The biological rationale for why large doses of corticosteroids given repeatedly over several weeks may help individuals with lupus has been uncovered by researchers at UT Southwestern Medical Center.

Lupus is a chronic inflammatory disease that affects more than 1 million people in the United States. Unlike the anabolic steroids abused by athletes for bulking up muscles, corticosteroids are routinely used to treat inflammation in lupus patients.

From News-Medical.Net:

In a study published in a recent issue of Nature, researchers at UT Southwestern and other institutions show in blood cells that giving very high doses of intravenous corticosteroids early and frequently in the course of the disease is more effective at killing the cells that drive lupus than giving the standard limited intravenous steroids followed by high doses of oral corticosteroids over a period of months. The cells used came from lupus patients as well as from animal models of lupus.

“By giving the very high dose early and frequently in the course of the disease, we could actually end up using much less steroids in the long run,” said Dr. Marilynn Punaro, professor of pediatrics at UT Southwestern and co-author of the study. “This finding suggests that by doing so, we might be able to get the disease under control more quickly and patients might experience fewer long-term side effects.”

Dr. Marilynn Punaro, professor of pediatrics at UT Southwestern and co-author of the study and director of the pediatric rheumatology division at UT Southwestern, said that steroids are probably always going to be a short-term fix because they work fast and powerfully.

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Brian McNamee, an important figure in investigation by George Mitchell into steroid use in baseball, breathe a little easier after revealing the complete truth and putting an end to his involvement with sprawling steroid probe of the government.

From NYdailynews.com:

“For Brian, to get him ready to testify, it was important to walk him through his story, grill him on his recollections, and make sure he was credible. Before the committee, Brian stayed focused on the relevant events involving Roger Clemens - most importantly when and how he injected Clemens - and gave clear and crisp answers,” said Paoletta. “Brian stepped up to the challenge, did a great job. And that’s why he is not facing a perjury indictment.”

McNamee praised his lawyers’ work, telling The News, “My attorneys did their due diligence all along. They’re doing it the right way.”

The personal toll on McNamee, however, has been vast. The legal bills to defend a defamation suit Clemens filed against him in January of 2008 have mounted and he has had trouble finding work as a trainer. He recently began working in a Long Island office.

McNamee’s friend Kirk Radomski, the former Mets clubhouse attendant who supplied steroids to ballplayers, said Brian told the truth and what he was supposed to do.

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Performance enhancing qualities of non-steroidal and tissue-selective anabolic agents such as Selective Androgen Receptor Modulators (SARMs) are prompting a demand high, according to researchers from the German Sport University Cologne in Germany.

SARMs represent a promising class of therapeutics for treating diseases such as benign prostatic hyperplasia (BPH), sarcopenia, osteoporosis, and cancer cachexia and gaining popularity in the sports doping community as they provide benefits of traditional anabolic/androgenic steroids such as testosterone with fewer unwanted side effects.

From Sciencedaily.com:

In 2008, the World Anti-Doping Agency (WADA) prohibited the use of SARMs in sports due to their potential for misuse. WADA closely cooperates with pharmaceutical and biotechnological companies, as well as medicine agencies and drug evaluation bodies on the issue of therapeutics being misused in sports. WADA’s preventive approach was validated with the recent finding of a commercially available, non-approved arylpropionamide-derived SARM termed Andarine. This product, declared as green tea extracts and face moisturizer to pass customs, was available on the Internet at a discount price of $100 USD.

Mario Thevis, Ph.D. remarked that the study demonstrates that the misuse of therapeutics by athletes, without clinical approval, cannot be dismissed.

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According to a lawyer representing the American baseball superstar, Barry Bonds, steroids in the form of unknowingly used creams and oils may have been used by Bonds.

It is being claimed that Bonds made use of these substances out of blind faith on Greg Anderson, his personal trainer and long-time friend.

From News.bbc.co.uk:

Anderson faces steroid distribution charges after an investigation into the Balco laboratories.

