According to Lung disease experts at Johns Hopkins, physicians treating their patients afflicted with COPD (chronic obstructive pulmonary disease) need to observe extra caution while dealing with them.

It was remarked by lead author and pulmonologist M. Brad Drummond, M.D., M.H.S. that this finding has implications and serves a reminder to COPD patients so that they could take necessary preventive steps for avoiding pneumonia, which doubles their risk of death.

From News-Medical.Net:

Despite the increased pneumonia risk, the team found no clear evidence that the drug therapy also pushes up rates for other steroid-related problems, such as bone fractures, nor was there an increase in deaths.

Senior study investigator and critical care specialist Eddy Fan, M.D., says the results of the analysis should not alarm patients or cause them to stop taking their medications but should spur physicians to screen and monitor their patients to find the lowest possible steroid dose that works, especially in the elderly, people with immune system problems, and people who have had multiple bouts of pneumonia and for whom repeat bacterial infection might be a life-threatening complication.

“Inhaled corticosteroids are not of equal benefit to all, and what we are seeing is that the treatment may be more harmful and pose a greater risk of harm to some,” says Fan, an instructor at the Johns Hopkins University School of Medicine.

As many as 11 million Americans are afflicted with COPD every year and a big majority of this population belongs to the category of past or present-day smokers.

Tags: chronic obstructive pulmonary disease, COPD, corticosteroids, inhaled corticosteroids, pneumonia, steroid

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Patients with pneumonia could expect significant relief coming their way with steroids, even better than what could have been achieved with the use of antibiotics alone, as per a study by researchers from the UT Southwestern Medical Center.

Health of a patient with pneumonia can be restored back with a combination of steroids and antibiotics, according to the study.

From News-medical.net:

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

Unlike the anabolic steroids used to bulk up muscle, corticosteroids are often used to treat inflammation related to infectious diseases, such as bacterial meningitis. Used against other infectious diseases, however, steroid therapy has been shown to be ineffective or even harmful.

In a study available online and in a future issue of the Journal of Infectious Diseases, researchers at UT Southwestern show that mice infected with a type of severe bacterial pneumonia and subsequently treated with steroids and antibiotics recovered faster and had far less inflammation in their lungs than mice treated with antibiotics alone.

The combination can also be effective to provide relief to patients in midst of an asthma attack (M pneumoniae infection).

Clinical trials will soon be conducted to confirm the findings, as per Dr. Robert Hardy, Study’s Senior Author & Associate Professor of Internal Medicine and Pediatrics.

Tags: anabolic steroids, antibiotics, corticosteroids, pneumonia, steroids

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According to the World Health Organization (WHO), patients suffering from bird flu and being administered with the antiviral drug Tamiflu are better positioned to survive for long than those on steroids.

The WHO warned in a statement that therapy involving corticosteroids has been unable to prove its efficacy and the fact that long-term use or high-doses of corticosteroids can lead to severe health complications make them ineffective.

From Bio-Medicine.org:

Frederick Hayden of WHO’s global influenza program said some doctors, notably in Vietnam and Indonesia, had administered steroids to try to save quickly deteriorating bird flu patients. Eight of nine had died, he said, citing published research.

“A concern is some treatment is of unsubstantiated value and in some instances may be doing more harm than good,” he told Reuters.

The WHO reaffirmed that early treatment with Tamilflu, made by Swiss-based Roche and known generically as oseltamivir, was useful in reducing death from the H5N1 virus. Giving it to people with advanced symptoms was also “warranted”.

“Data presented gave strong support that early treatment makes a difference,” Hayden said, citing data from Egypt where 20 of 34 bird flu patients have survived to date.

“Unfortunately the problem is many patients are coming in late with shortness of breath and progressive symptoms that would indicate advanced viral pneumonia,” he said.

It was suggested that antibiotics should be prescribed only when there is a good reason to suspect the presence of a bacterial complication to pneumonia among the affected patients.

Tags: bird flu, corticosteroids, pneumonia, steroids, Tamiflu, Tamilflu

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Pneumonia patients have something as a relief now.

The combination of corticosteroids to the traditional antimicrobial therapy may be regarded as an effectual form of treatment for helping pneumonia patients recover faster than with antibiotics alone, as per scientists from the UT Southwestern Medical Center.

From Sciencedaily.com:

Although antimicrobials remain the primary therapy for M pneumoniae infection, there have been several reports in recent years about physicians adding steroids to the treatment regimen of patients with severe cases, Dr. Hardy said. The problem, he said, is that those were individual case reports.

“They never had a control group, so it was impossible to tell what impact the addition of steroids had on recovery,” he said.

