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  Fareston-Toremifene Citrate
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Fareston

Chemical Name: Toremifene Citrate
Drug Class: Selective Estrogen Receptor Modulator

Contents



Fareston Profile


fareston 60mgsFareston is a Selective Estrogen Receptor Modulator (SERM), not unlike its more popular cousins Nolvadex and Clomid. Just as we see with Nolvadex, Fareston is used to treat breast cancer in post-menopausal women. It does this by exerting estrogen antagonistic effects in certain tissue, most notably, breast tissue. This is actually the same mechanism of action found in Nolvadex. This is why Nolvadex is often recommended to bodybuilders who are trying to avoid gynocomastia (growth of breast tissue in males). SERMs, in addition, have several other well known effects in men, which are not simply limited to preventing the abnormal growth of breast tissue.

At the hypothalamus and pituitary, estrogen acts in cooperation with the male bodyís negative feedback loop to send a signal to decrease the secretion of LH, and when LH secretion is lowered, so are natural testosterone levels. SERMs, like Fareston, possibly act as an estrogen antagonist in the hypothalamus and pituitary, in order to increase testosterone production. Thus, although it hasnít been studied to any great degree, itís highly likely that Fareston is capable of increasing testosterone in the same way that Nolvadex it, as itís androgenicity:estrogenicity ratio is 5x that of Nolvadex[1]. It may also be better than Nolvadex for reasons that are of particular interest to steroid using athletes and bodybuilders.

Fareston differs from Nolvadex in several ways, however- even though itís very similar to it in others. Firstly, the risk of certain side effects (although relatively rare with Nolvadex) is actually quite a bit lower with Fareston. However unlikely these risks are in the first place, the risk of stroke, pulmonary embolism, and cataract is probably lower with Fareston than with Nolvadex. This is going to be of interest to people who have issues with ďfloatersĒ in their vision, which is sometimes caused by Nolvadex and Clomid, as this product may represent significantly less occular toxicity. It also differs slightly from Nolvadex in its potent with regards to improving lipid (cholesterol) profiles. In terms of improving bone mineral density, Fareston is roughly equal to Nolvadex.[2]

Although anecdotal evidence on this compound is rare, bodybuilders who have already experimented with this stuff seem satisfied. In my estimation, it would seem to be a more potent and safer alternative to Nolvadex, for those who are worried about side effects. Iím also predicting that it may provide a greater increase in LH and therefore testosterone levels, in men when compared to Nolvadex (when an appropriate dose of each is utilized). This makes its use a strong possibility for PCT in the future, when studies on its ability to elevate testosterone is more fully studied and understood.

Fareston would also make a welcome addition to a cycle where Cholesterol issues may be a concern, or where something slightly stronger than Nolvadex may be required to prevent gyno.

Photos



Fareston schering
Fareston russian version

Science


Breast Cancer. 2012 Sep 12.
Phase III randomized trial of toremifene versus tamoxifen for Japanese postmenopausal patients with early breast cancer.
Kimura M, Tominaga T, Kimijima I, Takatsuka Y, Takashima S, Nomura Y, Kasumi F, Yamaguchi A, Masuda N, Noguchi S, Eshima N.

Department of Surgery, Gunma Cancer Center, Ota, Japan, [email protected]


Drug Insert


FARESTON drug insert

References


  1. ^ Breast Cancer Re Treat. 1990 Aug;16 Suppl:S3-7. Introduction to toremifene. Kangas L.
  2. ^ Breast 2006 Apr;15(2):142-57. Epub 2005 Nov 9.Toremifene: An evaluation of its safety profile. Harvey HA, Kimura , MHajba A

 
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