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Chemical Name: Clenbuterol Hydrochloride
Drug Class: Lipolytic (fat burner)



Clenbuterol PicturesClenbuterol (often called just ďClenĒ) is used by athletes and bodybuilders for itís ability as a beta-2 agonist. It therefore stimulates your beta-2 receptors, which in turn help you to lose fat by allowing your body to release and burn more stored fat. Clen has been used for literally decades in the foreign veterinary world, for increasing the lean yield of livestock. It is clearly a very effective agent for this purpose, although its long half life and tendency to stay active in the body for long periods of time mean that vets in the United States arenít able to use it. This is also the reason why (although itís an asthma medication) itís not available to asthmatics in the US of A. Albuterol is Clenís shorter acting cousin, and thatís the FDAís drug of choice here. But in the world of athletics, Clenbuterol has a much longer history of use.

clenbuterol ripped abs

Specifically, itís used for fat loss, and since weíre talking about fat loss here, and this purpose is what itís most often used for by athletes. Briefly stated, Clen is used as a repartitioning agent, and what this means is simply that it will increase your ratio of Fat Free Mass (FFM) to Fat Mass (FM) [1]. When you use Clenbuterol, besides (of course) noticing some fat loss, youíll feel your body temperature rise a bit, and your appetite will be slightly repressed. [2]

Anyway, as you may have guessed, because the FDA doesnít allow Clenbuterol use in asthmatics, and the USDA doesnít allow it in livestock, there arenít a lot of human studies to really examine with regards to Clenbuterol. Unfortunately this makes research a bit difficult, as itís well known that animals have a some important differences in their beta-receptor type and concentrations, but animal studies are still quite useful here.

Clenbuterol is quite anti-catabolic and/or anabolic in almost every (animal) study ever done on it, although this hasnít been studied or confirmed in human studies [3]. Also, a trend we see with Clenbuterol administration in animals is that the doses used are very high- more than anyone Iíve ever heard of actually taking. So, what Iím saying is that if Clenbuterol is anabolic or anti-catabolic in humans, only mild anabolic or anti-catabolic effects can realistically be expected. We can take a look at horses given a human-like dose of clen (slightly over 1mcg/lb x2 a day) and exercised for nearly human-like times (20mins, 3x a week) showed very significant decreases in %fat (-17.6%) and fat mass (-19.5%). Interestingly, this significantly increased (+4.4%) at week 6 [1]. This has been one of the reasons I have never believed in the 2 weeks on and 2 weeks theory of Clenbuterol administration. Why wouldnít we want to use it for at least 6 weeks, considering the fact that it seems to have some profound effects during later administration. A ďsecond windĒ so to speak (get it? ďsecond windĒ? itís an asthma med! Ha! OkÖmoving alongÖ).

One of the primary drawbacks of Clenbuterol is that after a couple of weeks, it seems to stop working for most people. This is because it can cause a downregulation of pulmonary, cardiac and central nervous system beta-adrenergic receptors [4]. This is why it seems to stop burning fat for most people at that point. To counteract this, you can take some Ketotifen, Benadryl, or Periactim every 3rd or 4th week that you remain on Clenbuterol. These are prescription anti-histimines, so theyíll make you drowsy (take before bedtime).

Also, bear in mind that clen isnít great for your heart, and can cause some issues there (enlargement of ventricles, etcÖ) but most studies showing Clen to cause heart problems are with animals, and even though the dosing is almost similar to what humans take (in some studies its within range of what would be double of a large human dose...). Again, itís important to remember that animals have more beta-2 receptors and they cause certain event chains that humansí beta-2 receptors may not, due to their relatively high concentrations. Clen causes cardiac hypertrophy to some degree, in some cases and even dose-dependent apoptotic and necrotic myocyte death [5]. And since Clen depletes taurine [6] as do most if not all beta-agonists, you may want to supplement your Clen use with some Taurine.

One of the weirdest things about Clenbuterol is that even though itís an asthma medication, studies have shown reduced exercise (cardiovascular) performance with Clen [7], but some also show that Clen can alleviate exercise induced asthma [8]!

Clenbuterol is one of the easiest drugs to find proper dosing for, and Iíve always made the same recommendations as to finding the appropriate dose for you. Basically, start with 20mcgs upon rising. If the side effects (possible anxiety, and shaking or sweating) arenít too pronounced, then repeat that same dose again later in the day, and then once again in that day (again, if you find you can tolerate the effects). If you start experiencing intolerable sides, then decrease the does to where itís tolerable. If not, then start increasing the dose more, very gradually.

Donít go over 200mcgs, thoughÖand keep your Blood Pressure at (or under) 140/90. If your Blood Pressure goes over that, reduce your dose. If side effects are intolerable, decrease your dose.


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  1. ^ J Appl Physiol. 2001 Nov;91(5):2064-70
  2. ^ Int J Obes Relat Metab Disord. 1994 Jun;18(6):429-33
  3. ^ Ann Pharmacother. 1995 Jan;29(1):75-7
  4. ^ J Anim Physiol Anim Nutr (Berl). 2004 Apr;88(3-4):94-100
  5. ^ Muscle Nerve. 2005 Dec;32(6):767-74
  6. ^ Adv Exp Med Biol. 1996;403:233-45
  7. ^ Med Sci Sports Exerc. 2002 Dec;34(12):1976-85
  8. ^ Respiration. 1987;51(3):205-13

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