Guggulsterone: Effective for curing Osteoarthritis and Obesity

Guggulsterone is one of the purest and popular forms of medication to cure osteoarthritis and obesity. It is also used for cholesterol management and disorders of the skin such as acne. Guggulsterone (GS) is an active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, which is used in the treatment of many human ailments such as inflammation, obesity, and dyslipidemia.

Guggulsterone E and Z act as antagonists at the site of farnesoid X receptor to facilitate greater cholesterol catabolism and excretion out of the body. Guggulsterone has the ability to reduce production of hepatic steroid in the body paving the way for an increase in the catabolism of plasma LDL cholesterol. Guggulsterone E and Z can facilitate an increase in hepatic binding sites for LDL cholesterol to increase LDL clearance.

Bodybuilders and professional athletes make use of Guggulsterone as it stimulates the thyroid gland to produce more thyroid hormones such as thyroxin. This means that there will be an increase in the rate of metabolism and fat will burn at a faster pace in the body.

Chemical Composition & Characteristics

The IUPAC name of Guggulsterone is (8R,9S,10R,13S,14S,17E)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione. Its chemical formula is C21H28O2and its molecular weight is 312.445820 [g/mol].

Recommended Dosage

The recommended dosage of Guggulsterone is 75-150 mg on a daily basis.

Possible Side-Effects

Some of the possible side-effects of Guggulsterone are nausea, headache, diarrhea, restlessness, hiccups, abdominal pain, and rashes.

Precautions & Contraindications

Guggulsterone is contraindicated for individuals with an existing thyroid ailment. Furthermore, pregnant or pregnancy-suspecting women should avoid Guggulsterone as it may stimulate menstrual flow.