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Omnadren 250 is a 250mg/ml combination of the 4 separate testosterones with the esters listed above.
Regardless of the attached ester, all testosterones will produce similar effects. Rapid increases in strength, size, and aggression will all result from the use of testosterone, regardless of ester. The ester delays the release of the compound into the body which has the result of helping determine injection frequency. Anecdotally, it’s often found that shorter esters produce less water retention, and this has been my experience as well.
Testosterone is both a highly anabolic and androgenic hormone, and this makes it a good drug to use for size and strength. Testosterone does this by promoting nitrogen retention in the muscle(1), and the more nitrogen the muscles holds the more protein the muscle subsequently stores and builds. Testosterone can also increase the levels of the IGF-1 in muscle tissue.(2)(3) IGF-1 is thought to be one of the primary growth factors responsible for anabolism. Of course, Testosterone converts to estrogen (via the aromatase enzyme in a process known as aromatization). But luckily, ven the aromatized part of testosterone that has converted estrogen may increase levels of IGF, as well as sensitivity to IGF and other growth factors. Testosterone’s anabolic actions are thought to be mostly due to genomic (transcription mediated) effects, which come mostly from binding to the androgen receptor (AR). After binding, gene transcription promotes AR dependant mechanisms for both muscle gain and fat loss (3). Testosterone also increases the concentrations of the AR in cells, which is critical for both muscle repair and growth in skeletal muscle.(5 ) Testosterone (and remember, that’s all Omnadren is) induces changes in shape and size of muscle fibers and also can change the appearance as well as the number of muscle fibers in your body.(2) Testosterone also reduces levels of catabolic hormones(5), providing a nice anti-catabolic effect.
Unfortunately, oily skin, acne, increased body/facial hair, alopecia (male pattern baldness) and an increase in aggressiveness can also occur with the use of Omnadren. Some of this is due to conversion to estrogen, while part of this is as a result of Testosterone the converting to Dihydrotestosterone (DHT). Testosterone is
converted to DHT via the 5-alpha reductase enzyme, and seems to be a reasonably good substrate for this enzyme, resulting in a decent amount of conversion. Having low levels of DHT can actually cause gynocomastia, it should be noted. (4)
Cycles which contain Omnadren 250 will typically be around 12-16 weeks, because users would want their testosterone levels to build up to very high levels, provided by the sustained release of the longer esters. Typically between 500-1000mgs are used, with the most common dose being an ampule every other day.
2. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7
3. Comparison of effects of the rise in serum testosterone by raloxifene and oral testosterone on serum insulin-like growth factor-1 and insulin-like growth factor binding protein-3. Hypothalamic sites of action for testosterone, dihydrotestosterone, and estrogen in the regulation of luteinizing hormone secretion in male sheep. Endocrinology. 1997 Sep;138(9):3686-94.
4. Case report: finasteride-induced gynecomastia in a 62-year-old man. Am J Med Sci. 1995 Jun;309(6):322-5.