New test can detect new endurance drugsA team of researchers in Germany, led by Mario Thevis, Director of the Center for Preventive Doping Research at the German Sport University of Cologne, developed a new kind of test to detect a class of compounds known as benzothiazepines.

Benzothiazepines are known to treat variant angina, drug-induced, stable or naturally-occurring. Drugs such as Diltiazem contain this compound.

This compound is known to stop calcium leaking out of the muscles. Calcium is very important in obtaining optimum muscle contractions, end if it leaks out, then this would cause weakening and eventually, muscle fatigue.

Compounds in their early stage of development, especially when they have not undergone any human clinical trials, may be left undetected. In the past, tests are usually developed only after a drug is known to be in circulation.

This time, however, the researchers obtained molecular “fingerprints” of this compound to be used for future testing to trace JTV-519 and S-107 benzothiazepines. This is to help sports officials prepare for any future misuse of the drug. The test is ultra sensitive that it can even detect small concentrations of the compound found in urine to as low as 0.1 nanograms per milliliter.

According to Mario Thevis from Science Daily:

“We used the common approaches that are employed for detecting anabolic agents. Our work showed that we could identify the right compounds and that we have a sensitive test,” says Thevis.

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