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Friday 07, Nov 2014

  Improved Abilities Discovered For Detecting HCG Doping In Sport

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Improved Abilities Discovered For Detecting HCG Doping In Sport

A new peer-reviewed research conducted by Getachew A. Woldemariam and Dr. Anthony W. Butch may place a vital role in the day to come for detecting athletes who are taking human chorionic gonadotropin (hCG) to enhance athletic performance.

Woldemariam and Butch through their research developed ways to specifically measure several forms of hCG in urine. In females, urinary human chorionic gonadotropin is a marker of pregnancy. The new test, by specifically measuring the various forms of hCG in male urine, can better detect athletes who are taking hCG.

Butch remarked this immunoextraction and tandem mass spectrometry method for measuring the major isoforms of chorionic gonadotropin in urine is a significant improvement over currently available immunoassays. Dr. Butch further added that the method has superior analytical specificity and will greatly enhance the ability to detect male athletes who dope with various forms of chorionic gonadotropin.

Dr. Larry Bowers, PCC Scientific Advisory Board Chair and USADA Chief Science Officer, commented that the measurement of male urinary hCG in anti-doping has been an area of concern for many years. Dr. Bowers added this important research has not only developed a sensitive and specific LC-MS/MS assay which will help us to detect the various forms of hCG and those who use it to cheat their competitors, but Woldemariam and Butch have greatly added to our knowledge about hCG excretion after administration. It was further remarked by Bowers that with the specificity of the LC-MS/MS method, it should be possible to provide additional information about the concentration of intact hCG in male urine samples who have not doped and therefore increase the sensitivity of the test.

The World Anti-Doping Agency (WADA), based on the study results, is in the process of developing new guidelines for WADA-accredited labs for conducting tests.

Human chorionic gonadotropin has the ability to stimulate production of Testosterone in the body and is presently classified as a banned substance on the World Anti-Doping Agency list. It is commonly used by athletes and bodybuilders with synthetic anabolic steroids. Medical practitioners recommend this hormone to young boys when their testicles have not dropped down into the scrotum (due to a pituitary gland disorder) in a normal way. Use of HCG is commonly made by athletes and bodybuilders during a steroid cycle to maintain testosterone production and testicle size. Bioavailability of the HCG injection is better with intravenous administration than with subcutaneous administration.

In the last few years, HCG has been marketed for weight loss and it is believed that it can improve mood, assist in fat burning, and reduce hunger. Many elite bodybuilders have successfully used HCG to get rid of stubborn fat and fat accumulated in the abdomen and the thighs without compromising on muscle mass. HCG abuse can result in health complications such as breast enlargement in women, sudden development of facial or pubic hair in adolescents, indigestion, difficulty in breathing, rapid weight or height gain, bloating, and nausea.

The research, which was published in the August issue of Clinical Chemistry, was funded by the Partnership for Clean Competition (PCC).

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Friday 10, Aug 2012

  Nate Marquardt Wins Strikeforce Gold

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Nate Marquardt Wins Strikeforce Gold – Cliff Notes

@Nate Marquardt, the former UFC contender, has won the vacant Strikeforce welterweight championship with a knockout of Tyron Woodley.

 Nate Marquardt – Post Tyron Woodley Interview – Strikeforce MMA

A few years ago, the MMA fighter admitted in an interview that he was suffering from low testosterone levels and his doctor recommended testosterone replacement therapy (TRT). Before his fight against Dan Miller in New Jersey, he requested a therapeutic-use exemption (TUE) but the New Jersey State Athletic Control Board indicated that request of his doctor was incomplete and the TRT treatment was not in accordance with the standards of USADA. The Board said they would authorize the testosterone treatment as long as Marquardt agrees to go off treatment for eight weeks and take three blood tests after the fight.

However, the personal doctor of the fighter suggested aggressive treatment and recommended injecting the testosterone straight rather than allowing Marquardt to take oral medications that promote the pituitary gland to spur testosterone production in the testicles. The testosterone injections pushed the fighter’s levels out of the range accepted by the Pennsylvania State Athletic Commission (PSAC) and UFC President fired Marquardt through Twitter.

White said Nate Marquardt would never fight in the UFC again after he failed to clear his medicals for his main event fight against Rick Story at a UFC event in Pittsburgh. Marquardt then went public and disclosed that his medicals failed because of elevated levels of testosterone due to a testosterone replacement therapy, or TRT. The UFC President added that the MMA fighter tested positive for anabolic steroids in 2006, was on suspension for New Jersey, then failed to clear his medicals at Pennsylvania, and could not get a fourth chance. White added that there is a difference between testosterone replacement therapy and getting to levels where it is performance enhancing.

Born on April 20, 1979, Marquardt is an American mixed martial artist running the High Altitude Martial Arts Academy in Aurora, Colorado. Marquardt (31-10-2) has compiled 10 wins since joining the UFC in 2005 and has fought for the middleweight title in 2007 against Anderson Silva, which he lost via first-round TKO. Marquardt came close twice in 2010 to compete for the title again but fell short after decision losses to Chael Sonnen and Yushin Okami. On July 3, 2010 he was expected to face Alessio Sakara but the flight was called off after Sakara pulled out due to the death of his father. On March 19, 2011 at UFC 128, he won a fight against Dan Miller via unanimous decision after Yoshihiro Akiyama pulled out of the bout. The MMA fighter signed with top U.K. fight promotion BAMMA, the British Association of Mixed Martial Arts after his suspension was lifted by the Pennsylvania State Athletic Commission.

Recently, Dana White made an announcement that the fighter has signed with Strikeforce and his debut was Strikeforce: Rockhold vs. Kennedy against Tyron Woodley in a bout for the vacant Strikeforce Welterweight Championship where he knocked out Woodley to become the Strikeforce Welterweight champion. The former UFC contender Nate Marquardt controlled the stand-up for the first two rounds and held off takedown attempts of Woodley to emerge victorious.


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