S4 (Andarine)

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S-4 bottle SARMSS4 (ANDARINE) is a SARM that was developed for treatment of muscle wasting, osteoporosis and benign prostatic hypertrophy. S4 is effective in not only maintaining lean body mass, but increasing it while reducing body fat.

The way that S4 works is by binding to the androgen receptor demonstrating bone and muscular anabolic activity. By binding to the androgen receptors, S4 alters the expression of genes and increases protein synthesis. This leads to the building of quality muscle. S4 can produce muscle growth as steroids do without the type of side effects that steroids produce.

S4 has shown the ability to increase lean body mass, reduce body fat, improve skeletal muscle strength and prevent bone loss.


There are three main uses for S4. These are CUTTING, RECOMPING AND LEAN MUSCLE AND STRENGTH GAINS. S4 truly shines in all three of these aspects.

When it comes to cutting, S4 produces winstrol like effects with masteron type of aesthetics. S4 truly shines aesthetically for the user that has a much lower body fat. The muscles hardening effects it produces happen rapidly and are generally noticeable within a few days. The lean muscle that S4 provides is very keepable and extremely noticeable.

When recomping, S4 also shines. S4 allows a user to increase their lean muscle mass while reducing body fat. A user can produce some of the cleanest muscle gains they will experience on any type of cycle and enjoy seeing the fat melt off. These makes S4 extremely desirable.

The strength gains that S4 produces are rapid and lasting. The gains are generally all kept and are very clean. There is an excellent sense of overall well being that S4 provides that makes a user feel just as good, if not better than when they are on a steroid cycle.

Proper Dosing and Side Effects:

When it comes to dosing S4, it is a very delicate matter. S4 has two side effects that must be addressed. The main side effect of S4 is the vision effect. When run at the 50mg+ doses, many users report vision disturbances. Now these are only present when using S-4 and quickly disappear when S-4 use is discontinued.

The side effects are caused by the M1 metabolite and include night-time blindness and a slight yellowish tint to the vision for some users.

Although these side effects are temporary, if they are still a concern, as suggested earlier, a 5 on 2 off protocol where S-4 is used for 5 days followed by a 2 day break (then this cycle is repeated) would be the suggested dosing method.

The other main side effect is the small amount of suppression that comes with S4. The suppression is nowhere near the amount that comes along with steroid use but it is still something that needs addressed. The use of hcgenerate on cycle helps to keep this suppression to a minimum. A small mini pct ran for 3 weeks is all that is needed with S4. HcGenerate ES ran for the entire time will provide sufficient recovery.

As far as the proper dosing goes for S4, I have written a method that should be followed that allows a user to get the most out of S4 that they can. Here is my method in full detail.


Okay everyone… I wanted to write this up to make sure that everyone knows how to properly dose S4… As most of you know, the common side effect associated with S4 is the night vision issue. This results in one of two or both of these issues: A yellow tint associated with vision at night and/or a hard time adjusting to darkness or light… Normally the adjustment period is very quick but can effect some much worse than others. Basically, s4 can bind to the receptor in the eye causing these problems. UNDERSTAND that it is IMPOSSIBLE to know if this will happen to you and at what dosage this may happen… 50 mg is the general starting spot for dosing. Some people get the vision issue immediately even at this moderate dose. Some are able to get up to 100 mg a day with very minimal problems… There is no way to tell what category you fall into until you try… The vision issue is not permanent and the half life on s4 is very short (around 4-6 hours) Some people are forced to go to dosing s4 for 5 days and then taking 2 off because they cannot handle the vision issue… I try to do everything I possibly can to avoid this because I do not want to miss any days of usage…

So, it is important to understand how to dose s4 properly. Some people are content at staying at 50 mg for an entire 8 week cycle. Others, want to increase the dosage but there is a very specific protocol to follow to ensure that vision issues are kept to a minimum…

I compare this protocol to fighting Mike Tyson on Mike Tyson’s punchout. If anyone has ever played the game they will appreciate this comparison. When you fight Mike Tyson, the first 1:20 seconds of round 1, if you are hit just one time you are knocked down… This is the danger zone… Once you get past that first 1:20 you are much safer but you still must proceed with caution because the fcker is still dangerous…

This is the same with S4… You must go 2 weeks at 50 mg… If you get through the 2 weeks with minimal to no vision issues then you past the danger zone… You are safe then to increase your dosage but must proceed with caution… After two weeks you can bump to 60 mg… Now you are testing the waters… You must now stay on 60 mg between 10-14 days… I would say 12 is the safest bet… Then it is okay to increase again to 70 mg if you are able to… I feel like between 70 and 80 mg is the sweet spot however there is benefit up to 100 mg… You should continue to follow protocol of 10-14 days on each 10 mg incremental increase… By following this protocol, you could get up to 100 mg for at least the last week… You should NEVER GO ANY HIGHER THAN 100 mg… As I mentioned, the sweet spot is between 70-80 mg… Every increase needs to be with extreme caution and if the vision issues begin, you know where your boundary is… Some of us are luckier than others in terms of receptor binding… DO NOT BE IN A RUSH to increase dosage… Following this protocol will be the safest and MOST EFFECTIVE way of dosing s4.

S4 has a very short half life of 4-6 hours. The dosage should always be split and taken 4-6 hours apart in equal amounts.


This is a list of the several benefits associated with S4:

  • 1/3 as androgenic as testosterone in muscle tissue.
  • Anabolic at doses above 50mg
  • Great for strength
  • Great for muscle hardness
  • Great for enhanced vascularity
  • Great for endurance (aerobic or anaerobic)
  • Accelerated fat loss above 50mg
  • Joint healing effects
  • Half life of 4 hours


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Posted in Cutting SARMS, SARMS