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Sunday 19, Sep 2010

  Transplanted kidney can be preserved with experimental drugs

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Transplanted kidney can be preserved with experimental drugsAccording to a finding by an international team of transplant physicians, Belatacept (LEA29Y), the investigational drug, could prove effective as Cyclosporine (a drug) used for preserving kidney function besides preventing the immune system from rejecting transplanted organs.

Christian P. Larsen, MD, PhD, director of the Emory Transplant Center and professor of surgery at Emory University School of Medicine, and Flavio Vincenti, MD, of the University of California, San Francisco were co-lead authors of the article. The findings from a Phase II clinical trial of belatacept were published in the August 25 issue of the New England Journal of Medicine.

The team revealed that patients undergoing long-term anti-rejection therapy with immunosuppressant drugs and administered with belatacept can avoid toxic side effects that have adverse effects on kidney function, blood pressure, and cholesterol levels.

Thursday 08, Jul 2010

  Experimental drugs effective for preserving transplanted kidneys

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Experimental drugs effective for preserving transplanted kidneysKidney function can be preserved by Belatacept (LEA29Y), the investigational drug, as effectively as the drug commonly used to prevent the immune system from rejecting transplanted organs, Cyclosporine. This finding was disclosed by an international team of transplant physicians.

It was also disclosed by the team that belatacept can help patients undergoing long-term anti-rejection therapy with immunosuppressant drugs avoid toxic side effects that adversely affect kidney function, blood pressure, and cholesterol levels.

The findings from a Phase II clinical trial of belatacept were published in the August 25 issue of the New England Journal of Medicine. Christian P. Larsen, MD, PhD, director of the Emory Transplant Center and professor of surgery at Emory University School of Medicine, and Flavio Vincenti, MD, of the University of California, San Francisco were co-lead authors of the article.

Sunday 30, May 2010

  Tumor recurrence can be caused by high immunosuppressant levels

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Tumor recurrence can be caused by high immunosuppressant levelsHigh levels of the immunosuppressant cyclosporine favor tumor recurrence as per a study on the incidence of liver cancer. The study was also able to identify blood levels of the drug that must not exceed besides identifying that low cyclosporine levels have no effect on the rejection rates.

The study results appeared in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

The journal was published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

Wednesday 12, May 2010

  Transplanted kidneys are preserved by experimental immunosuppressant drugs

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Transplanted kidneys are preserved by experimental immunosuppressant drugsBelatacept (LEA29Y), the investigational drug, is effective in preserving kidney function as much as cyclosporine, the drug most commonly used for preventing the immune system from rejecting transplanted organs as per an international team of transplant physicians.

It was also disclosed that belatacept is able to avoid many of the toxic side effects that tend to adversely affect blood pressure, kidney function, and cholesterol levels of patients undergoing long-term anti-rejection therapy with immunosuppressant drugs.

The findings from a Phase II clinical trial of belatacept were published in the August 25 issue of the New England Journal of Medicine. Christian P. Larsen, MD, PhD, director of the Emory Transplant Center and professor of surgery at Emory University School of Medicine, and Flavio Vincenti, MD, of the University of California, San Francisco, are co-lead authors of the article.

Thursday 25, Mar 2010

  Tumor recurrence may happen due to high immunosuppressant levels

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Tumor recurrence may happen due to high immunosuppressant levelsA study has found that high levels of immunosuppressant, cyclosporine, can result in incidence of liver tumor. The study also identified that such high levels favor tumor recurrence besides identifying blood levels of the drug that should not be exceeded.

The study results appeared in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).

The study was published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

Sunday 10, Jan 2010

  Transplanted kidneys preserved by experimental immunosuppressant drug

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Transplanted kidneys preserved by experimental immunosuppressant drugAn international team of transplant physicians has come to the conclusion that investigational drug belatacept (LEA29Y) is helpful in preserving transplanted kidney function as effectively as cyclosporine, the drug commonly used for preventing the immune system from rejecting transplanted organs.

It was also concluded that belatacept prevents many toxic side effects that can adversely affect blood pressure, kidney function, and cholesterol levels in patients undergoing anti-rejection therapy with immunosuppressant drugs in the long term.

The findings were published in an issue of the New England Journal of Medicine. Christian P. Larsen, MD, PhD, director of the Emory Transplant Center and professor of surgery at Emory University School of Medicine, and Flavio Vincenti, MD, of the University of California, San Francisco, are co-lead authors of the article.