Indiscriminate use or abuse of Clenbuterol or Clen can lead to health problems, ranging from mild to severe, such as difficulty in breathing, gastrointestinal irritation, myocardial infarction, skin rash, urticaria, diaphoresis, nausea, tightness in the chest, vomiting, dizziness, depleted phosphate levels, dry mouth, insomnia, muscular shivering, cardiac hypertrophy, palpitation, potassium depletion, loss of concentration, frequent mood swings, and drowsiness.

In addition to that, Clenbuterol abuse is also associated with adverse reactions like increased blood pressure, muscle cramps, excessive sweating, heartburn, face flushes, tremors, and restlessness. Abuse of this medication for an indiscriminate duration can also cause infiltration of collagen materials into walls of the heart that causes the heart muscles to restrict, which may cause reduced cardiovascular function and risk of strokes and arrhythmia. Clenbuterol abuse may even cause muscle destruction in rare cases to cause a strain on the cardiovascular system, if the same is not supervised regularly.

It is worth noting that the use of Clen may outcome in liver poisoning when this weight-loss medication is stacked with medications, Accutane, oral 17-alpha-alkylated steroid drugs, or hepatotoxic (toxic to liver) elements. It is recommended that use of Clenbuterol should be stopped on an immediate basis and medical health advice should be sought at the first if the skin color goes yellow as this could be a clear sign of liver disease (inflammation of the liver).

Clen misuse may be a factor behind bone fragility and fractures as the medication adversely impacts the mechanical characteristics and micro-architecture of bone while Clenbuterol over-dose is associated with vertigo, headaches, anxiety, taurine depletion, hypophosphatemia, hypokalemia, stroke, and tachycardia. It is worth noting that Clen is not approved by the FDA for human use and is prohibited in many countries.