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GW-501516-SARMSGW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue.

GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions.

GW has also shown to dramatically increase endurance and recovery. In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure.

In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.

GW-501516 Uses:

GW has many benefits but has two primary uses. The most common use of GW consists of the extreme amount of endurance and recovery increase. The results with GW use regarding endurance increase are staggering. GW was banned by the WADA (World Anti Doping Association) in 2009 because it provided such a large advantage to its user over the competition. GW acts quickly and the results are drastic. A user can expect to see an endurance increase within a few days of use. The common dosage for these types of results are 10 mg a day but can be taken up to 20 mg a day. Either way, a significant increase in endurance will occur.

The other main use of GW is to aid in fat loss. GW has shown to melt away fat at a rapid pace. Another strong component of GW is that it is non catabolic, meaning it allows a user to lose fat and not have to sacrifice muscle. Many people that are on a diet burning fat are also sacrificing a lot of muscle, but GW allows a user to hold on to much more muscle than a standar fat lass diet or other fat loss compound would allow. GW also shines when ran in conjunction with other SARMS. When stacking GW with Ostarine and S4, users can add lean muscle while still losing weight and body fat. This makes GW highly desirable for many. The most optimal dosage for fat loss is 20 mg a day but users will still be able to receive this benefit at 10 mg a day.

GW 501516 can be ran in 8-12 cycles and can also b ran in conjunction with any SARM, steroid or supplement. As with any other steroid or supplement, it should be cycled properly to avoid any possible side effects and the keep it as effective as possible.

Dosing Timing:

GW also has a very long half life, so it can be dosed once a day or split 12 hours apart. I have found that splitting the dose works nicely. GW is very effective when taken 30-45 minutes prior to working out.

Side effects:

There are constant debates and many studies arguing the potential side effects for a user. There are studies showing that GW has caused cancer in rats while other studies refute it. There is not enough data to validate this substantial of a claim. GW has shown to have little to no side effects. There is no suppression, no toxicity and no other common side effects. The studies that were done were over very long periods of time and not at a dosage that a human would run. GW is a favorite among many.

Benefits of GW 501516:

  • Extreme increases in endurance and recovery
  • Extreme fat melting
  • Long Half Life Making Dosing Optimal
  • Lowering of Bad Cholesterol and Increasing Good Cholesterol
  • Minimal Side Effects
  • Can be ran up to 12 weeks
  • Stacks well with everything
  • Non catabolic
  • Excellent energy
  • Excellent overall sense of well-being and feeling


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Posted in Performance Enhancing, SARMS