The new findings not only suggest that giving antibiotics with steroids can help individuals with pneumonia get better faster, but also suggest a potentially more effective therapy for someone in the midst of an asthma attack due to M pneumoniae infection. Up to 20 percent of asthma attacks in children and adults have been shown to be triggered by this bacterium.

Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author, noted that antibiotics and steroids form a synergy together. While the antibiotics kill the bugs, steroids treat lung inflammation.

Tags: antibiotics, antimicrobial therapy, corticosteroids, pneumonia, steroids

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Patients suffering from pneumonia can expect quick recovery with steroids and antibiotics rather than depending upon antibiotics alone, as per scientists from the UT Southwestern Medical Center.

In a study available online, it was noted that mice infected with a type of severe bacterial pneumonia and treated with a combination of steroids and antibiotics recovered faster besides displaying reduction in the level of lung inflammation than mice treated with antibiotics alone.

From News-Medical.Net:

“Some people might think that if you give steroids, it would counteract the effect of the antibiotic,” said Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author. “But it turns out you need the antibiotic to kill the bug and the steroid to make the inflammation in the lung from the infection get better. The steroids don’t kill the bugs, but they do help restore health.”

Pneumonia is a lung infection typically characterized by breathing difficulties and spread by coughing and sneezing. Symptoms include headache, fever, chills, coughs, chest pain, sore throat and nausea. Pneumonia caused by the Mycoplasma pneumoniae bacterium is generally a less severe form of the disease that can occur in any age group. It accounts for 20 percent to 30 percent of all community-acquired pneumonia cases.

In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae-induced airway inflammation. The animals were then evaluated after one, three and six days of therapy.

“It turns out that the group that got both the antibiotic and the steroids did the best,” Dr. Hardy said. “The inflammation in their lungs got significantly better.”

The list of other UT Southwestern researchers involved in the study included Dr. Christine Salvatore, infectious-disease fellow in pediatrics; Dr. Chonnamet Techasaensiri, postdoctoral trainee in pediatrics; Dr. Asunción Mejías, assistant professor of pediatrics; Dr. Juan Torres, visiting senior researcher in pediatrics; Kathy Katz, senior research associate in pediatrics; and Dr. Ana Maria Gomez, assistant professor of pathology along with researchers from the University of Milan making contributions.

Tags: antibiotics, lung infection, pneumonia, steroids

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After an evidence was found suggesting that some of the presently-used anti-inflammatory medications increase the risk of pneumonia by a full third, Lung disease experts at Johns Hopkins made a call for caution while recommendations are made by doctors while prescribing inhaled corticosteroids to people with COPD (chronic obstructive pulmonary disease).

COPD is believed to affect more than 11 million Americans on a yearly basis and most of this affected population belongs to the category of present or former smokers.

From News-Medical.Net:

Despite the increased pneumonia risk, the team found no clear evidence that the drug therapy also pushes up rates for other steroid-related problems, such as bone fractures, nor was there an increase in deaths.

Senior study investigator and critical care specialist Eddy Fan, M.D., says the results of the analysis should not alarm patients or cause them to stop taking their medications but should spur physicians to screen and monitor their patients to find the lowest possible steroid dose that works, especially in the elderly, people with immune system problems, and people who have had multiple bouts of pneumonia and for whom repeat bacterial infection might be a life-threatening complication.

“Inhaled corticosteroids are not of equal benefit to all, and what we are seeing is that the treatment may be more harmful and pose a greater risk of harm to some,” says Fan, an instructor at the Johns Hopkins University School of Medicine.

Pulmonologist M. Brad Drummond, M.D., M.H.S., who led the study, remarked that findings of this study are expected to provide a reminder to patients with severe lung disease to plan and take steps for reducing the risk of pneumonia, which doubles their risk of dying.

Tags: chronic obstructive pulmonary disease, COPD, corticosteroids, inhaled corticosteroids, pneumonia

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A call for greater caution for prescribing inhaled corticosteroids to people with COPD (chronic obstructive pulmonary disease) was made by Lung disease experts at Johns Hopkins. The call was made after evidence suggested that some of the most widely-used anti-inflammatory medications may increase the risk of pneumonia by a full third.

It is considered that more than eleven million Americans are suffering from COPD and many of them belong to the former or current smokers’ category.

From News-Medical.Net:

Despite the increased pneumonia risk, the team found no clear evidence that the drug therapy also pushes up rates for other steroid-related problems, such as bone fractures, nor was there an increase in deaths.

Senior study investigator and critical care specialist Eddy Fan, M.D., says the results of the analysis should not alarm patients or cause them to stop taking their medications but should spur physicians to screen and monitor their patients to find the lowest possible steroid dose that works, especially in the elderly, people with immune system problems, and people who have had multiple bouts of pneumonia and for whom repeat bacterial infection might be a life-threatening complication.

