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Thursday 12, Jun 2014

  Athletes Abuse Non-Approved Therapeutic Compounds For Performance Gains

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Athletes Abuse Non-Approved Therapeutic Compounds For Performance Gains

Non-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) are commonly being sold on the black market because of their performance enhancing qualities. This finding was revealed by researchers from the German Sport University Cologne in Germany in a study appearing in an issue of Drug Testing and Analysis published by Wiley-Blackwell.

In a product sold via the internet, the availability of authentic Selective Androgen Receptor Modulators was demonstrated for the first time by the detection of the drug candidate Andarine. SARMs represent a class of therapeutics that are used for treating health conditions like osteoporosis, benign prostatic hyperplasia (BPH), sarcopenia, and cancer cachexia. However, none of the agents are approved for therapeutic use though SARMs are gaining widespread popularity in the sport doping communities as it is believed that they offer the advantages of traditional anabolic androgenic steroids like Testosterone with fewer unwanted side effects.

The World Anti-Doping Agency (WADA) prohibited the use of SARMs in sports in 2008 because of their potential for misuse. The World Anti-Doping Agency is in constant touch with drug evaluation bodies, medicine agencies, and pharmaceutical and biotechnological companies on the issues of therapeutics being misused in sports. The preventive approach of WADA was validated with the finding of non-approved arylpropionamide-derived SARM termed Andarine that was commercially available. Declared as green tea extracts and face moisturizer to pass customs, this product was available on the internet for a low price.

Mario Thevis, Ph.D., and colleagues, analyzed the advertised product using state-of-the-art mass spectrometric approaches with high resolution/high accuracy (tandem) mass spectrometry for proving that SARMs lacking clinical approval are distributed and potentially misused in sports. Dr. Thevis said one unit (30 mL) was purchased online and delivered in a box labeled to contain face moisturizer and green tea extract and the sealed bottle did not declare any content and no further documents accompanied package.

Dr. Thevis explained that LC-MS (/MS) analysis of this solution disclosed the presence of S-4 at approximately 150 mg/mL with equal amounts in each container, yielding a total of 4.5 g of the Selective Androgen Receptor Modulator. The active ingredient was identified and characterized by comparison to synthesized reference material regarding retention time and production mass spectrum, its elemental composition (via high resolution/high accuracy mass spectrometry), and elucidation of its mass spectrometric behavior. It was also noted that a considerable amount of byproduct was observed besides the detection of the active ingredient S-4. Dr. Thevis said major concerns result from these findings and added that this product with considerable anabolic properties is readily available without sufficient research on its undesirable effects and this is especially significant where uncontrolled dosing is applied and drug impurities with unknown effects are present in considerable amounts as observed in the studied material. Dr. Thevis concluded our study demonstrates once more that the misuse of therapeutics without clinical approval by athletes cannot be dismissed.

The issue was addressed at the Conference of Parties to the International Convention against Doping in Sport, at the United Nations Educational, Scientific and Cultural Organization’s (UNESCO) headquarters in Paris.

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Wednesday 26, May 2010

  SARMs emerging as doping products in sports

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SARMs emerging as doping products in sportsNon-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) are being sold for their performance enhancing qualities on the black market, as per researchers from the German Sport University Cologne in Germany.

This availability of authentic SARMs was recently highlighted after detecting Anadrine in a product sold on the Internet and is getting popular as SARMs provide advantages of traditional anabolic/androgenic steroids such as testosterone with fewer unwanted side effects.

Mario Thevis, Ph.D., said that the study highlighted that the misuse of therapeutics without clinical approval cannot be overruled.

Wednesday 10, Feb 2010

  SARM sale on high for enhancing performance

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sarm-sale-on-high-for-enhancing-performanceThe sale of non-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) is on an all-time high in the Internet black market. According to researchers from the German Sport University Cologne in Germany, this demand hike is due to the performance enhancing features of these SARMs.

The researchers were able to identify one drug that was sold on the Internet that included Andarine suggesting that anabolic agents are readily and affordably sold on the online black market.

The study findings were presented in an issue of Drug Testing and Analysis published by Wiley-Blackwell.

John Fahey, WADA President, said that strict laws need to be adopted by government agencies for preventing distribution and sale of steroids in sporting events.

Thursday 17, Dec 2009

  New sports doping products sold on the Black Market

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New sports doping products sold on the Black MarketNon-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) are being openly sold on the black market because of their performance enhancing characteristics, according to researchers from the German Sport University Cologne in Germany.

This finding emerged after detection of the drug candidate Andarine in a product sold via the Internet that highlighted that the availability of authentic SARMs.

Mario Thevis, Ph.D., and colleagues, said that SARMs that come with considerable anabolic properties are readily available without sufficient research on their undesirable effects. This issue was recently addressed at the Conference of Parties to the International Convention against Doping in Sport, held October 26-28, 2009 at the United Nations Educational, Scientific and Cultural Organization’s (UNESCO) headquarters in Paris.

Tuesday 01, Dec 2009

  Non-steroidal and tissue-selective anabolic agents sold for performance enhancing effects

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Non-steroidal and tissue-selective anabolic agents sold for performance enhancing effects  Non-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) are being sold on the Internet black market because of their performance enhancing characteristics, as per researchers from the German Sport University Cologne in Germany. It was revealed that one of the drugs sold on the Internet had the drug candidate Andarine, which suggests that anabolic agents are being sold freely on the web.

Complete findings of the study appeared in the latest issue of Drug Testing and Analysis published by Wiley-Blackwell.

John Fahey, WADA President, remarked that government agencies are required to adopt necessary laws and regulations for combating trafficking and sale of illegal substances to inhibit steroids in sporting events.

Monday 19, Jan 2009

  SARMs— THE NEW STEROIDS

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sarms-steroidsIt seems like every athlete and bodybuilder knows the advantages and the disadvantages of taking anabolic steroids to boost their performances during games and to make their training more efficient. There’s a class of drugs out there that have similar effects to steroids without the common problems of taking steroids that they don’t know about yet though– Selective Androgen Receptor Modulators or SARMs.

While the research on SARMs is still ongoing, studies have already been shown that it is a good alternative for hormone replacement therapy, and treatments for osteoporosis, benign prostate hypertrophy and muscle wasting diseases. All these conditions have also been the main reasons on why several steroids have been developed at one point or another. It won’t be long when SARMs will be sold online and in local gyms assuming it will continue to follow the footsteps of other performance enhancing drugs.

For now, the World Anti-Doping Agency has already banned the use of SARMs knowing that it will lead to a widespread abuse by athletes. Unfortunately, protocols and plans to detect SARMs use are still just on paper. The World Anti-Doping Agency is rushing to find a way to test for this drug because rumor has it that the top athletes have already been starting its use.