The firm is at the centre of a wide reaching probe into doping in the US.

“Barry had no reason to believe he was taking anything illegal, administrated by his best friend in the world,” said attorney Mike Rains.

Rains said that Bonds used the cream on his arm and what was described as flaxseed oil on his tongue.

It seems that there is no respite for the game of baseball, which has been haunted by accusations of steroid use by some of the biggest names in history of the game.

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John McEnroe, the former Wimbledon champion and tennis great, has unwittingly admitted that he made use of steroids for six years.

The steroid admission came after a similar admission by Greg Rusedski that he tested positive for nandrolone, the banned steroid.

From News.bbc.co.uk:

“I was being given a form of legal steroid they gave to horses until they decided it was too strong even for them,” said McEnroe.

“I’m not sure some of the strong, anti-inflammatory drugs are that far removed from illegal ones.”

McEnroe added: “People have to become more aware of what they are putting into their bodies.

McEnroe also remarked that people are generally administered drugs too readily.

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Roger Goodell, the NFL commissioner, recently remarked that he is in the favor of expanding the regular season to 17 or 18 games over the next few years. If this proposal gets the go-ahead, every team will be getting an extra home game and they will also be facing an opponent at a neutral site.

With accusations of over-fatigued players and steroid use in baseball plaguing the game, this comes as no respite and it will not be long before more players jump into the steroid brigade to sustain their positions and keep off the competition at bay.

From Weblogs.baltimoresun.com:

The suggestion that these games would just be replacing preseason games already on the schedule is a joke. We all know that most of the people playing in those games won’t even be on the roster two weeks after the final whistle. The toll on the starters — especially positions that regularly require violent collisions — would be far, far greater than in preseason games.

If the NFLPA does go ahead with Goodell’s proposal, they ought to, at the very least, ask for this concession: If we want to take steroids or human growth hormone to stay healthy, or smoke marijuana for medicinal reasons to deal with the pain, let us.

You might laugh, but that’s the only way to make this proposal work. It’s ridiculous to pretend that drugs aren’t already a major part of life in the NFL. Teams could literally not field a full roster each week without painkillers, legal or otherwise. Marijuana isn’t just a recreational drug for a lot of NFL players, it’s the only way they can get out of bed on Monday mornings. And it’s much less addictive than a painkiller like Vicodin, which is legal.

Kevin Van Valkenburg of the Baltimore Sun reacted to the proposal by remarking that players should then be given the complete freedom to make use of steroids, HGH, or even marijuana to combat pressure.

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The use of synthetic hormones such as Kigtropin could lead to improved muscle definition but the use is also associated with possible side effects such as blood clotting, paralysis, or a prison sentence. However, none of these effects have the ability to discourage users of anabolic steroids and performance enhancing drugs.

Kigtropin, a brand name for synthetically produced human growth hormone, is used for replacing the naturally produced hormones in the pituitary gland.

From Guardian.co.uk:

“I have carried out a study which showed that human growth hormone increased muscle mass in steroid users whose muscle growth had flattened out. Also, it has been shown to increase cartilage growth and repair – there is no shadow of a doubt that users will have an increased healing rate.”

Yet doctors warn that growth hormones are illegal without a licence – those found supplying them can face 14 years in prison and an unlimited fine. Even more worryingly, users of the hormone could be dicing with death. Nearly all of the Kigtropin entering this country is smuggled in or bought online with no control or guidance on how to take it. Mick Hart, author of the Layman’s Guide to Steroids, says: “The danger is 99% will use it irresponsibly – taking way too much or not knowing how to inject it. Dealers want you to take as much as they can sell you. Cycles of hormone use used to be around eight weeks long and then some time off – now people are taking them solidly for two to three years.”

Despite the fact that use of human growth hormone (HGH) can lead to severe health complications, more and more individuals are relying on HGH for attaining physique of their dreams as results are worth any risk for them.

