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Tuesday 26, Oct 2010

  Low dose contraceptive pill controls severe premenstrual disorder

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Low dose contraceptive pill controls severe premenstrual disorderAccording to a recently concluded study, low doses of oral contraceptive demonstrate as much efficacy as the present-day standard treatment for premenstrual syndrome, premenstrual dysphoric disorder (PMDD).

Kimberly Yonkers, M.D., associate professor in the departments of Psychiatry and Epidemiology and Public Health and lead author of the study remarked that PMDD patients often experience cyclical mood, behavioral, and physical symptoms that are triggered possibly by changes in steroid hormone levels.

Yale School of Medicine researchers said that a low dose oral contraceptive with a unique progestin and dosing regimen shows efficacy to treat PMDD along with suppression of the ovarian activity.

Wednesday 06, Oct 2010

  Bangladeshi sex workers face new danger

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Bangladeshi sex workers face new danger  Sex workers from Bangladesh at Faridpur brothel are chhukri, or bonded sex workers, sold by their families to a woman in return for two or three years in which the brothel-owner can pocket all their earnings are being forced to take Oradexon in order to look fairer.

The drug, Oradexon, is identical to one used for fattening cattle and is now a common thing with brothels throughout Bangladesh and young girls taking the pill face severe complications while making use of steroids to ‘plump up’ for clients

Some women in the ‘red light area’ think that use of Oradexon makes them look good and they do not find any troubles but the problem is that indiscriminate or long-term use of Oradexon can lead to obesity and other health complications. The dangers of Oradexon are all before Bangladeshi sex workers and there just don’t seem to any respite.

Monday 04, Oct 2010

  Severe premenstrual disorder controlled by contraceptive pills

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Severe premenstrual disorder controlled by contraceptive pillsA low dose of oral contraceptive is as effective as the treatment for the most severe form of premenstrual syndrome, premenstrual dysphoric disorder (PMDD), as per a study.

Individuals afflicted with this complication often face quite debilitating disorder experience cyclical mood, behavioral and physical symptoms. Changes in steroid hormone levels appear to be a trigger for symptoms to appear, according to Kimberly Yonkers, M.D., associate professor in the departments of Psychiatry and Epidemiology and Public Health, and lead author of the study.

From News-medical.net:

In this multi-center, double-blind, randomized clinical trial, 450 women ages 18 to 40, from 64 medical centers across the country with symptoms of PMDD, were given either the oral contraceptive or a placebo.

It was found that the women who were given the oral contraceptive had significantly greater improvement, over 48 percent compared to 36 percent, of women on the placebo.

They experienced greater enjoyment of hobbies, social activities, and interpersonal relationships, and greater symptom reduction.

It seems that forty-four women from both groups withdrew from the study due to adverse effects such as nausea and intermenstrual bleeding.

The low dose oral contraceptive contained drospirenone, a new progestin, and ethinyl estradiol.

In the study it was taken for 24 days followed by four days of inactive pills, which differs from traditional courses of therapy which have seven days of inactive pills.

Researchers at Yale School of Medicine remarked that a low dose oral contraceptive with a unique progestin and dosing regimen is effective for the treatment of PMDD besides suppressing ovarian activity.

Sunday 03, Oct 2010

  Sigma’s portfolio has anti-anxiety medication and steroid hormone replacements

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Sigma's portfolio has anti-anxiety medication and steroid hormone replacementsSIGMA Pharmaceuticals said that it had agreed to purchase a portfolio of drug brands and a plant from Bristol-Myers Squibb for $60 million cash, and will be raising $297m to fund the acquisition and pay down debt.

Sigma has grown significantly by adding new generic drugs to its product suite that has coincided with an improving preference for lower-cost generic drugs by consumers.

Other drugs included in the portfolio are hypertensive treatments, anti-anxiety medication, steroid hormone replacements, and anti-fungal agents.

Saturday 27, Feb 2010

  Protein modifier SUMO helps in differentiating between males and females

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Protein modifier SUMO helps in differentiating between males and femalesWalter Wahli and colleagues at the University of Lausanne, Switzerland, have been able to identify a new mechanism that underlies the differential expression of proteins in male and female mice.

The difference is in relation to expression of liver proteins controlling a large number of whole-body processes such as energy generation and steroid hormone production.

The research appeared in the Sept. 1, 2009 issue of the Journal of Clinical Investigation.

