Myopathies
are diseases of skeletal muscle which are not caused by nerve
disorders. Myopathies are characterized by skeletal or voluntary
muscles to become weak or wasted. Voluntary muscles are the muscles
whose actions are normally controlled by the individual.
There are many different types of myopathies. Some inherit the disease
while others get them with the use of steroids, or what is known as
steroid myopathy.
Steroid
myopathy causes weakness primarily to the proximal muscles of the upper
and lower limbs and neck flexors. Steroid myopathy can arise due to
excessive corticosteroid levels in the body. Increased level of
corticosteroid can either be due to excessive endogenous corticosteroid
production that may be caused by adrenal tumors. Steroid myopathy can
also be due to
steroid
intake.
It has been observed that
steroid
myopathy tends to arise when an individual uses
fluorinated
steroids
(
dexamethasone,
fluoxymesterone) as well as
nonfluorinated steroids
(cortisone, prednisone). The exact mechanism why steroid
myopathy occurs is not yet exactly determined but the generally
accepted theory is it may be brought about by unbalanced metabolic
pathways, including decreased protein synthesis, increased protein
degradation, and carbohydrate metabolism.
Discontinuance or decreased of corticosteroid intake usually resolves
the weakness observed with steroid myopathy; however, the length of the
recovery period varies. In some individuals recovery only takes a
couple of weeks while in others recovery takes several months.