome and depression.

Hypothyroidism causes excess weight gain because it slows down body’s metabolism, while Cushing syndrome is caused by too much cortisol hormone in the body.

Aside from these medical conditions, obesity can also be acquired through the use of steroids, anti-depressant, hypertension drugs and anti-seizure medications. Some steroids can lead to accumulation of excessive fats and fluids in between muscle tissues because some steroids bind with aromatase enzyme and convert into estrogen.

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