Category Archives: Performance Enhancing

SARMS Cycles

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MK-2866 Ostarine SARMSSARMS can be cycled and utilized in many different ways. The best way to utilize them are running them as a bridge in between cycles. A bridge is the time when you have completed PCT from a previous cycle and are recovering in preparation for your next cycle. This can be a very trying time for many, as they can experience depression, loss of size, strength, motivation and hard earned gains from previous cycles. SARMS truly shine at this time. SARMS can be ran during this period and can not only help to maintain gains but can add to them or clean them up immensely. Many users have a better feeling while on SARMS than they do on cycle.

It is important to understand how to use SARMS and how to run them properly. SARMS are nowhere near as suppressive as anabolics and are not toxic but they can have some suppression and it is imperative to run the proper supports along side of them to ensure that recovery is smooth and efficient. SARMS do not aromatize but the SARM ostarine (mk-2866) has shown to cause possible gyno issues for some, so it is important to be prepared for this. A typical, and most effective SARMS cycle is ran for 8 weeks. A mini pct is required after a SARMS cycle. This pct is only necessary for a period of three weeks and a SERM is not required. Recovery is very quick and a user is typically recovered a week after the mini pct is completed. It is important to take time off of SARMS after a cycle is complete so that the body does not become accustomed to their use thus taking away from their effectiveness.

There is a support stack that I have put together that will completely cover a user for a full 8 week cycle and the three week mini pct. This is a complete support stack and the explanation of each product and how to use it as well as ordering information can be found here: http://needtobuildmuscle.com/store/Test-boosting-PCT/Support-Stack-p286.html

The only time a mini pct would not be needed is if a user ran GW-501516 as a stand alone cycle. Any other use of SARMS will require a mini pct and will absolutely need to have supports ran alongside.

SARMS can be run alongside any anabolic, but it is not going to be an optimal way to use them. There will competition amongst receptors and this will also take away the opportunity to utilize SARMS as a bridge. Even if a user is on TRT or cruising, SARMS can be utilized in a bridge like fashion. I am going to provide different types of SARMS cycles that can be utilized for the different types of goals that you may have.

THE TRIPLE STACK

GW-501516 SARMSThis is the most commonly used SARMS stack. Quite simply, this stack can be used for any set of goals that you have. The recomping effect on this stack is unbelievable. You can cut on this stack, you can aim for size, you can maintain, you can do it all! Playing with your doses will coordinate with your goals. I like to add albuterol to this stack to add extra endurance and cutting while still being able to hold and add muscle. Here is the stack:

1-8  Ostarine 25 mg day dosed once a day in the a.m.

1-8  S4 50 mg day… split doses… 25 mg in the a.m. and 25 mg in the p.m.

1-8  GW-510516 10-20 mg day… split doses 12 hours apart

1-8  HcGenerate        

1-8  D-spark          

3-8  Albuterol 12-18 mg day

Mini pct  9-12

Hcgenerate ES

NOW, if you want to aim this stack even more towards a bulk, then you can drop ostarine and add LGD-4033. The stack would look like this:

1-8  LGD-4033 10 mg day dosed once a day in the a.m.

1-8  S4 50 mg day… split doses… 25 mg in the a.m. and 25 mg in the p.m.

1-8  GW-510516 10-20 mg day… split doses 12 hours apart

1-8  HcGenerate        

1-8  D-spark          

3-8  Albuterol 12-18 mg day

Mini pct  9-12

Hcgenerate ES

LGD-4033 SARMSI do not recommend using LGD and Ostarine in the same cycle because of their similarities. This would end up being counter productive to your cycle.

Any SARM can be ran as a stand alone or you can add or drop anything that you want. It is important to make sure that you are running ALL of your proper supports and running your mini pct. As previously stated, the ONLY SARM that would not require a mini pct or supports is GW-50156 ran as a stand alone. You must protect yourself and give yourself the proper recovery on any other SARMS cycle. These are the most effective ways to run SARMS. There are several combinations you can run, but the triple stack is where SARMS are at their best and provide the best results.

