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Friday 15, Jun 2012

  Omalizumab may spare asthma patients of complications

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Half of patients treated with omalizumab were able to stop taking potentially harmful steroids and most needed them less often, according to experts.

Asthma UK urged Health chiefs to consider providing the jabs to more people.

Dr Rob Niven, of the University Hospital of South Manchester, added: “People with severe asthma live in fear of the next potentially fatal attack. Any research that supports an option that reduces the additional side effect burden of steroids is encouraging.”

Thursday 29, Mar 2012

  Anadrol

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When it comes to promoting extensive muscle mass and body strength gains, Anadrol or Oxymetholone is one synthetic anabolic steroid that you can trust without any second thought. This is not just because this steroid is extremely potent and provides the strongest anabolic effects of all oral steroids, but also because it is easily and affordably online. The best part is that you can make an order for Anadrol with just a few clicks from the comfort of your home, using secured payment options.

Active ingredient of Anadrol is Oxymetholone and lactose, povideone, starch, and magnesium stearate are the inactive ingredients in Anadrol tablets. It has the anabolic/androgenic ratio of 320:45 and this DHT-derived compound is not a progestin or a compound with progestenic activity.  The chemical structure of Oxymetholone is 17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one and it has the molecular formula of C21H32O. It belongs to the family of Dihydrotestosterone (DHT) and can be detected over a period of six to eight weeks. It has a half life of approximately eight to nine hours and the anabolic/androgenic ratio of 320:45. The molecular weight of this anabolic steroid is 332.48 g/mol at the base.

Anadrol (also known as A50 and A-bombs) is available in different forms such as capsules, pills, and injections and can be purchased online, with or without a medical prescription.

Originally developed by Zoltan in 1960, Anadrol was primarily used for treating anemia and osteoporosis and stimulating muscle growth in underdeveloped or malnourished patients. It soon gained popularity as an effective drug for protecting joints under heavy loads or during intense workouts and improving the production and urinary secretion of EPO (erythropoietin).

Use of this Schedule III drug, for a period of six to eight weeks, is related to dramatic improvements in body strength, muscle definition, muscle function, muscle size, and appetite. The anabolic steroid is also associated with significant enhancements in terms of red blood cell count, aggression, ability to handle intense workouts, quick recovery after injuries, promoting performance and stamina gains, and nitrogen retention.

The recommended dose of Anadrol is 1-5 mg per day per kilogram of body weight and commonly stacked with Testosterone, Equipoise, and Deca Durabolin.

Saturday 28, Jan 2012

  Dianabol

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Dianabol is one of the most common oral steroids called Methandrostenolone. A derivative of testosterone, Dianabol is one of the most popular steroids and exhibits strong anabolic and moderate androgenic properties. Its easy usage and effectiveness is what makes this steroid widely accepted. Its chemical name is 17a-methyl-17b-hydroxy-1,4-androstadien-3-one 1-Dehydro-17 a methyltestosterone.

Dianabol, or D-bol as it is commonly addressed, is widely used because of its remarkable ability to build muscle strength in a relatively very short span of time. It also possesses a multifaceted approach in building the muscles without causing and loss of weight. The Methandrostenolone contained in Dianabol is its most active ingredient and acts in an ergogenic manner when orally administered.

Most common users of D-bol are athletes and particularly bodybuilders seeking maximum muscle mass within minimum time limits. Dianabol contains a powerful anabolic agent which upon entering the body, increases the synthesis of the proteins and also causes the retention of nitrogen in it. Increase in the levels of proteins helps in the balancing of nitrogen in the body which further aids in the development of adaptogenic properties in it. This allows the body to adapt according to increased workloads as well as fatigue.

Dianabol’s primary role is that it lets the acquired muscle protein in the body to stay. This anabolic drug is also known to show considerable growth in body insulin, a hormone produced in the liver. This creates a soothing effect in the body and users of this effective steroid are often seen talking about improved sleep, lower stress levels, better appetite and feeling of relaxation despite outside pressures. This is particularly the result of increased normalizing effect of Dianabol after the RNA synthesis during stress. However, in bodybuilders, it prevents the body from avoiding catabolic stress which helps them perform at a higher level and also recover fast after tedious training regime.

What makes D-bol so sought after is its ability to stimulate strength gain in the muscle in a very direct way. During phases of heavy physical and mental stress & irregular training and caloric retention, this anabolic steroid creates a temporary anabolic state which stops the breaking down of protein so that it releases amino acids in other muscles of the body, making them more intact and strong.

Despite being such a popular muscle-mass building steroid, Dianabol is not very often used in pre-contest cycles. This is particularly because it increasingly aromatizes to estrogen and causes high retention of fluid in the body. It is always advised to administer this anabolic drug in limited amount as high dosage over an extended period of time can strain the functioning of the liver. Some other apparent effects that might occur owing to heavy dosage such as 100mg per day are gynecomastia, acne, oily skin, testicular atrophy, deepening of the voice, hair loss, high blood pressure and loss of libido in some cases.

