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Tuesday 15, Nov 2011

  Steroids successfully treat Clopidogrel hypersensitivity

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A new study has confirmed that a single three-week course of prednisone can successfully treat Clopidogrel hypersensitivity without needing to interrupt treatment with the antiplatelet agent.

This study was conducted by a group led by Dr Asim Cheema (St Michael’s Hospital, Toronto, ON).

The study was published in the September 27, 2011 issue of the Journal of the American College of Cardiology.

Friday 16, Apr 2010

  Plavix allergic reaction are alleviated by antihistamines and steroids

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Plavix allergic reaction are alleviated by antihistamines and steroidsTreating cardiac patients who have suffered allergic reactions to clopidogrel (Plavix) is better with a combination of antihistamines and steroids as they can effectively alleviate allergic reaction symptoms, as per a recent study. Doctors from the Thomas Jefferson University Hospital remarked that patients can remain on the drug after the symptoms have been alleviated.

The study findings were presented at the American College of Cardiology’s Annual Scientific Session by Primary investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D.

Some members of the medical community that these findings offer implications to investigate ways for treating allergic reactions to other life-saving drugs.

Tuesday 02, Feb 2010

  Clopidogrel-related allergic reaction symptoms alleviated by steroids and antihistamines

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Clopidogrel-related allergic reaction symptoms alleviated by steroids and antihistaminesAccording to doctors from Thomas Jefferson University Hospital, clopidogrel-related allergic reaction symptoms can be alleviated when a combination therapy of steroids and antihistamines is followed.

It was revealed by Primary Investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D., cardiology fellow and lead author, who presented their findings at the American College of Cardiology’s Annual Scientific Session on March 30 2009 that reaction symptoms after use of clopidogrel, also known by the pharmaceutical name Plavix, can be treated with a combination of steroids and antihistamines.

John R. Cohn, M.D., chief of Adult Allergy at Thomas Jefferson University and Hospitals and a key contributor to the study noted that most patients tend to become tolerant to Plavix or desensitized to the drug after being administered with low doses of steroids and antihistamines while continuing the drug.

Wednesday 16, Dec 2009

  Study shows Plavix allergic reactions can be treated with steroids and antihistamines

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Study shows Plavix allergic reactions can be treated with steroids and antihistamines  According to doctors from Thomas Jefferson University Hospital, treatment with a combination of steroids and antihistamines can alleviate Plavix allergic reaction symptoms.

Plavix is a widely-prescribed drug also known by the name clopidogrel.

Primary Investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D., cardiology fellow and lead author, presented their findings at the American College of Cardiology’s Annual Scientific Session on March 30, 2009.

Previous anecdotal studies had suggested that some patients can be desensitized to Plavix but this is hailed as the first systematic study for demonstrating drug allergy could be easily and effectively managed without discontinuing the drug usage after a reaction has been experienced.

Thursday 26, Nov 2009

  Antihistamines and steroids alleviate clopidogrel allergic reaction symptoms

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Antihistamines and steroids alleviate clopidogrel allergic reaction symptomsTreating patients with a combination of steroids and antihistamines can alleviate allergic reaction symptoms to a considerable extent, as per a study of cardiac patients who have suffered allergic reactions to clopidogrel, also known as Plavix.

It was revealed by doctors from the Thomas Jefferson University Hospital that patients can remain on the drug after the symptoms have been alleviated. The study findings were presented at the American College of Cardiology’s Annual Scientific Session by Primary investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D.

It is considered by many that this study truly suggest that Plavix allergy can be effectively managed without discontinuing the drug after reactions have been observed and these findings can help members of the medical fraternity when it comes to treating allergic reactions to other life-saving drugs.

 

Monday 19, Oct 2009

  Study shows Plavix allergic reactions can be treated with steroids and antihistamines

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Study shows Plavix allergic reactions can be treated with steroids and antihistaminesA clinical study of cardiac patients suffering allergic reactions after using the widely-prescribed drug clopidogrel, also known by the pharmaceutical name Plavix, has found that allergic symptoms can be alleviated with a combination of steroids and antihistamines. This kind of a treatment can prove to be an effective option for allowing the patients to remain on the drug, as per doctors from the Thomas Jefferson University Hospital.