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Posted in Muscle Building, Performance Enhancing, SARMS

Selective Androgen Receptor Modulators (SARMS)

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Selective Androgen Receptor Modulators (SARMS)

FACTS AND COMPARISONS TO ANABOLICS

MK-2866 Ostarine SARMSThe biological actions of androgens are primarily mediated by the androgen receptor. The androgen receptor is expressed in target tissues as the prostate, skeletal muscle, liver, central nervous system, with the highest expression being produced in the prostate and adrenal gland. Men with rare mutations of the androgen receptor have lower lean mass and higher body fat than normal men. The physiological importance of the androgen receptor has been demonstrated as animal studies that administer androgen receptor antagonist (drugs that block the actions of androgens binding to its receptor) during muscle overload have suppressed muscle hypertrophy. This suggests that the androgen pathway has a significant effect in exercise-induced muscle hypertrophy and emphasizes the importance of the increase in the number of androgen receptors in exercised muscle. Additionally, when scientists administered the androgen antagonist flutamide, to rats undergoing puberty resulted in a suppressed muscle growth. Researchers developed SARMS to minimize the side effects of testosterone y promoting full anabolic activity in muscle and bone, while minimizing the undesirable side effects on prostate, hair, skin, and without affecting sperm production and sex drive.

SARMS have full anabolic activity in muscle and bone, yet have minimal effect the on prostate. SARMS are highly specific to the androgen receptor as they have a 1000-fold less binding affinity for any other receptor. SARMS are orally available and so far seem to have minimal effect on the liver. SARMS have a number of beneficial effects in bone, muscle, and sexual function independent from the conversion of androgens into estrogens.

SARMS: Anabolic Activity in Muscle and Bone with Minimal Effect on the Prostate.

GW-501516-SARMSTestosterone induced increase in muscle mass is associated with hypertrophy of both type I and type II fibers and increased satellite cell activation. The effect of testosterone is thought to be mediated by the androgen receptor as muscle growth factors in vitro (in test tubes) are blocked by the androgen antagonist bicalutamide (blocks the actions of testosterone from binding to the androgen receptor), indicating that the effects of testosterone are mediated thru the androgen receptor pathway. The androgen receptor signaling pathway enhances the expression of myogenin (Myogenin is an important mediator of muscle growth) and accelerates the expression of muscle growth factors. AR expression is widespread throughout the body and androgens play a desirable role in promoting bone strength, increasing muscle mass, decreasing fat tissue, and increasing muscle strength. A study in the Journal of Steroid Biochemistry and Molecular Biology reported that when resistance trained men had muscle biopsies taken the greatest predictor of males 1-RM strength was not testosterone but the androgen receptor content in the thigh muscle. SARMS are muscle specific compared to testosterone. For example, one study reported that oral doses of SARMS exhibited a >50-fold selectivity for muscle over the prostate. Testosterone propionate had only a 2-fold selectivity for muscle versus prostate. Other studies have reported that the SARM S4 produced greater anabolic activity in muscle than testosterone propionate but had less androgenic activity on the prostate. Additionally, a study published in the journal of Endocrinology reported that SARMS were just as anabolic in muscle compared to testosterone cypionate but less androgenic. In that study, testosterone cypionate increased prostate weight and muscle growth in a dose dependent manner, meaning the more testosterone they used the more muscle hypertrophy was experienced but with similar increases in prostate growth. SARMS showed more anabolic activity in muscle with minimal stimulation of the prostate. Compared with testosterone cypionate, SARMS were more than 200 times more potent in stimulation of muscle and 80 times more selective for muscle versus prostate. Additionally, both testosterone cypionate and SARMS decreased adipose tissue in a dose dependent manner. The study demonstrated that SARMS has the potential to provide a greater safety delivery than testosterone, mainly with low stimulation of the prostate, yet hyperanabolic effects on muscle tissue. SARMS have also been shown to increase skeletal muscle strength.

