According to a study by researchers from the UT Southwestern Medical Center, steroids can easily facilitate the recovery process for patients affected by pneumonia and even better than use of antibiotics alone.

It was suggested by the study that health of an affected patients can be restored back when steroids and antibiotics are combined.

From News-medical.net:

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

Unlike the anabolic steroids used to bulk up muscle, corticosteroids are often used to treat inflammation related to infectious diseases, such as bacterial meningitis. Used against other infectious diseases, however, steroid therapy has been shown to be ineffective or even harmful.

In a study available online and in a future issue of the Journal of Infectious Diseases, researchers at UT Southwestern show that mice infected with a type of severe bacterial pneumonia and subsequently treated with steroids and antibiotics recovered faster and had far less inflammation in their lungs than mice treated with antibiotics alone.

Dr. Robert Hardy, Study’s Senior Author & Associate Professor of Internal Medicine and Pediatrics, said that clinic trial would soon be performed for confirm the finding. It is worth noting that a combination of steroids and antibiotics can provide relief to a patient in the midst of an asthma attack (M pneumoniae infection).

Tags: anabolic steroids, corticosteroids, steroid therapy, steroids, traditional antimicrobial therapy

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Children who suffer from chicken pox and administered with steroids run an increased risk of a more severe case of the virus leading to death.

This finding was disclosed by pediatric oncologists at the Brenner Children’s Hospital, part of Wake Forest University Baptist Medical Center.

From News-Medical.Net:

“Steroids are used to treat leukemia and they suppress the immune system,” said Thomas McLean, a pediatric oncologist at Brenner Children’s Hospital. “When a child is exposed to the varicella virus (the virus that causes chicken pox) around the time they are receiving steroid treatment, they are more likely to contract a more severe case of chicken pox.”

McLean and his colleagues studied 697 patients with acute leukemia over a nine-year period. About 16 percent or 110 patients contracted chicken pox. Of those 110 patients, 54 had severe disease, including two deaths. Of the patients whose chicken pox was diagnosed within three weeks of taking steroids, 70 percent had severe infection whereas only 44 percent of those who had not received steroid therapy within three weeks had severe infection. Although the study was limited to patients with leukemia, the findings may apply to other conditions for which steroids are used, McLean said.

“One of the things we need to remember to ask before we prescribe steroid treatment is whether the child has had a recent exposure to chicken pox,” McLean said. “If so, we recommend waiting until the incubation period has passed before beginning steroid therapy.”

Chicken Pox, though mild in its nature, may turn fatal in acute cases. Prior to the discovery of varicella vaccine, around 12,000 people used to die from chicken pox on a yearly basis.

Tags: chicken pox, steroid, steroid therapy, steroid treatment, steroids, varicella vaccine, varicella virus

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Osiris Therapeutics, Inc. has announced the preliminary results for two phase III trials evaluating Prochymal for the treatment of acute graft versus host disease (GvHD).

Graft-versus-host disease is considered to be one of the most dreadful health complications of bone marrow transplantation. It is a fatal complication with no approved treatment option till date.

From News-Medical.Net:

Protocol 265 was designed to evaluate Prochymal as a first-line agent for the treatment of acute GvHD in combination with steroid therapy. The majority of patients in this trial were suffering from skin GvHD, which responded significantly better to steroids than had been previously reported in controlled trials. This high response rate to standard of care diminished the potential for Prochymal to demonstrate an effect.

In the more severe, steroid-refractory GvHD setting (protocol 280), the benefit of adding Prochymal to second-line therapy was evaluated. Prochymal approached statistical significance for the primary endpoint in the per-protocol patient population which is the group of patients that met all of the study protocol requirements, such as inclusion and exclusion criteria. Additionally, Prochymal significantly improved response rates to liver and gastrointestinal GvHD, for which there is currently no known reliable therapy. Notably, the Prochymal cohort had more severe GvHD (27% of Prochymal patients had grade D GvHD, the most severe form, vs. 16% of placebo patients.

