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Chemical Name: Cabergoline
Drug Class: Dopamine Receptor Agonist


Dostinex Profile

dostinex chemical

Fig 1. Dostinex Chemical Structure

Originally introduced by the anti-aging community to the bodybuilding world, this dopamine receptor agonist has the chemical name of 1-[(6-allylergolin-8ß-yl)-carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea and tablets of this drug include 0.5 mg of cabergoline and the list of inactive ingredients includes leucine, USP, lactose, and NF.

The biggest reason why this drug is admired by amateur and professional athletes is because it helps them reduce or eliminate the risks associated with excess prolactin that is common with use of harsh and aromatizable steroids like Trenbolone and Deca Durabolin. Furthermore, this drug is also useful for treating sexual dysfunction caused by excess prolactin besides gaining an erection between orgasms and reducing recovery time after intense workouts or weight training and strength training exercises. In addition to these advantages, the use of Dostinex is equally beneficial to combat estrogenic side effects such as oily skin, acne, gynecomastia, and bloating and treating health complications like galactorrhea and sexual dysfunction. It is also routinely indicated to patients with Parkinson's disease as it has the potential to work on information pathways and nervous system of the body. Dostinex is also admired for its ability to make athletes feel 'full' that helps in minimizing food cravings without dieting discomfort.


Fig 2. Dopamine

Dostinex is neither physically nor mentally addictive and is admired globally for its anti-prolactin, antidepressant, cognitive, and prosexual effects. Use of this drug for a period of six to eight weeks is also associated with a dramatic improvement in sense of well being and invincibility. Ideally, the recommended dose of Dostinex is 0.5 mg a week with a glass full of water. It is very important to realize that Dostinex (Cabergoline) is an extremely potent drug and should be used only after receiving a prescription from a medical practitioner. The practitioner may suggest cardiovascular evaluation and echocardiography to evaluate valvular disease before recommending this drug.

Use of this drug is not suggested to those suffering from uncontrolled hypertension or known hypersensitivity to ergot derivatives, pregnancy-induced hypertension, for example, preeclampsia, eclampsia, and post partum hypertension, history of pulmonary, pericardial, or retroperitoneal fibrotic disorders, or those having a history of cardiac valvular disorders. Cabergoline is also not advised to those suffering from thickening of the lining in the lungs/heart/behind the abdomen (pulmonary/pericardial/retroperitoneal fibrosis or heart valve disease and abnormal scarring.

People who are already using drugs like D2antagonists, such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide or drugs meant to treat migraine, mental illness, nausea, vomiting, and bacterial infections should never use this drug concurrently unless the same is specifically indicated by the medical practitioner. Furthermore, children, pregnant and lactating women, or those who may become pregnant while using it should avoid using Dostinex. The drug should not be handled by pregnant women as it can be absorbed by the skin to cause health complications.

Use of Dostinex should be stopped without any delay and medical assistance must be sought immediately if side effects such as weakness, tiredness, breast pain, hot flushes, dizziness, unusual sleepiness, abdominal pain, constipation, changes in behavior, rashes, loss of hair, irregular heart beat, breathing problems, or leg cramps or pain in the toes or fingers are noticed.

If Dostinex tablets or Cabergoline injections have expired, they should not be flushed down the toilet or poured into a drain. They should be discarded only after consulting a pharmacist or local waste disposal company.


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Material Safety Sheet


  1. ^ J Clin Psychiatry. 2004 Feb;65(2):187-90
  2. ^ Pituitary. 2005;8(1):39-42
  3. ^ CTreat Endocrinol. 2003;2(1):23-32. Review
  4. ^ Eur J Endocrinol. 2003 Mar;148(3):325-31

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