Human Chorionic Gonadotropin is
a substance that, in the human body,
mimics Leutenizing Hormone (LH
LH is secreted by your body, and its
secretion then signals the body to begin releasing testosterone.
HCG is typically employed by steroid-using
athletes to bring back some naturally produced testosterone into their
bodies. However, HCG is clinically used both to induce ovulation and
treat certain ovarian disorders in women. In men is utilized to
stimulate the testes in hypogonadal men (men who are not producing
testosterone). It has also shown promise in the treatment of
undescended testicles in young males.
The action of HCG in males is very similar to that of LH, because they
are chemically similar and since LH binds to receptors on human Leydig
cells, we see a similar mechanism of action with HCG. Once it binds and
begins to stimulate the receptors on the Leydig cells, it begins to
trigger the synthesis and secretion of testosterone. However, HCG will
only send an “artificial” signal to the testes through Leydig cell
stimulation. Thus, it is possible that HCG use can cause Leydig cell
desensitization. I don’t know of anyone who has actually experienced
this, nor who has even claimed that it’s happened to either them or a
friend, or whatever- anecdotal evidence here is scarce.
However, there are two schools of thought regarding HCG use,
and neither are very new. In fact, both have been around since the
earliest books on underground steroid use, and were spoken about more
than a decade ago by Dan Duchaine (Underground Steroid Handbook) and
also by W. Nathaniel Phillips (Anabolic Reference Guide volumes 1-6).
The latter author, by the way is actually Bill Phillips, the author of
Body for Life, and the former owner of both Muscle Media and EAS (ok,
so that was a bit off track…). Anyway, let’s talk about those two uses
When used on a cycle sparingly, HCG helps to maintain testicular size
and condition but it is speculated that the intermittent administration
of HCG will keep the testicles receptive to LH, when we eventually go
off a cycle. This may be due to HCG’s ability to maintain of a higher
level of Inter-Testicular-Testosterone (ITT), 
used during a cycle.
This could aid and quicken your recovery of the
hypothalamic-testicular-pituitary-axis. This is certainly possible.
When used after a cycle, it will still help in restoring your testicles
back to their original size, and provide stimulation for the Leydig
cells. Both methods have merit, and there’s no reason why you can’t use
HCG every third week at a one time dose (perhaps) 500iu or so, and then
use it at that same dose for a daily schedule at the outset of your
Post Cycle Therapy.
Interestingly, one study I looked at showed that by using Vitamin E
along with HCG, a greater blood plasma testosterone elevation. This
tells me that we should always be loading up on some Vitamin E the day
we’re shooting our HCG- 1,000iu of Vitamin E should be plenty. Another
welcome addition to use of HCG is Nolvadex. Using Nolvadex in
conjunction with HCG seems to make the chance of any inhibition of the
HPTA very unlikely.
As HCG is used to stimulate testosterone production, theoretically,
side effects could be the same as those associated with
Anabolic Steroids, although gynocomastia (development of breast tissue
in males) seems to be the most probable, though still uncommon.