It was remarked by C. Randal Mills, Ph.D., President and Chief Executive Officer of Osiris Therapeutics that more analysis is suggested for gaining appreciation of the rigorous, double-blind, placebo-controlled trial results.

Tags: acute graft versus host disease, bone marrow transplantation, GvHD, Prochymal, steroid, steroid therapy

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Patients suffering from pneumonia can expect significant relief in a short span of time for long term with steroids, as per a study by researchers from the UT Southwestern Medical Center.

It was suggested by the study that health of a pneumonia patient can be restored when steroids are used in a combination with antibiotics as compared to the use of antibiotics alone.

It was also noted that while steroids are effective for treating lung inflammation, antibiotics are effective for killing the bug.

From News-medical.net:

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

Unlike the anabolic steroids used to bulk up muscle, corticosteroids are often used to treat inflammation related to infectious diseases, such as bacterial meningitis. Used against other infectious diseases, however, steroid therapy has been shown to be ineffective or even harmful.

In a study available online and in a future issue of the Journal of Infectious Diseases, researchers at UT Southwestern show that mice infected with a type of severe bacterial pneumonia and subsequently treated with steroids and antibiotics recovered faster and had far less inflammation in their lungs than mice treated with antibiotics alone.

Dr. Robert Hardy, Study’s Senior Author & Associate Professor of Internal Medicine and Pediatrics, led the study and noted that studies in future would happen for confirming these findings.

Tags: anabolic steroids, corticosteroids, steroid therapy, steroids, traditional antimicrobial therapy

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Black teens suffering from asthma are more resistant to steroid treatment than their white counterparts, as per a research conducted at the National Jewish Medical and Research Center. It was suggested by the study that inhaled steroids may prove to be one of the best ways for asthma control management in an effective manner.

Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish, remarked that African-American children are more prone to be resistant to asthma steroid therapy than white children.

This study was published in the Journal of Allergy and Clinical Immunology.

From News.Bio-Medicine.Org:

“Our results suggest that children with steroid-resistant asthma are more likely to be African-American, to have required treatment with oral steroids at an earlier age and to require larger amounts of oral steroids for only marginal control of their asthma,” said Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

Other recent epidemiological studies have shown that blacks with asthma are sicker and have a higher mortality rate than whites with asthma. Doctors at National Jewish now are trying to determine whether blacks have a more vigorous immune response to airway inflammation–which means that higher doses of steroids must be used to control inflammation–or a poor response to steroids secondary to a genetic resistance to the drugs.

“The theory is that with ongoing airway inflammation you get worsening asthma and diminished steroid sensitivity,” Dr. Spahn said.

This study of 164 teen-agers treated at National Jewish also showed that 25 percent of the group was steroid resistant. Children with less than a 15 percent improvement in lung function following a “burst” of inhaled steroids–high doses over seven days–were considered steroid resistant.

“Twenty-five percent of the kids admitted to National Jewish have steroid-resistant asthma, which is much greater than anyone thought,” Dr. Spahn said.

It is believed that future studies are in the pipeline for determining if the black teens also have a more vigorous immune response to airway inflammation.

Tags: airway inflammation, steroid resistant, steroid therapy, steroid-resistant asthma

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Children suffering from asthma and being administered with steroids in the younger age but discontinuing the same after some time may not benefit from the same results, as per results from a comprehensive childhood asthma study.

This study finding came from the Childhood Asthma Management Program (CAMP) clinical trial that involved treatment of more than 1,000 children with mild-to-moderate asthma. Children were divided into three groups. While one received twice-daily budesonide and an inhaled corticosteroid, the second group received nedocromil (an inhaled non-steroid medication), and the third received placebo. All these groups also received albuterol, a bronchodilator, and oral corticosteroids for treating asthma symptoms.

