Teriparatide, the anabolic agent, has received a boost in status as a preferentially effective treatment for glucocorticoid-induced osteoporosis in the form of a second, confirmatory, randomized double-blind trial.

The trial demonstrated that the drug achieves substantially greater increases in bone mineral density compared to a bisphosphonate.

These positive study findings are bolstered by a biologically plausible mechanism of benefit, according to the observations of Dr. Kenneth G. Saag at the annual meeting of the American Society for Bone and Mineral Research.

Tags: bone-mineral density, osteoporosis, steroids, teriparatide

Posted in Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

Chemotherapy for lymphoma should be recognized as a risk factor for the development of osteoporosis, according to Dr. Bhaskar Dasgupta in a poster session at the annual meeting of the British Society for Rheumatology.

Dr. Dasgupta, director of rheumatology, Southend Hospital NHS Trust, Westcliff on Sea, England, said patients with lymphoma have greatly improved survival rates because of advances in treatment, but their quality of life may be compromised by long-term complications of chemotherapy.

Osteoporosis is a complication that can result from treatment with alkylating agents and the steroids that are usually given with chemotherapy.

Tags: chemotherapy, corticosteroid, osteoporosis, steroid dose, steroids

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Children afflicted with nephrotic syndrome and who have been administered with steroid drugs do not have to face the risk of bone loss, which is one of the common side effects of treatment based on steroids for adults.

Childhood nephrotic syndrome, which is believed to affect 3 out of 100,000 children, leads to weakening of ability of the body to remove water and salt from the blood and cause swelling in the belly, legs, and around the eyes.

It was remarked by Dr. Leonard that these report findings could be helpful in assuring parents and physicians about steroid-based treatment in order to offer help to children with nephrotic syndrome as steroids do not enhance their risk of osteoporosis.

Tags: bone loss, Nephrotic syndrome, osteoporosis, steroid, steroids

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Low level of testosterone is a cause of concern for approximately 15 million men in the United States alone. The worrying fact is that a big majority of this population remains undiagnosed and untreated.

Dr. Ronald Tamler, the director of the Men’s Health Program at Mount Sinai Medical Center, said that testosterone has a significant influence on sexual desire and testosterone is effective against osteoporosis and helps in preserving lean body mass.

Tamler remarked that men with low testosterone levels are prone to higher risk of diabetes, heart disease, and early mortality.

Tags: erectile dysfunction, lean body mass, osteoporosis, testosterone

Posted in Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

Children afflicted with severe asthma should be taking an over-the-counter calcium supplement and a multi-vitamin every day for preventing loss of bone associated with osteoporosis, as per an article published in the Journal of Allergy and Clinical Immunology.

Joseph Spahn, M.D., an author of the article and a pediatric asthma specialist at National Jewish Medical and Research Center, said that a child does not have to be dependent on steroids to get osteoporosis.

It is worth noting here that inhaled corticosteroids reduce and prevent swelling of the airways and oral (pills or syrup) corticosteroids relax tight muscles around the airways.

Tags: calcium supplement, corticosteroids, Oral Steroids, osteoporosis, steroid side effects, steroids, supplement

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A recent study has determined that Teriparatide, a synthetic form of the human parathyroid hormone, could be used to effectively treat steroid-induced osteoporosis.

It was found by the involved researchers that osteoporosis patients when treated with teriparatide for a period of 36 months had a greater increase in BMD (bone mineral density) and fewer new vertebral fractures than those treated with alendronate.

The findings of this study were published in an issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR).

Tags: alendronate, BMD, osteoporosis, steroids, teriparatide

Posted in Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

Terming as a serious international public health concern, results from the Global Longitudinal Study of Osteoporosis in Women (GLOW) have shown that there is a failure in perceiving the implications of important risk factors among women even though the fairer sex is at an increased risk for osteoporosis-associated fractures. This latest study from GLOW, which is based at the Center for Outcomes Research at the University of Massachusetts Medical School, was published in the journal Osteoporosis International and evaluated more than 60,000 postmenopausal women in 10 countries.

Lead author of the paper, Ethel Siris, MD, GLOW investigator and Director of the Toni Stabile Osteoporosis Center of the Columbia University Medical Center, New York-Presbyterian Hospital, said most women are not making the association between their risk factors and the serious consequences of fractures.

Tags: osteoporosis, Prednisone, steroids

Posted in Steroid Cycles, steroid nation, Steroids and Anabolic Steroids

A serious international public health concern was recently raised by researchers after results from the Global Longitudinal Study of Osteoporosis in Women (GLOW) showed that women are at an increased risk for osteoporosis-associated fractures.

It was also suggested by the study that there is a complete failure among women to perceive the implications of having important risk factors.

Tags: cortisone, osteoporosis, Prednisone, public health, Rheumatoid arthritis, steroids

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The injectable form of Teriparatide, Forteo, is superior to oral Alendronate, Fosamax, in a head-to-head comparison when it comes to improving bone mineral density (BMD) by as much as twice.

Teriparatide promotes greater increases in bone-mineral density at the spine and hip, as per Kenneth Saag, M.D., of the University of Alabama at Birmingham and his colleagues.

Philip N. Sambrook, M.D., of the University of Sydney, said that Saag’s findings suggest that teriparatide is a superior drug for treating steroid-induced Osteoporosis.

Tags: bone-mineral density, oral alendronate, osteoporosis, teriparatide

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The introduction of HAART (Highly Active Antiretroviral Therapy) may have improved the survival and quality of life for people infected with the human immunodeficiency virus (HIV-1) but this improved prognosis has also resulted in long term negative disorders, namely osteoporosis.

Osteoporosis is a multifactorial disease characterized by reductions in bone mass leading to an increased propensity to bone fractures.

A study published in the Spanish review Enfermedades Infecciosas y Microbiología Clínica [Infectious Diseases and Clinical Microbiology] revealed that the prevalence of osteoporosis in HIV-1 infected patients.

The authors said that clinical trial results are awaited with a hope to bring new evidence about the possible effectiveness of anti-osteoporotic treatment in these patients.

Tags: corticosteroid, osteoporosis, steroids

Posted in Steroid Cycles, steroid nation, Steroids and Anabolic Steroids