The dosage of Dianabol is variable. For men, it is advisable to start with 10mg per day which can be increased up to 25mg per day. Women wanting to take Dianabol with an intent to cut fat and gain muscle strength should start with 5mg per day and must not go beyond 10mg in a day.

The active life of this drug is about 3-5 hours. Since it is rapidly absorbed in the digestive juices in the stomach, it is best advised to take it with food and large amount of water to avoid abdominal cramps. The advanced testing systems nowadays can identify metabolites of Dianabol in the urine samples of the user, up to 4 weeks after the last dose is administered.

Being a popular drug, Dianabol is easily available. There are numerous sites on the internet which sell this steroid from where it can be ordered with or without a medical prescription. One should bear in mind that Dianabol is a highly potent drug and hence should be taken only under the supervision of a physician.

Tuesday 20, Dec 2011

  Lives of patients may be changed with new asthma drug

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Pressure is mounting on the NHS to widen the use of a “wonder” drug that could help hundreds of thousands of severe asthma sufferers.

Currently, most of the 250,000 UK patients who suffer from severe allergic asthma are prescribed powerful oral steroids.

They cause patients to gain significant amounts of weight and eventually develop diabetes, cataracts and glaucoma. About half go on to suffer from osteoporosis and other suffer from depression, anxiety and even growth retardation. That has to be worth reducing.”

Friday 11, Nov 2011

  Severe asthma drug may spare patients of complications

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Experts have recently disclosed that half of patients treated with omalizumab were able to stop taking potentially harmful steroids and most needed them less often.

Health chiefs were urged by Asthma UK to consider offering the jabs to more people.

Dr Rob Niven, of the University Hospital of South Manchester, added: “People with severe asthma live in fear of the next potentially fatal attack. Any research that supports an option that reduces the additional side effect burden of steroids is encouraging.”

Saturday 05, Nov 2011

  Vitamin D deficiency caused by oral steroids

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People on oral steroids are twice more likely to suffer from severe vitamin D deficiency than the general populace, according to a new research.

Doctors should get the vitamin D level of patients measured while prescribing steroids, as per Amy Skversky, assistant professor of pediatrics at Albert Einstein College of Medicine.

The study on 31,000 children and adults disclosed that physicians should monitor vitamin D levels more diligently in patients being treated with oral steroids.

Thursday 07, Oct 2010

  Progression of Ocular Myasthenia Gravis can be stopped by steroids

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Progression of Ocular Myasthenia Gravis can be stopped by steroidsSteroids may help patients with myasthenia gravis (MG) to avoid the progression that begins in the eye muscles.

This finding was suggested by results from a retrospective analysis presented at the 135th Annual Meeting of the American Neurological Association (ANA).

Dr. Zaman said that doctors make use of pyridostigmine or steroids, depending on their preferences, as there are no specific guidelines to recommend steroid use in the disease.

Thursday 19, Aug 2010

  Long term use of steroids effective in reducing risk of Lymphoma In Rheumatoid Arthritis

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Long term use of steroids effective in reducing risk of Lymphoma In Rheumatoid ArthritisAccording to data presented at EULAR 2007, the Annual European Congress of Rheumatology, in Barcelona, Spain, treatment with oral steroids for a period of two years or more can reduce the risk of rheumatoid arthritis (RA) related lymphoma.

It was disclosed that benefits of steroids were experienced regardless of when in the course of the disease the steroids were first administered.

Study author Dr Eva Baecklund of Uppsala University Hospital, Sweden said the data reveals a new aspect of steroid treatment.

Thursday 22, Jul 2010

  Oxidative stress research can be effective for treating rare health condition

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Oxidative stress research can be effective for treating rare health conditionResearchers at Queen Mary University London and the University of Leicester have announced a potential breakthrough to treat a rare, fatal medical complication that affects children and young people.

The preliminary data highlighting efficacy of the breakthrough was published as a letter in the New England Journal of Medicine and one patient has already been treated and experienced promising results as per scientists and clinicians from the two universities.

Idiopathic pulmonary haemosiderosis is a rare disease with an unknown cause, according to Jonathan Grigg, Professor of Paediatric Respiratory and Environmental Medicine at Queen Mary University London.

Wednesday 07, Jul 2010

  Potential oral drug for rheumatoid arthritis discovered

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Potential oral drug for rheumatoid arthritis discoveredCH-1504, considered by many as a potential oral drug for rheumatoid arthritis (RA), can motivate women to treat their condition earlier because it is less difficult than currently-available treatment options.

Chelsea Therapeutics, a pharmaceutical company specializing in treatment for rheumatoid arthritis and other immunological diseases, is currently on a developing spree to formulate an oral anti-inflammatory drug and conducting Phase I clinical trials in the UK with an aim to provide an amicable solution for this condition that is more prevalent in women and develops between ages of 35 and 50.

Dr. M. Gopal Nair, a professor and vice-chairman at the department of Biochemistry and Molecular Biology at the University of South Alabama, initially developed the CH-1504 therapy.

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