Plavix is considered to be one of the most widely prescribed drugs on a worldwide basis and it is estimated that approximately six percent of Plavix users display some signs of allergic reaction(s). This first-of-its-kind systematic study clearly demonstrates drug allergy can be effectively managed without discontinuing the usage after experiencing the allergic symptoms.

Sunday 06, Sep 2009

  Steroids and antihistamines alleviate symptoms relating to clopidogrel allergic reaction

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Steroids and antihistamines alleviate symptoms relating to clopidogrel allergic reactionAccording to a study of cardiac patients who have suffered allergic reactions to clopidogrel, also known as Plavix, treatment with a combination of antihistamines and steroids can alleviate allergic reaction symptoms. Once the symptoms are alleviated, patients remain on the drug, as per doctors from the Thomas Jefferson University Hospital.

The findings of this study were presented at the American College of Cardiology’s Annual Scientific Session by Primary investigator Michael P. Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital and Kimberly L. Campbell, M.D.

This study is hailed as the first one that demonstrates allergy to Plavix can be managed without discontinuing the drug after experiencing a reaction. It was remarked by members of the medical fraternity that the findings can go a long way in investigating ways for treating allergic reactions to other life-saving drugs.

Wednesday 22, Jul 2009

  Steroids as treatment for allergic reactions to Plavix

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Steroids as treatment for allergic reactions to PlavixPlavix (Clopidogrel), a widely prescribed drug for cardiac patients, is estimated to cause allergic reactions in about six percent of those taking the drug. It is an important medication especially for those who underwent angioplasty with aortic stent. Aortic stents are used to prevent further injury and bleeding within the vessel and taking the drug,Plavix, helps prevent clotting of the stent (stent thrombosis). Maintenance of the drug would usually last for a year following stent procedure. Discontinued use might pose as a risk for a fatal heart attack.

One major problem encountered, however, is the allergic symptom that might surface following drug intake. Previous treatment is usually done by giving the patient an alternative drug but it can also have its side effects. A team of cardiologist at the Thomas Jefferson University Hospital, decided to tackle a different approach to this problem. Instead of looking for althernative drugs, they decided to concentrate on decreasing or suppressing allergic symptoms by administering low doses of steroids and antihistamines while continuing Plavix medication.

The result is a surprising “desensitization” to the drug, enabling them to continue with the treatment. After this, steroids and antihistamines were discontinued. This is the first reported systematic study to demonstrate that allergic reactions to the drug could be managed even without its discontinued use.

Wednesday 20, May 2009

  Plavix allergic reactions get treated with Steroids and Antihistamines

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Plavix allergic reactions get treated with Steroids and AntihistaminesA recently concluded clinical study by doctors from the Thomas Jefferson University Hospital suggested that allergic reactions to the widely-prescribed drug Clopidogrel, also known as Plavix, can be treated with a combination of antihistamines and steroids.

Plavix is considered to be one of the most prescribed drugs worldwide. Since 2007, it has been the fourth most-sold drug in terms of sales volume in the United States. It is estimated that around 6 percent of its users show signs of allergic reactions.

This study followed 24 patients who signs of Plavix allergies after undergoing the procedures of coronary stent. As much as 87 percent patients were able to stay on Plavix after being treated with antihistamines and steroids.

It means that patients can continue to remain on Plavix after being treated with steroids and antihistamines. It also means that patients who have received stent (a slender tube that is inserted inside a tubular body part as a vessel of blood to offer support during and after surgical anastomosis) can be protected from stent clotting (stent thrombosis) with a combination of antihistamines & steroids.

This is the first systematic study demonstrating management of allergy caused by Plavix without stopping the drug after reactions are noticed by a patient or physician.