From News-Medical.Net:

Inhaled corticosteroids such as budesonide have been shown to be the most effective form of anti-inflammatory treatment for asthma by controlling symptoms and improving pulmonary function. Results from the original CAMP trial showed that using budesonide twice daily led to fewer hospitalizations and urgent care visits, fewer days in which additional asthma medications were needed and a reduced need for albuterol, a fast-acting drug for relief of acute asthma symptoms. Using nedocromil twice daily reduced urgent care visits and courses of oral steroids for severe symptoms, but did not affect the number of hospitalizations, symptoms or airway responsiveness.

Although the patients had fewer symptoms five years after stopping the daily medication, Strunk cautions that doesn’t mean that they can stop using asthma medications altogether or that their asthma is cured.

The findings of this study are expected to offer new insights to members of the medical fraternity when it comes to formulation of new asthma treatment plans.

Tags: albuterol, Asthma, budesonide, corticosteroids, nedocromil, non-steroid, steroid, Steroid drugs, steroid therapy

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Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish, has remarked that black asthmatic teens are more resistant to steroid treatment for curing asthma than the white teens. The study was published in the Journal of Allergy and Clinical Immunology.

It is important to note here that many recent epidemiological studies have suggested that the black teens run a higher risk of being sick and suffer from a greater mortality rate than the white teens.

From News.Bio-Medicine.Org:

“Our results suggest that children with steroid-resistant asthma are more likely to be African-American, to have required treatment with oral steroids at an earlier age and to require larger amounts of oral steroids for only marginal control of their asthma,” said Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

Other recent epidemiological studies have shown that blacks with asthma are sicker and have a higher mortality rate than whites with asthma. Doctors at National Jewish now are trying to determine whether blacks have a more vigorous immune response to airway inflammation–which means that higher doses of steroids must be used to control inflammation–or a poor response to steroids secondary to a genetic resistance to the drugs.

“The theory is that with ongoing airway inflammation you get worsening asthma and diminished steroid sensitivity,” Dr. Spahn said.

This study of 164 teen-agers treated at National Jewish also showed that 25 percent of the group was steroid resistant. Children with less than a 15 percent improvement in lung function following a “burst” of inhaled steroids–high doses over seven days–were considered steroid resistant.

“Twenty-five percent of the kids admitted to National Jewish have steroid-resistant asthma, which is much greater than anyone thought,” Dr. Spahn said.

It was remarked by the involved researchers that further studies are required to ascertain if the black teens also run a higher risk of a more vigorous immune response to airway inflammation or not.

Tags: airway inflammation, steroid resistant, steroid therapy, steroid-resistant asthma

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Preliminary results for two phase III trials evaluating Prochymal for the treatment of acute graft versus host disease (GvHD) have been announced by Osiris Therapeutics, Inc.

GvHD is considered to be one of the most common complications of bone marrow transplantation that is a life-endangering ailment without any approved treatment option till date.

From News-Medical.Net:

Protocol 265 was designed to evaluate Prochymal as a first-line agent for the treatment of acute GvHD in combination with steroid therapy. The majority of patients in this trial were suffering from skin GvHD, which responded significantly better to steroids than had been previously reported in controlled trials. This high response rate to standard of care diminished the potential for Prochymal to demonstrate an effect.

In the more severe, steroid-refractory GvHD setting (protocol 280), the benefit of adding Prochymal to second-line therapy was evaluated. Prochymal approached statistical significance for the primary endpoint in the per-protocol patient population which is the group of patients that met all of the study protocol requirements, such as inclusion and exclusion criteria. Additionally, Prochymal significantly improved response rates to liver and gastrointestinal GvHD, for which there is currently no known reliable therapy. Notably, the Prochymal cohort had more severe GvHD (27% of Prochymal patients had grade D GvHD, the most severe form, vs. 16% of placebo patients,>

Osiris plans to file an amendment with the FDA with intent to broaden the entry criteria including severe GvHD of the liver, on the basis of steroid-refractory GvHD trial results.

