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Wednesday 30, Dec 2009

  Minimizing eosinophilic airway inflammation in severe asthma

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Minimizing eosinophilic airway inflammation in severe asthmaA high dosage of extra intramuscular corticosteroids can result in almost-complete disappearance of eosinophilic cells leading to reduced use of “rescue” medications apart from facilitating improvements in lung function tests of patients. This finding was revealed by investigators during a study of patients with severe asthma having eosinophils in their sputum despite extensive antiasthma medication.

Eosinophils are a type of white blood cell that constitute around 1-3 percent of the total white cell count in the body. When infectious cells or foreign substances enter the body, lymphocytes and neutrophils attract eosinophils that release toxic substances to destroy abnormal cells.

The authors note that injected corticosteroids can reach the region of bone marrow besides minimizing eosinophils being produced by processes involving inflamed tissue.

Tuesday 23, Jun 2009

  Steroid Nasal Spray Effective against Hay Fever

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Steroid Nasal Spray Effective against Hay FeverResearchers from the University of Chicago have found that fluticasone propionate (Flonase), a corticosteroid nasal spray, is more effective than a combination of popular anti-allergy drugs loratidine (Claritin) and montelukast (Singulair) when it comes to controlling seasonal allergies.

The findings of this study were presented at the 58th annual meeting of the American Academy of Allergy, Asthma and Immunology.

Robert Naclerio, M.D., professor of surgery at the University of Chicago and director of the study, remarked that the measures of inflammation were considerably better for Hay fever patients who were taking fluticasone propionate.

During the study, it was found that the use of nasal spray results in fewer eosinophils in patients’ nasal passages and patients using steroid nasal sprays displayed minimal side-effects and had lower levels of eosinophil cationic protein, an inflammation sign.

Naclerio remarked that fluticasone may be a better first choice for the treatment of seasonal allergic rhinitis because of its benefits and low cost.