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According to a major study conducted to examine the interactions associated with SSRI antidepressants, the risk of cataract gets higher among seniors making use of such drugs. The risk appears to increase by as much as 15 percent that could possibly mean 22,000 cataract cases attributable to antidepressant use in the United States alone.

The study was led by Mahyar Etminan, PharmD, of Vancouver Coastal Health Research Institute, Canada and examined data for nearly 19,000 people age 65 or older, all of whom also had cardiovascular disease.

From Sciencedaily.com:

The effect was strongest for three SSRIs: Luvox (fluvoxamine) increased risk by 39 percent, Effexor (venlafaxine) by 33 percent and Paxil (paroxetine) by 23 percent. The apparent increased risk was associated only with current, not past, drug use. Some antidepressants did not appear to be associated with cataract risk, but this could have been because the numbers of study participants using these drug types were too small to show effects, or because only specific agents in certain medications are related to cataract formation. These questions need further study.

“The eye’s lens has serotonin receptors, and animal studies have shown that excess serotonin can make the lens opaque and lead to cataract formation,” Dr. Etminan said. “If our findings are confirmed in future studies, doctors and patients should consider cataract risk when prescribing some SSRIs for seniors,” he added.

It is worthwhile to note here that beta blocker medications and oral and inhaled steroids have been linked by an earlier research in context of higher cataract risk.

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According to transplantation researchers at the University of Cincinnati (UC), post-transplant patients who are not administered with corticosteroids are better placed than their counterparts on steroids.

It was reported by the researchers that post-transplant patients off steroids experienced improved graft survival rates, reduced early mortality, and fewer cardiovascular events than patients administered with steroids.

From Sciencedaily.com:

UC researchers are also reporting results of shared protocols on the bortezomib treatment for antibody-mediated rejection. After presenting their bortezomib findings at the 2009 ATC, UC researchers created the START collaborative to share standard of care treatment protocols for bortezomib therapies. Through the collaborative, transplant centers worldwide have requested this information to treat individual patients with a variety of solid organ transplant types.

“The information shared from this partnership represents an international collaborative experience of treating this unmet need in transplantation that inevitably results in graft loss,” says Alloway. “Because transplant centers may have one to five antibody-mediated cases a year, it’s difficult to assess a potential new treatment. But when you are able to share every center’s cases together in one report, it’s easier to identify trends that support definitive design of future controlled trials.”

The finding was presented by researchers with the Division of transplantation and department of internal medicine at the American Transplant Congress (ATC), the annual meeting of the American Society of Transplantation on May 1-5 in San Diego.

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Muscles of the body retain a memory of fitness of the past as DNA-containing nuclei, which proliferate when a muscle is exercised, even as they wither from lack of use.

Study leader Kristian Gundersen, a physiologist at the University of Oslo in Norway, suggested that the findings highlight that exercise early in life can help in fending off frailness in the elderly besides raising questions about how long doping athletes should be banned from competitions.

From Sciencenews.org:

“It does fly in the face of a lot of peer-reviewed, published data,” he says. But the selective death of just some of the nuclei in a muscle cell would require a special kind of apoptosis. “The conventional wisdom doesn’t make much sense from a cell and molecular perspective,” Schwartz says. Gunderson’s group has come up with an explanation that seems more plausible. “Their data just feels right.”

If the results hold up in people, sports agencies may want to reconsider how long they ban athletes suspended for taking steroids. Previous research has shown that testosterone boosts the number of nuclei in muscle cells beyond the amount produced by working out. “If you have nuclei that last forever, then you would also have an advantage that could last forever,” Gundersen says.

Well, maybe not exactly forever. As people age, their ability to build muscle mass declines. The new study suggests that pumping muscles full of nuclei early in life could help stave off muscle loss with age. “This could be an argument for mandatory physical training in schools,” Saltin says.

This finding was reported online by researchers on August 16 in the Proceedings of the National Academy of Sciences.

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