C. Randal Mills, Ph.D., President and Chief Executive Officer of Osiris Therapeutics, remarked that further analysis is required to gain a complete appreciation of the rigorous, double-blind, placebo-controlled trial results.

Tags: acute graft versus host disease, bone marrow transplantation, GvHD, Prochymal, steroid, steroid therapy

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As per the results of a research conducted at the National Jewish Medical and Research Center, the bodies of black asthmatic children are more likely to turn down the benefits of steroid treatment as per Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

It was highlighted that black children are more resistant to asthma steroid therapy than their white counterparts.

From News.Bio-Medicine.Org:

“Our results suggest that children with steroid-resistant asthma are more likely to be African-American, to have required treatment with oral steroids at an earlier age and to require larger amounts of oral steroids for only marginal control of their asthma,” said Joseph Spahn, M.D., a pediatric allergist and director of the Immunopharmacology Lab at National Jewish.

Other recent epidemiological studies have shown that blacks with asthma are sicker and have a higher mortality rate than whites with asthma. Doctors at National Jewish now are trying to determine whether blacks have a more vigorous immune response to airway inflammation–which means that higher doses of steroids must be used to control inflammation–or a poor response to steroids secondary to a genetic resistance to the drugs.

“The theory is that with ongoing airway inflammation you get worsening asthma and diminished steroid sensitivity,” Dr. Spahn said.

This study of 164 teen-agers treated at National Jewish also showed that 25 percent of the group was steroid resistant. Children with less than a 15 percent improvement in lung function following a “burst” of inhaled steroids–high doses over seven days–were considered steroid resistant.

“Twenty-five percent of the kids admitted to National Jewish have steroid-resistant asthma, which is much greater than anyone thought,” Dr. Spahn said.

The results of this study were published in the Journal of Allergy and Clinical Immunology. It is expected that more studies would soon be in the pipeline to ascertain if the black teens are also prone to have a more vigorous immune response to airway inflammation or not.

Tags: airway inflammation, steroid resistant, steroid therapy, steroid-resistant asthma

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Adam Vasser of Los Altos, California, was an active kid with a flair for baseball until one day when his heart was attacked by a mysterious virus requiring a need for a heart transplant. He underwent steroid treatment in the long term for preventing rejection of transplant leaving him to lead his life with osteonecrosis, an excruciating knee disorder.

Now at 23 and undergoing 15 knee and heart surgeries, he is back to play baseball again, all due to a new technique known as cellular grafting.

From News-Medical.Net:

The new surgical technique involves transplanting cellular material from the pelvic area into the knee. Two years after surgery, Goodman said, all three patients had returned to nearly normal activity and knee function with no complications.

“It’s a fairly simple procedure,” said Goodman, the Robert L. and Mary Ellenburg Professor in Surgery at the Stanford University School of Medicine.

Osteonecrosis of the knee is a rare disorder. When it occurs in young people, it’s most often the result of steroid therapy and is called secondary osteonecrosis. The bones in the knee start to die from a loss of blood supply, leading to severe pain, progressive arthritis and eventually the need for artificial joint replacement.

“Many patients do OK without surgical treatment,” Goodman said. “With those patients, I wait and prescribe pain medication.” But for young patients who still have a lifetime of activity ahead of them, Goodman wanted alternatives.

The 60-minute surgery, known as osteoprogenitor cellular grafting, involved scooping out the dead bone and thereafter filing the space in with a new cellular matter. It was theorized by Goodman that use of bone cells is better than using traditional bone grafting for these kinds of cases. A longer-term follow-up study with a larger number of patients was recommended by Goodman, an orthopedic surgeon Stuart Goodman, MD, PhD.

Tags: cellular grafting, knee disorder, osteonecrosis, steroid therapy, steroid treatment, transplant

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