SARMS SUMMARY:

S-4 bottle SARMSIt should be noted that testosterone increases muscle mass thru multiple pathways: increasing protein synthesis, increasing GH secretion, increasing IGF-1 levels, increasing satellite cell activation, and increasing androgen receptor concentration in muscle. The androgen receptor binding affinity of steroids is only partly responsible for the androgen receptor mediated effects of both physiological and synthetic steroids. For example, it is well known that some steroids are potent anabolic agents, yet bind to the androgen receptor weakly. Another interesting fact is that testosterone can increase lean body mass and reduce fat mass in androgen-deficient men. The skeletal muscle androgen receptor may exert both receptor dependent (testosterone, DHT) and independent actions (intramuscular IGF-1) in the functionally overloaded muscle, which may be related to growth factor signaling. The androgen receptor in muscle is decreased during aging which may be an important contributing factor to the age related decrease in muscle mass that occurs with aging. The development of SARMS for clinical use is promising based on preclinical data owing to their selective high anabolic activity in muscle. SARMS could be useful for the prevention of many muscle wasting diseases and age related decreases in muscle mass without unwanted side effects associated with testosterone. In addition, SARMS may be prevent or treat prostate enlargement as SARMS is a partial agonist on the prostate. SARMS also lack estrogenic activity and do not under go 5a-reduction so it can’t be converted to DHT. The side effects are minimal and the results speak for themselves. d

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Posted in Performance Enhancing, SARMS

GW-501516

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GW-501516

THE ULTIMATE PERFORMANCE ENHANCER

GW-501516-SARMSGW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue.

GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions.

GW has also shown to dramatically increase endurance and recovery. In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure.

In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.

GW-501516 Uses:

GW has many benefits but has two primary uses. The most common use of GW consists of the extreme amount of endurance and recovery increase. The results with GW use regarding endurance increase are staggering. GW was banned by the WADA (World Anti Doping Association) in 2009 because it provided such a large advantage to its user over the competition. GW acts quickly and the results are drastic. A user can expect to see an endurance increase within a few days of use. The common dosage for these types of results are 10 mg a day but can be taken up to 20 mg a day. Either way, a significant increase in endurance will occur.

The other main use of GW is to aid in fat loss. GW has shown to melt away fat at a rapid pace. Another strong component of GW is that it is non catabolic, meaning it allows a user to lose fat and not have to sacrifice muscle. Many people that are on a diet burning fat are also sacrificing a lot of muscle, but GW allows a user to hold on to much more muscle than a standar fat lass diet or other fat loss compound would allow. GW also shines when ran in conjunction with other SARMS. When stacking GW with Ostarine and S4, users can add lean muscle while still losing weight and body fat. This makes GW highly desirable for many. The most optimal dosage for fat loss is 20 mg a day but users will still be able to receive this benefit at 10 mg a day.

GW 501516 can be ran in 8-12 cycles and can also b ran in conjunction with any SARM, steroid or supplement. As with any other steroid or supplement, it should be cycled properly to avoid any possible side effects and the keep it as effective as possible.

Dosing Timing:

GW also has a very long half life, so it can be dosed once a day or split 12 hours apart. I have found that splitting the dose works nicely. GW is very effective when taken 30-45 minutes prior to working out.

Side effects:

There are constant debates and many studies arguing the potential side effects for a user. There are studies showing that GW has caused cancer in rats while other studies refute it. There is not enough data to validate this substantial of a claim. GW has shown to have little to no side effects. There is no suppression, no toxicity and no other common side effects. The studies that were done were over very long periods of time and not at a dosage that a human would run. GW is a favorite among many.

Benefits of GW 501516:

  • Extreme increases in endurance and recovery
  • Extreme fat melting
  • Long Half Life Making Dosing Optimal
  • Lowering of Bad Cholesterol and Increasing Good Cholesterol
  • Minimal Side Effects
  • Can be ran up to 12 weeks
  • Stacks well with everything
  • Non catabolic
  • Excellent energy
  • Excellent overall sense of well-being and feeling

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Posted in Performance Enhancing, SARMS