Monday 08, Feb 2010

  Levels of hormones affect financial traders’ performance

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levels-of-hormones-affect-financial-traders-performanceHigh morning levels of testosterone can help city traders to make more than just average profits, as per a research conducted at the University of Cambridge.

The involved scientists hypothesized that the improvement in terms of performance can be attributed to the fact that testosterone is known for increasing the appetite for risk and confidence – two factors that are good enough for augmenting the performance of a trader.

The study noted that naturally produced steroids in the body, especially cortisol and testosterone, can have a positive influence when it comes to finding as to how and why people caught in crashes often find it tedious to make a rational decision.

Tuesday 08, Dec 2009

  Toxic chemicals influence steroid hormones differently in humans and invertebrates

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Toxic chemicals influence steroid hormones differently in humans and invertebratesA team of French and American scientists, including Michael E. Baker, PhD, professor in UC San Diego’s Department of Medicine, Division of Nephrology-Hypertension, have found that enzymes used for steroid synthesis in snails, corals, octopuses, and insects are unrelated to those used in human beings.

The research was led by a team at the Université de Lyon, ENS Lyon and offered invaluable insight on evolution of steroid hormone signaling along with relationship of steroid synthesis to enzymes capable of detoxifying chemicals in the environment.

It is considered that the results of this study would have critical consequences for future studies on effect of toxic chemicals in living beings.


Monday 09, Nov 2009

  Performance of financial traders affected by hormone levels

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Performance of financial traders affected by hormone levelsAccording to a new research conducted at the University of Cambridge, City traders are likely to make more than average profits when they have high morning testosterone levels.

It was hypothesized by the involved scientists that this improved performance may be because of the fact that testosterone is known to increase appetite for risk and confidence – two qualities that can easily augment the performance of any trader.

Testosterone is a steroid hormone that controls competitive encounters and sexual behavior.

It was concluded that the influence of naturally produced steroids in the body, especially cortisol and testosterone, can provide insights into how and why people caught in crashes often find it tedious to make a rational decision.

 

 

 

Monday 19, Oct 2009

  Steroid Hormones get affected differently in Humans and Invertebrates

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Steroid Hormones get affected differently in Humans and InvertebratesAccording to a team of American and French scientists, including Michael E. Baker, PhD, professor in UC San Diego’s Department of Medicine, Division of Nephrology-Hypertension, enzymes that are used for steroid synthesis in snails, insects, corals, and octopuses are not related to those used in human beings.

This finding is expected to provide a new insight for studies on the effects of chemicals on response of steroids in humans.

In short, the research was successful in concluding that the method through which toxic chemicals effect the steroid hormone signaling of corals, snails, insects, and other invertebrates cannot be extrapolated to human ailments.

Tuesday 18, Aug 2009

  Combination of dexamethasone, Velcade, and lenalidomide effective for multiple myeloma

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Combination of dexamethasone, Velcade, and lenalidomide effective for multiple myelomaAccording to a team headed by Dana-Farber Cancer Institute investigators reported at the annual meeting of the American Society of Hematology, a new combo of Velcade with dexamethasone and lenalidomide can prove to be effective for patients who have been recently diagnosed with multiple myeloma.

The combination of these three drugs is effective for treating multiple myeloma patients who have relapsed after failing to respond to standard treatment therapies or after successful treatment.

From News-Medical.Net:

The three-pronged regimen of Velcade, lenalidomide (Revlimid) and dexamethasone – referred to as Rev/Vel/Dex – has achieved an overall response rate of 98 percent in 42 patients evaluated thus far in a Phase 1-2 trial, said Paul Richardson, MD, of Dana-Farber and the study’s principal investigator. He added that 52 percent of the patients had high quality responses (very good partial response or better), with 30 percent achieving complete response to date.

“These may be some of the best response rates we’ve seen to date with up-front therapies, and although these are preliminary results, they are extremely promising,” Richardson said. The patients were previously untreated when they received the Rev/Vel/Dex combination.

Velcade is a “smart” drug known as a proteasome inhibitor that blocks the myeloma cells’ waste disposal system, creating an accumulation of toxic compounds that poison the cell. Revlimid is a chemical relative of thalidomide that affects several pathways in cancer cells, including immune mechanisms and blood vessel growth to tumors. Dexamethasone is a steroid hormone that counters inflammation and is used to treat hematologic malignancies such as myeloma. Studies leading to the trial of the three drugs in combination were carried out at Dana-Farber.

The findings are expected to offer much-awaited relief to patients with multiple myeloma, who have been expecting an effective treatment methodology for the last many years.

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