“Inhaled corticosteroids are not of equal benefit to all, and what we are seeing is that the treatment may be more harmful and pose a greater risk of harm to some,” says Fan, an instructor at the Johns Hopkins University School of Medicine.

Lead author of this study, pulmonologist M. Brad Drummond, M.D., M.H.S., said that the latest finding is a reminder to the medical fraternity and patients with severe lung disease to plan and take steps to reduce the risk of catching pneumonia, which doubles their risk of dying.

Tags: chronic obstructive pulmonary disease, COPD, corticosteroids, inhaled corticosteroids, pneumonia

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Scientists from the UT Southwestern Medical Center have found that adding corticosteroids to the traditional antimicrobial therapy may help pneumonia patients more than with antibiotics alone. Corticosteroids are generally used for treating inflammation in concern with infectious diseases while anabolic steroids are used for bulking up muscle.

Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author, was of the view that there is no truth in the long held belief that steroids counteract the effect of the antibiotic.

From News-Medical.Net:

In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae-induced airway inflammation. The animals were then evaluated after one, three and six days of therapy.

“It turns out that the group that got both the antibiotic and the steroids did the best,” Dr. Hardy said. “The inflammation in their lungs got significantly better.”

Although antimicrobials remain the primary therapy for M pneumoniae infection, there have been several reports in recent years about physicians adding steroids to the treatment regimen of patients with severe cases, Dr. Hardy said. The problem, he said, is that those were individual case reports.

“They never had a control group, so it was impossible to tell what impact the addition of steroids had on recovery,” he said.

Other UT Southwestern researchers involved in the study besides Dr. Hardy were Dr. Christine Salvatore, infectious-disease fellow in pediatrics; Dr. Chonnamet Techasaensiri, postdoctoral trainee in pediatrics; Dr. Asunción Mejías, assistant professor of pediatrics; Dr. Juan Torres, visiting senior researcher in pediatrics; Kathy Katz, senior research associate in pediatrics; and Dr. Ana Maria Gomez, assistant professor of pathology, some researchers from the University of Milan also contributed to the study.

Tags: anabolic steroids, corticosteroids, pneumonia, steroids

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According to scientists at the UT Southwestern Medical Center, traditional therapy when combined with corticosteroids can prove effective for treating patients with pneumonia and the benefit is easily seen in terms of improved recovery time.

In a study available online and in a future issue of the Journal of Infectious Diseases, it was shown by the researchers that corticosteroids and antibiotics can prove their combined worth for treating cases of pneumonia.

From News-Medical.Net:

In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae-induced airway inflammation. The animals were then evaluated after one, three and six days of therapy.

“It turns out that the group that got both the antibiotic and the steroids did the best,” Dr. Hardy said. “The inflammation in their lungs got significantly better.”

Although antimicrobials remain the primary therapy for M pneumoniae infection, there have been several reports in recent years about physicians adding steroids to the treatment regimen of patients with severe cases, Dr. Hardy said. The problem, he said, is that those were individual case reports.

Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author, was of the view that there is no truth in the myth that steroids can counteract the effect of the antibiotic as while antibiotics kill the bug, steroids improve lung inflammation and help in restoring health.

Tags: antibiotics, corticosteroids, pneumonia, steroid, steroids

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As per new results from the ARDS Clinical Research Network of the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, corticosteroids do not improve survival rate in patients suffering from last-stage ARDS (acute respiratory distress syndrome).

ARDS is a sudden and life-threatening lung condition affecting more than 150,000 people yearly in the United States alone and tend to develop in patients suffering from diseases such as pneumonia or sepsis or major injuries resulting in breathing failure.

From News-Medical.Net:

There is no specific drug treatment for ARDS. The focus of care is to get enough oxygen into the blood until the lungs are functioning again. Patients are placed in the intensive care unit and supported with mechanical ventilators and fluids. Some patients recover and can breathe on their own within a week or so. Others might need to be on mechanical support to help with breathing for longer periods of time, but they can develop long-term complications from ventilator use or other treatments.

Because ARDS is related to inflammation in the lung, steroids are sometimes used in the hopes of helping the lungs heal. Earlier small or observational studies have suggested that moderate doses of steroids given 7 or more days after the onset of ARDS might improve lung function and increase survival. But a larger randomized clinical trial – considered the gold standard in medical research – was needed to determine whether moderate doses of steroids are beneficial for patients with late-stage ARDS.

Some early benefits to steroid treatment were noted by the involved researchers and these benefits appeared to minimize inflammation in the lungs. In addition to that, the use of steroids does not lead to more secondary infections – a common side effect of steroids.

Tags: acute respiratory distress syndrome, ARDS, corticosteroids, pneumonia, steroids

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