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Ostarine (MK-2866)

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Ostarine (MK-2866)


MK-2866 Ostarine SARMSOstarine (MK-2866) is a SARM that was developed for the prevention and treatment of muscle wasting. Future plans indicate that it will eventually be prescribed for the prevention of cachexia, atrophy and sarcopenia as well as for Hormone or Testosterone Replacement Therapy.

The way that ostarine works by binding to the androgen receptor demonstrating bone and muscular anabolic activity. Ostarine causes muscle growth by binding and activating the androgen receptor, which alters the expression of genes and increases protein synthesis. Ostarine exerts its anabolic effects on muscle tissue almost exclusively. It also minimizes atrophy during recover periods from surgeries and injuries making it desirable for so many different types of users and situations. Ostarine is extremely effective in maintaining and gaining lean body mass.

Ostarine USES:

Ostarine is extremely versatile and can be used for every type of goal in training. It can be used to bulk, to cut or to recomp. It truly shines as a recomp but provides effects in all three areas.

As a bulker, ostarine has shown to add up to 7 lbs. of lean muscle mass over an 8 week cycle. The optimal dose is 25 mg a day. The half life of ostarine is very long so it only needs to be taken once a day, preferably in the morning. Ostarine is the most anabolic of all the SARMS, so it provides the best chance of muscle gain. The gains that ostarine provides are very keepable and the muscle and size gained is very lean and clean. There is a significant strength increase as well.

As a cutter, ostarine should be dosed at 15-20 mg a day for 8 weeks. Ostarine would primarily fit into a cutting protocol for the maintenance of muscle mass while reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone, etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue. As Ostarine has anabolic effects, user can cut calories without having to worry about muscle or strength loss. Ostarine has also shown noticeable nutrient partitioning effects among users, another reason why it can be of great help when cutting.

Ostarine truly shines during a recomp. Ostarine works particularly well during a recomp because of its nutrient partitioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. Many users have shown that when ostarine is consumed at maintenance calories, they are able to lose weight yet still show increases in strength and muscle mass. Although Ostarine is taken orally, it is not methylated and is not toxic to the liver and does not have a negative effect on ones blood pressure. Therefore it can be run for longer than oral steroids. Ostarine can be used up to 12 weeks safely and still provide excellent benefits.

Injury Prevention:

Ostarine also has the benefit of healing as part of its versatility. The effects it provides translate to anabolism in bone and skeletal muscle tissue, which also allows it to be used in a variety of ways, such as treating osteoporosis and in conjunction with drugs that reduce bone density. It has excellent benefits when used for rehabilitation of injuries, especially bone and tendon related injuries.

Doses of 12.5mg per day is recommend for such purposes and improvement in joint movement that can be seen after just 6-8 days.

Estrogen Concerns:

SARMS do not aromatize, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens. However blood work from users has shown a slight elevation in serum estradiol levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses.

This elevation is extremely small and is no case for concern. If however you are absolutely concerned about slight increases in Estrogen, you can always opt for low doses AI’s, like aromasin or arimidex for added protection and prevention. The use of D-Spark is highly encouraged as opposed to an AI on cycle. Most instances where there have been gyno concerns are due to users abusing the dosing and exceeding the recommended 25 mg a day… Exceeding 25 mg a day is not advisable and when side effects start to occur.

Slight Suppression:

Ostarine has shown to be slightly suppressive when ran over 4 weeks. It is nothing to be alarmed about and nowhere near like running a steroid. HcGenerate is highly encouraged to be used on cycle to keep suppression to a minimum and to transition into pct smoothly. A 3 week mini pct is required after ostarine use is completed. HcGenerate ES ran for 3 weeks will provide the optimal recovery. A SERM can be used but it not required for pct. Recovery on SARMS is very quick and smooth as long as it is done properly.

Ostarine advantages and benefits:

Ostarine Summary

  • Anabolic even at doses as low as 3mg
  • Great for strength
  • Great for lean mass gains
  • Great for body recomposition
  • Great for endurance (aerobic or anaerobic)
  • Joint healing abilities
  • Half life of circa 24 hours – only once a day dosing required
  • It is non methylated so it is non toxic to the liver or blood pressure
  • Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent PCT of prescription SERMs like Nolvadex or Clomid is not necessary.
  • High oral bioavailability without significant damage to your liver as with oral steroids.
  • Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lives).
  • No need for a long time period off between cycles; the recommended time of period for normal steroid cycles would be Time on + PCT, so for a typical 6 week cycle and 4 week PCT, a user would have to wait another 10 weeks afterPCT to start another cycle where SARMS recovery requires minimal rest in between.
  • Ostarine also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category – hence there is little impact on cholesterol values.

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Posted in Anabolic, SARMS