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  Halotestin
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Halotestin

Chemical Name: Fluoxymesterone
Drug Class: Oral Anabolic Steroid

his is one of those steroids that’s really only going to be useful to a select group of people who have very specific goals, and even then will probably only be used within very specific parameters, and for limited time frames.

Halotestin (Fluoxymesterone) was made by modifying testosterone with three major groups- a 17alpha-methyl group, a 11beta-hydroxy group, and a 9-fluoro group. The last group is the one that the chemical name (Fluoxymesterone) comes from. The first modification makes it able to survive oral ingestion and the first pass through the liver without being destroyed. The second modification appears to inhibit conversion to estrogen (aromatization), and the final one…well…I have no idea except to say that it appears to make it highly anabolic and also a very good target for 5a-reduction (conversion to Dihydrotestosterone). Halotestin is typically rated as being 19x as anabolic as testosterone and 8.5x as androgenic. This is all well and good, in the rodents that those ratings were determined with, but in reality, those numbers are deceiving. Nobody I know has ever taken 10 mgs of Halotestin per day and said that it produced muscle gain equal to nearly 200 mgs per day of testosterone. That’s just silly, considering most people don’t really gain any muscle at all off of Halotestin- although their strength (and aggression) goes up quite a bit.

For the most part, people (and I’m saying people but really, I mean “men” because women don’t EVER use Halotestin) tend to use Halotestin for increasing strength and aggression in the gym or in competitions such as strongmen contests, powerlifting, or fights. Since Halo has no estrogenic activity the gains in strength that most people experience with it are very lean and not watery at all, although weight gain is virtually nil.

Halotestin is basically known for increasing aggression and strength, and for being liver toxic. Through personal experience, I can vouch for these first two effects, and studies have been done which certainly present strong evidence of Halo’s ability to increase liver enzyme activity (1). Thus, I typically recommend keeping doses of Halotestin at or under 40mgs/day. In addition, I can’t see a high degree of safety in being on it for longer than 6 weeks or so. As I said, it’s primary effects come through its ability to increase strength and aggression, so you can probably use it at a very reasonable dose of  10 mgs prior to a workout, competition, or fight. This would certainly be the most reasonable use of it, and probably the safest as well. …

Anecdotally, bodybuilders who are already of a very low bodyfat level have found that it has a bit of a volumizing effect on the pre-contest physique.  I would assume that this is due to Halo’s ability to increase the bodies hematocrit level, hemoglobin level, and additionally, red cell mass. (2)(3)(4)(5)

It may also be beneficial to fat loss, through regulation of fatty acid oxidation in the  and fast-twitch muscle mitochondria(5). All of this occurs through what are probably it’s ability to produce non-receptor mediated effects , since  it has a low affinity for binding to the Androgen Receptor Binding. (6)

On the black market, due to low demand, this is very infrequently found, so it’s a bit of a sellers market, with tabs going for up to a dollar per 10 mgs.

References:

1. Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods. 1995 Aug;33(4):187-95. Treatment with anabolic steroids increases the activity of the mitochondrial outer carnitine palmitoyltransferase in rat liver and fast-twitch muscle. Biochem Pharmacol. 1991 Mar 1;41(5):833-5.

2. Influence of fluoxymesterone on in vitro erythropoiesis affected by leukemic cells.Exp Hematol. 1984 Mar;12(3):171-6.

3. [Erythropoietin in serum and urine in healthy persons and patients with chronic renal disease upon hypoxic stimulation and hypoxic stimulation after pretreatment with fluoxymesterone (author's transl)]

4. Fluoxymesterone therapy in anemia of patients on maintenance hemodialysis: comparison between patients with kidneys and anephric patients.

5. Effects of synthetic androgen fluoxymesterone on triglyceride secretion rates in the rat.Proc Soc Exp Biol Med. 1975 Jun;149(2):452-4.

6. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.Endocrinology. 1984 Jun;114(6):2100-6.

 
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